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Polysialic acid promotes remyelination in cerebellar slice cultures by Siglec-E-dependent modulation of microglia polarization

Autor: Lara-Jasmin Schröder, Hauke Thiesler, Lina Gretenkort, Thiemo Malte Möllenkamp, Martin Stangel, Viktoria Gudi, Herbert Hildebrandt

Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system. Spontaneous restoration of myelin after demyelination occurs, but its efficiency declines during disease progression. Efficient myelin repair requires fine-tun

Externí odkaz: https://doaj.org/article/62d093035d4d4638a8e6f54ae314798b

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Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation

Autor: Yaw-Wen Hsu, Fu-Fei Hsu, Ming-Tsai Chiang, Dong-Lin Tsai, Fu-An Li, Takashi Angata, Paul R. Crocker, Lee-Young Chau

Publikováno v: Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-15 (2021)

Abstract Background The accumulation of lipid-laden macrophages, foam cells, within sub-endothelial intima is a key feature of early atherosclerosis. Siglec-E, a mouse orthologue of human Siglec-9, is a sialic acid binding lectin predominantly expres

Externí odkaz: https://doaj.org/article/2f0f3b273fa448dba3cf937927f8cb07

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Akademický článek

Interplay Between Sialic Acids, Siglec-E, and Neu1 Regulates MyD88- and TRIF-Dependent Pathways for TLR4-Activation During Leishmania donovani Infection

Autor: Joyshree Karmakar, Chitra Mandal

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

TLR4 activates two distinct signaling pathways involving adaptors MyD88 and TRIF to produce proinflammatory cytokines and type-I interferon respectively. How Leishmania donovani suppresses these pathways is not well studied. We earlier reported, TLR4

Externí odkaz: https://doaj.org/article/22d903a42cdf40ff8b887230b93f835c

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Sialic Acid-Siglec-E Interactions During Pseudomonas aeruginosa Infection of Macrophages Interferes With Phagosome Maturation by Altering Intracellular Calcium Concentrations

Autor: Kaustuv Mukherjee, Biswajit Khatua, Chitra Mandal

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Pseudomonas aeruginosa (PA) is commonly associated with nosocomial and chronic infections of lungs. We have earlier demonstrated that an acidic sugar, sialic acid, is present in PA which is recognized and bound by sialic acid binding immunoglobulin t

Externí odkaz: https://doaj.org/article/0fb963320f8247398c92597cca25d8a1

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Akademický článek

Expression of Siglec-E Alters the Proteome of Lipopolysaccharide (LPS)-Activated Macrophages but Does Not Affect LPS-Driven Cytokine Production or Toll-Like Receptor 4 Endocytosis

Autor: Manjula Nagala, Emma McKenzie, Hannah Richards, Ritu Sharma, Sarah Thomson, Pietro Mastroeni, Paul R. Crocker

Publikováno v: Frontiers in Immunology, Vol 8 (2018)

Siglec-E is a murine CD33-related siglec that functions as an inhibitory receptor and is expressed mainly on neutrophils and macrophage populations. Recent studies have suggested that siglec-E is an important negative regulator of lipopolysaccharide

Externí odkaz: https://doaj.org/article/c77e1c4fe3b74d7c8a4181455dee7adf

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Sialic acid-binding immunoglobulin-like lectin 9 as a potential therapeutic target for chronic obstructive pulmonary disease

Autor: Zi Chen, Shuang-Lan Xu, Lin-Yang Ge, Jin Zhu, Tao Zheng, Zhou Zhu, Linfu Zhou, Pei-Fang Wei

Publikováno v: Chinese Medical Journal
Chinese Medical Journal, Vol 134, Iss 7, Pp 757-764 (2021)

Chronic obstructive pulmonary disease (COPD) has become the third-leading cause of death worldwide, which is a severe economic burden to the healthcare system. Chronic bronchitis is the most common condition that contributes to COPD, both locally and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fffb26755e1ff74655d17f78d86e0a8
http://europepmc.org/articles/PMC8104259

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