Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sigma-1 receptor knockout"'
Publikováno v:
Pharmacological Research, Vol 191, Iss , Pp 106771- (2023)
Over the last decade, sigma-1 receptor (Sig1R) has been recognized as a valid target for the treatment of seizure disorders and seizure-related comorbidities. Clinical trials with Sig1R ligands are underway testing therapies for the treatment of drug
Externí odkaz:
https://doaj.org/article/fcee1aaa25db4baa8c677bd6ad2d9fd1
Publikováno v:
Pharmacological Research. 191:106771
Over the last decade, sigma-1 receptor (Sig1R) has been recognized as a valid target for the treatment of seizure disorders and seizure-related comorbidities. Clinical trials with Sig1R ligands are underway testing therapies for the treatment of drug
Autor:
Baiba Zvejniece, Karlis Vilks, Gundega Stelfa, Lasma Lauberte, Einars Kupats, Liga Zvejniece, Edijs Vavers, Baiba Svalbe, Rudolfs Mezapuke, Maija Dambrova
Publikováno v:
Neurobiology of Disease, Vol 150, Iss, Pp 105244-(2021)
There is a growing body of evidence demonstrating the significant involvement of the sigma-1 chaperone protein in the modulation of seizures. Several sigma-1 receptor (Sig1R) ligands have been demonstrated to regulate the seizure threshold in acute a
Autor:
Shawn Scatliffe, Christopher R. McCurdy, Stephanie Chen, Bin Shen, Christopher Lau, Zheng Miao, Ahmad Salehi, Sanjiv S. Gambhir, Kota Kaneshige, Adam J. Shuhendler, Mikael Palner, Lauren Andrews, Frederick T. Chin, Stanley M. Parsons, Michelle L. James, Natasha Arksey
Publikováno v:
EJNMMI research, vol 5, iss 1
EJNMMI Research
EJNMMI Research
Background This study aims to further evaluate the specificity and selectivity of [18F]FTC-146 and obtain additional data to support its clinical translation. Methods The binding of [19F]FTC-146 to vesicular acetylcholine transporter (VAChT) was eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0279df81ac86a4dd59af3e89ad9560
https://escholarship.org/uc/item/8j9269dt
https://escholarship.org/uc/item/8j9269dt
Akademický článek
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Akademický článek
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Autor:
José M. Baeyens, Francisco R. Nieto, Cruz Miguel Cendán, Eduardo Fernández-Segura, F.J. Cañizares, María Jesús Álvarez Cubero, José Miguel Vela
Publikováno v:
Molecular Pain
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Background Paclitaxel, a widely-used antineoplastic drug, produces a painful peripheral neuropathy that in rodents is associated with peripheral-nerve mitochondrial alterations. The sigma-1 receptor (σ1R) is a ligand-regulated molecular chaperone in