Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Siglec‐15"'
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionSialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is a novel immune checkpoint, similar to programmed death-ligand (PD-L1), and has emerged as a potential target for cancer immunotherapy. Until recently, little was known about
Externí odkaz:
https://doaj.org/article/c6a9d7b4c0114e4e8658f6d8a563150a
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Inhibiting the PD-1/PD-L1 pathway using immunomodulators has demonstrated promising outcomes in clinics. Immunomodulators can effectively target immune checkpoints with a strong preference for the tumor microenvironment (TME). Besides, immunomodulato
Externí odkaz:
https://doaj.org/article/b0d64a5c348f456997d24f7261727c01
Publikováno v:
Materials Today Bio, Vol 29, Iss , Pp 101362- (2024)
Bone metastasis is a fatal consequence of breast cancer that occurs when patients fail to respond to conventional therapies and mainly result from a vicious cycle involving dysregulated bone homeostasis and uncontrolled tumor growth. Recent research
Externí odkaz:
https://doaj.org/article/b335412e4b234f0a9c78b97d050d87fb
Publikováno v:
Heliyon, Vol 10, Iss 21, Pp e38537- (2024)
Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is a well-conserved type I transmembrane protein of the Siglecs family, distributed in macrophages and dendritic cells in the human spleen and lymph nodes. As an immune receptor, Siglec-15
Externí odkaz:
https://doaj.org/article/0531bb51655044b499dbeb1cb28e53e8
Autor:
Xin‐Yu Zhang, Jian‐Bo Shi, Shu‐Fang Jin, Rui‐Jie Wang, Ming‐Yu Li, Zhi‐Yuan Zhang, Xi Yang, Hai‐Long Ma
Publikováno v:
Cancer Communications, Vol 44, Iss 6, Pp 670-694 (2024)
Abstract Background Metabolic reprograming and immune escape are two hallmarks of cancer. However, how metabolic disorders drive immune escape in head and neck squamous cell carcinoma (HNSCC) remains unclear. Therefore, the aim of the present study w
Externí odkaz:
https://doaj.org/article/e4dff3e90aa34ecf882fb99667f7199a
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract The sialic acid binding Ig like lectin 15 (Siglec-15) was previously identified as tumor immune suppressor gene in some human cancers with elusive molecular mechanism to be elucidated. The continuous focus on both clinical and basic biology
Externí odkaz:
https://doaj.org/article/bf8214056b9344bb85373b106e12a42b
Publikováno v:
The Clinical Respiratory Journal, Vol 18, Iss 5, Pp n/a-n/a (2024)
Abstract Sialic acid‐binding immunoglobulin‐like lectin‐15 (Siglec‐15) has been identified as an immune suppressor and a promising candidate for immunotherapy of cancer management. However, the association between Siglec‐15 expression and c
Externí odkaz:
https://doaj.org/article/9d3a97af8c0b423e8d60ef85453df9fa
Akademický článek
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Akademický článek
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Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background Sialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) has emerged as a novel immunotherapy candidate, which deserves a comprehensive investigation in lung adenocarcinoma (LUAD). Methods Multiplex fluorescence‐based immun
Externí odkaz:
https://doaj.org/article/2b082a33c9384673bbe0b3656b07ab23