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of 195
pro vyhledávání: '"Sigma ligands"'
Akademický článek
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Autor:
Evangelia Sereti, Chrisiida Tsimplouli, Elisavet Kalaitsidou, Nikos Sakellaridis, Konstantinos Dimas
Publikováno v:
Biomedicines, Vol 9, Iss 1, p 38 (2021)
Sigma (σ) receptors have attracted great interest since they are implicated in various cellular functions and biological processes and diseases, including various types of cancer. The receptor family consists of two subtypes: sigma-1 (σ1) and sigma
Externí odkaz:
https://doaj.org/article/e06f8b03b41e46b1a205a01574e0aa6b
Publikováno v:
Expert Opinion on Therapeutic Targets. 24:1009-1028
The sigma receptors are found abundantly in the central nervous system and are targets for the treatment of various diseases, including Alzheimer's (AD), Parkinson's (PD), Huntington's disease (HD), depression, amyotrophic lateral sclerosis (ALS), an
Autor:
Giuseppe Gasparre, Marcello Leopoldo, Carmen Abate, Savina Ferorelli, Francesco Berardi, Giuseppe Cassano, Roberta Marottoli, Mauro Niso, Philip D. Mosier
Publikováno v:
Future Medicinal Chemistry. 11:2547-2562
Aim: The σ1 receptor is a druggable target involved in many physiological processes and diseases. To clarify its physiology and derive therapeutic benefit, nine analogs based on the σ1 antagonist PB212 were synthesized replacing the 4-methylpiperid
Autor:
Elisavet Kalaitsidou, Konstantinos Dimas, Nikos Sakellaridis, Evangelia Sereti, Chrisiida Tsimplouli
Publikováno v:
Biomedicines, Vol 9, Iss 38, p 38 (2021)
Biomedicines
Volume 9
Issue 1
Biomedicines
Volume 9
Issue 1
Sigma (&sigma
) receptors have attracted great interest since they are implicated in various cellular functions and biological processes and diseases, including various types of cancer. The receptor family consists of two subtypes: sigma-1 (&sig
) receptors have attracted great interest since they are implicated in various cellular functions and biological processes and diseases, including various types of cancer. The receptor family consists of two subtypes: sigma-1 (&sig
Publikováno v:
Chemmedchem
With the aim to develop new σ2 receptor ligands, spirocyclic piperidines or cyclohexanamines with 2‐benzopyran and 2‐benzofuran scaffolds were connected to the 6,7‐dimethoxy‐1,2,3,4‐tetrahydroisoquinoline moiety by variable linkers. In add
Autor:
Bikash R. Pattnaik, Lian-Wang Guo, Jun Li, Huan Yang, Yingmei Fu, Christopher R. McCurdy, Xinying Liu, Timur A. Mavlyutov
Publikováno v:
Oncotarget
// Xinying Liu 1, * , Yingmei Fu 2, 3, * , Huan Yang 2 , Timur Mavlyutov 2, 4 , Jun Li 2, 5 , Christopher R. McCurdy 6 , Lian-Wang Guo 2, 7, 8 and Bikash R. Pattnaik 7, 9 1 Departments of Pediatrics, University of Wisconsin School of Medicine and Pub
Autor:
Jens Köhler, Martin Giera, Franz Bracher, Bernhard Wünsch, Kirstin Lehmkuhl, Dirk Schepmann, Inga Knappmann
Publikováno v:
Bioorganic and Medicinal Chemistry, 25(13), 3384-3395
In order to obtain enantiomerically pure σ1 receptor ligands with a 2-benzopyran scaffold an Oxa-Pictet-Spengler reaction with the enantiomerically pure 2-phenylethanol derivatives (R)-4 and (S)-4 was envisaged. The kinetic resolution of racemic alc
Akademický článek
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Akademický článek
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