Siglec-9 Restrains Antibody-Dependent Natural Killer Cell Cytotoxicity against SARS-CoV-2

Autor: Pratima Saini, Opeyemi S. Adeniji, Devivasha Bordoloi, Jennifer Kinslow, Jeff Martinson, Danielle M. Parent, Kai Ying Hong, Jane Koshy, Abhijeet J. Kulkarni, Netanel F. Zilberstein, Robert A. Balk, James N. Moy, Leila B. Giron, Russell P. Tracy, Ali Keshavarzian, Kar Muthumani, Alan Landay, David B. Weiner, Mohamed Abdel-Mohsen

Publikováno v: mBio, Vol 14, Iss 1 (2023)

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection alters the immunological profiles of natural killer (NK) cells. However, whether NK antiviral functions are impaired during severe coronavirus disease 2019 (COVID-19) and

Externí odkaz: https://doaj.org/article/9b30c013c37148c591071bf5b0975101

Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities

Autor: Quentin Haas, Nikita Markov, Lukas Muerner, Viviana Rubino, Andrej Benjak, Monika Haubitz, Gabriela M. Baerlocher, Charlotte K. Y. Ng, Christian Münz, Carsten Riether, Adrian F. Ochsenbein, Hans-Uwe Simon, Stephan von Gunten

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

While inhibitory Siglec receptors are known to regulate myeloid cells, less is known about their expression and function in lymphocytes subsets. Here we identified Siglec-7 as a glyco-immune checkpoint expressed on non-exhausted effector memory CD8+

Externí odkaz: https://doaj.org/article/ee365483dca647a5aef0a91df47591e6

Siglec-7 Mediates Immunomodulation by Colorectal Cancer-Associated Fusobacterium nucleatum ssp. animalis

Autor: Dimitra Lamprinaki, Pilar Garcia-Vello, Roberta Marchetti, Charlotte Hellmich, Kelli A. McCord, Kristian M. Bowles, Matthew S. Macauley, Alba Silipo, Cristina De Castro, Paul R. Crocker, Nathalie Juge

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Fusobacterium nucleatum is involved in the development of colorectal cancer (CRC) through innate immune cell modulation. However, the receptors of the interaction between F. nucleatum ssp. and immune cells remain largely undetermined. Here, we showed

Externí odkaz: https://doaj.org/article/4819e070a92540a5acd7cd34751cb078

BGN/TLR4/NF-κB Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells

Autor: Hsiang-Chi Huang, Bi-He Cai, Ching-Shu Suen, Hsueh-Yi Lee, Ming-Jing Hwang, Fu-Tong Liu, Reiji Kannagi

Publikováno v: Cells, Vol 9, Iss 2, p 397 (2020)

Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-κB pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in colorect

Externí odkaz: https://doaj.org/article/1a6406e3ad7948dea84dd23140dd4e23

Siglec-7 May Limit Natural Killer Cell–mediated Antitumor responses in Bladder Cancer Patients

Autor: Valérie Cesson, Laurent Derré, Laura Villier, Beat Roth, Sulayman Benmerzoug, Anna K. Schneider, Patrice Jichlinski, Ilaria Lucca, Denise Nardelli-Haefliger, Mathieu F. Chevalier, Sylvain Nguyen, Sonia-Christina Rodrigues-Dias, Florence Dartiguenave

Publikováno v: European Urology Open Science
European urology open science, vol. 34, pp. 79-82
European Urology Open Science, Vol 34, Iss, Pp 79-82 (2021)

Aberrant glycosylation actively contributes to tumor progression and is a key hallmark of cancer. Most of the glycan moieties expressed on the surface of cancer cells are sialic acids that may modulate antitumor immune responses via binding to sialic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b15877383e1713eea5a3655c6cb85e
http://europepmc.org/articles/PMC8605422