Disclosing bias in bisulfite assay: MethPrimers underestimate high DNA methylation.

Autor: Andrea Fuso, Giampiero Ferraguti, Sigfrido Scarpa, Isidre Ferrer, Marco Lucarelli

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0118318 (2015)

Discordant results obtained in bisulfite assays using MethPrimers (PCR primers designed using MethPrimer software or assuming that non-CpGs cytosines are non methylated) versus primers insensitive to cytosine methylation lead us to hypothesize a tech

Externí odkaz: https://doaj.org/article/3d3d8cc501c1432c87d7f364ad446f36

PARP-1 modulates amyloid beta peptide-induced neuronal damage.

Autor: Sara Martire, Andrea Fuso, Dante Rotili, Italo Tempera, Cesare Giordano, Ivana De Zottis, Alessia Muzi, Patrizia Vernole, Grazia Graziani, Emanuela Lococo, Martina Faraldi, Bruno Maras, Sigfrido Scarpa, Luciana Mosca, Maria d'Erme

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e72169 (2013)

Amyloid beta peptide (Aβ) causes neurodegeneration by several mechanisms including oxidative stress, which is known to induce DNA damage with the consequent activation of poly (ADP-ribose) polymerase (PARP-1). To elucidate the role of PARP-1 in the

Externí odkaz: https://doaj.org/article/477c6d14022041cdbede9b0d3376fa6b

Exploring the brain tissue proteome of TgCRND8 Alzheimer's Disease model mice under B vitamin deficient diet induced hyperhomocysteinemia by LC-MS top-down platform

Autor: Federica Vincenzoni, Massimo Castagnola, Andrea Urbani, Andrea Fuso, Claudia Desiderio, Sigfrido Scarpa, Claudia Martelli, Rosaria A. Cavallaro, Daniela Delfino, Diana Valeria Rossetti, Ilaria Inserra

Publikováno v: Journal of chromatography. B
1124 (2019): 165–172. doi:10.1016/j.jchromb.2019.06.005
info:cnr-pdr/source/autori:Delfino, Daniela; Rossetti, Diana Valeria; Martelli, Claudia; Inserra, Ilaria; Vincenzoni, Federica; Castagnola, Massimo; Urbani, Andrea; Scarpa, Sigfrido; Fuso, Andrea; Cavallaro, Rosaria A.; Desiderio, Claudia/titolo:Exploring the brain tissue proteome of TgCRND8 Alzheimer's Disease model mice under B vitamin deficient diet induced hyperhomocysteinemia by LC-MS top-down platform/doi:10.1016%2Fj.jchromb.2019.06.005/rivista:Journal of chromatography. B (Print)/anno:2019/pagina_da:165/pagina_a:172/intervallo_pagine:165–172/volume:1124

The multifactorial nature of Late Onset Alzheimer's Disease (LOAD), the AD form of major relevance on epidemiological and social aspects, has driven the original investigation by LC-MS and top-down proteomics approach of the protein repertoire of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b97229c331d3340e91ce29501466e3a
http://hdl.handle.net/10807/153380

Plasma Thiols Levels in Alzheimer's Disease Mice under Diet-Induced Hyperhomocysteinemia: Effect of S-Adenosylmethionine and Superoxide-Dismutase Supplementation

Autor: Jacopo Gervasoni, Sigfrido Scarpa, Claudia Desiderio, Bruno Giardina, Silvia Persichilli, Rosaria A. Cavallaro, Vincenzina Nicolia, Alessandra Di Napoli, Andrea Fuso

Publikováno v: Journal of Alzheimer's disease 44 (2015): 1323–1331. doi:10.3233/JAD-142391
info:cnr-pdr/source/autori:Persichilli, Silvia; Gervasoni, Jacopo; Di Napoli, Alessandra; Fuso, Andrea; Nicolia, Vincenzina; Giardina, Bruno; Scarpa, Sigfrido; Desiderio, Claudia; Cavallaro, Rosaria A./titolo:Plasma Thiols Levels in Alzheimer's Disease Mice under Diet-Induced Hyperhomocysteinemia: Effect of S-Adenosylmethionine and Superoxide-Dismutase Supplementation/doi:10.3233%2FJAD-142391/rivista:Journal of Alzheimer's disease/anno:2015/pagina_da:1323/pagina_a:1331/intervallo_pagine:1323–1331/volume:44

Widely confirmed reports were published on association between hyperhomocysteinemia, B vitamin deficiency, oxidative stress, and amyloid-beta in Alzheimer's disease (AD). Homocysteine, cysteine, cysteinylglycine and glutathione are metabolically inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3318f6c46695fe407403456bbd08b0ba
https://doi.org/10.3233/jad-142391

Sexually dimorphic expression of reelin in the brain of a mouse model of Alzheimer disease

Autor: Maria Teresa Fiorenza, Gabor G. Kovacs, Viviana Ciraci, Sonia Canterini, Vincenzina Nicolia, Sigfrido Scarpa, Giampiero Palladino, Franco Mangia, Andrea Fuso

Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba74c2cff6ba1a327518c13905e44fd
http://hdl.handle.net/11573/908476