Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Siglec-8"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is a sialoside-binding receptor expressed by eosinophils and mast cells that exhibits priming status- and cell type-dependent inhibitory activity. On eosinophils that have been primed with IL-
Externí odkaz:
https://doaj.org/article/5786e146a72f4317828ee7f778030fb2
Autor:
Jada Suber, Yugen Zhang, Ping Ye, Rishu Guo, A. Wesley Burks, Michael D. Kulis, Scott A. Smith, Onyinye I. Iweala
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Background10% of US residents have food allergies, including 2% with peanut allergy. Mast cell mediators released during the allergy effector phase drive allergic reactions. Therefore, targeting sensitized mast cells may prevent food allergy symptoms
Externí odkaz:
https://doaj.org/article/235c9cf6bf554d9cb4467df4f525ce3d
Publikováno v:
World Allergy Organization Journal, Vol 15, Iss 8, Pp 100676- (2022)
Eosinophilic disorders include a wide array of conditions in which eosinophils play a primary pathophysiologic role. While historically treated with corticosteroids and immunosuppressants, knowledge of eosinophil biology has led to the development of
Externí odkaz:
https://doaj.org/article/068b21f1aa104bcc92bb4558f2c99e9f
Autor:
Nader Morshed, William T Ralvenius, Alexi Nott, L Ashley Watson, Felicia H Rodriguez, Leyla A Akay, Brian A Joughin, Ping‐Chieh Pao, Jay Penney, Lauren LaRocque, Diego Mastroeni, Li‐Huei Tsai, Forest M White
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 12, Pp 1-27 (2020)
Abstract Alzheimer’s disease (AD) is characterized by the appearance of amyloid‐β plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Using mass spectrometry, we have quantified the phosphoproteome of the CK
Externí odkaz:
https://doaj.org/article/7b9677d83e734c9bb4414abb7d975e62
Autor:
Wouter Korver, Alan Wong, Simon Gebremeskel, Gian Luca Negri, Julia Schanin, Katherine Chang, John Leung, Zachary Benet, Thuy Luu, Emily C. Brock, Kenneth Luehrsen, Alan Xu, Bradford A. Youngblood
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunomodulation of mast cell (MC) activity is warranted in allergic and inflammatory diseases where MCs have a central role in pathogenesis. Targeting Siglec-8, an inhibitory receptor on MCs and eosinophils, has shown promising activity in preclinic
Externí odkaz:
https://doaj.org/article/fc996b1aedce4815b6a0eb6f4573d07f
Autor:
Simon Gebremeskel, Julia Schanin, Krysta M. Coyle, Melina Butuci, Thuy Luu, Emily C. Brock, Alan Xu, Alan Wong, John Leung, Wouter Korver, Ryan D. Morin, Robert P. Schleimer, Bruce S. Bochner, Bradford A. Youngblood
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents a global health crisis. Immune cell activation via pattern recognition receptors has been implicated as a driver of the hyperinflammatory response seen in COVID-19. However
Externí odkaz:
https://doaj.org/article/6c36a84cb2e642e38ca9f2806e606704
Akademický článek
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Autor:
Anna Trebo, Nina Ditsch, Tom Degenhardt, Christina Kuhn, Martina Rahmeh, Elisa Schmoeckel, Doris Mayr, Bastian Czogalla, Thomas Kolben, Sarah Meister, Sven Mahner, Udo Jeschke, Anna Hester
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2000 (2021)
Sialic acid-binding immunoglobulin-like lectins (Siglecs) are involved in various immune cell-mediated diseases. Their role in cancer is poorly investigated, and research focusses on Siglec-expression on immune cells interacting with tumor cells. Thi
Externí odkaz:
https://doaj.org/article/415de77bacd54881aec3c22c60b87707
Autor:
Bradford A. Youngblood, John Leung, Rustom Falahati, Jason Williams, Julia Schanin, Emily C. Brock, Bhupinder Singh, Alan T. Chang, Jeremy A. O’Sullivan, Robert P. Schleimer, Nenad Tomasevic, Christopher R. Bebbington, Bruce S. Bochner
Publikováno v:
Cells, Vol 10, Iss 1, p 19 (2020)
Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosi
Externí odkaz:
https://doaj.org/article/3a9df22d546640558f4cd6fc839dc654
Autor:
Girardi, Benedetta
This thesis principally focuses on the development of glycomimetic ligands with improved affinity to Siglec-8. Siglec-8 is a member of the Siglec family, I-type lectins that contain a sialic acid-binding domain and that play different roles in cell-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3505::18272efe0aced8bd2b06cb522e257ca3
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=143829
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=143829
