Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Sigan L. Hartley"'
Autor:
Emily K. Schworer, Benjamin L. Handen, Melissa Petersen, Sid O'Bryant, Jamie C. Peven, Dana L. Tudorascu, Laisze Lee, Sharon J. Krinsky‐McHale, Christy L. Hom, Isabel C. H. Clare, Bradley T. Christian, Nicole Schupf, Joseph H. Lee, Elizabeth Head, Mark Mapstone, Ira Lott, Beau M. Ances, Shahid Zaman, Adam M. Brickman, Florence Lai, H. Diana Rosas, Sigan L. Hartley, the Alzheimer Biomarker Consortium‐Down Syndrome
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION People with Down syndrome (DS) have a 75% to 90% lifetime risk of Alzheimer's disease (AD). AD pathology begins a decade or more prior to onset of clinical AD dementia in people with DS. It is not clear if plasma biomarkers of A
Externí odkaz:
https://doaj.org/article/13dbf3a21419485bb2909612d2c5af23
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2024)
IntroductionWithin two-parent households, the parent-couple subsystem (marital or romantic partner relationship) is posited to shape the mental health of both parents and children. Autistic children and their parents have an elevated-risk for mental
Externí odkaz:
https://doaj.org/article/876ffdec9d994b7181aed41ef693f2dd
Autor:
Jamie C. Peven, Benjamin L. Handen, Charles M. Laymon, Victoria Fleming, Brianna Piro-Gambetti, Bradley T. Christian, William Klunk, Ann D. Cohen, Ozioma Okonkwo, Sigan L. Hartley
Publikováno v:
Frontiers in Integrative Neuroscience, Vol 16 (2022)
Higher engagement in moderate-intensity physical activity (PA) is related to better cognitive functioning in neurotypical adults; however, little is known about the effect of PA on cognitive aging in adults with Down syndrome (DS). Individuals with D
Externí odkaz:
https://doaj.org/article/df0cac8f510d40ab84c6748acd4a3dd0
Autor:
Austin M. Bazydlo, Matthew D. Zammit, Minjie Wu, Patrick J. Lao, Douglas C. Dean, III, Sterling C. Johnson, Dana L. Tudorascu, Ann Cohen, Karly A. Cody, Beau Ances, Charles M. Laymon, William E. Klunk, Shahid Zaman, Benjamin L. Handen, Sigan L. Hartley, Andrew L. Alexander, Bradley T. Christian
Publikováno v:
NeuroImage: Clinical, Vol 33, Iss , Pp 102908- (2022)
Introduction: Individuals with Down syndrome (DS) are at an increased risk of developing Alzheimer’s Disease (AD). One of the early underlying mechanisms in AD pathology is the accumulation of amyloid protein plaques, which are deposited in extrace
Externí odkaz:
https://doaj.org/article/158dd7b6ead14a7fb884d639927e63a9
Autor:
Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian
Publikováno v:
NeuroImage, Vol 228, Iss , Pp 117728- (2021)
Introduction: Adults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and reveal early amyloid beta (Aβ) pathology in the brain. Positron emission tomography (PET) provides an in vivo measure of Aβ throughout the AD continuum. Du
Externí odkaz:
https://doaj.org/article/f793f64258bb45018fce502f5ace76f4
Autor:
Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Paul A. Ellison, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Marwan N. Sabbagh, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian
Publikováno v:
NeuroImage: Clinical, Vol 31, Iss , Pp 102740- (2021)
Introduction: Adults with Down syndrome are genetically predisposed to develop Alzheimer’s disease and accumulate beta-amyloid plaques (Aβ) early in life. While Aβ has been heavily studied in Down syndrome, its relationship with neurofibrillary t
Externí odkaz:
https://doaj.org/article/f466772638d948f6b49fdbd04232ca9b
Autor:
Matthew D. Zammit, Charles M. Laymon, Dana L. Tudorascu, Sigan L. Hartley, Brianna Piro‐Gambetti, Sterling C. Johnson, Charles K. Stone, Chester A. Mathis, Shahid H. Zaman, William E. Klunk, Benjamin L. Handen, Ann D. Cohen, Bradley T. Christian
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Adults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and the relationship between cognition and glucose metabolism in this population has yet to be evaluated. Methods Adults with DS (N = 90; mean age [stand
Externí odkaz:
https://doaj.org/article/2a745a8c1cfc4547bf4fcd09aabb4a72
Autor:
Sigan L. Hartley, Benjamin L. Handen, Darlynne Devenny, Dana Tudorascu, Brianna Piro‐Gambetti, Matthew D. Zammit, Charles M. Laymon, William E. Klunk, Shahid Zaman, Annie Cohen, Bradley T. Christian
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction There is a critical need to identify measures of cognitive functioning sensitive to early Alzheimer's disease (AD) pathophysiology in Down syndrome to advance clinical trial research in this at‐risk population. The objective o
Externí odkaz:
https://doaj.org/article/7e9aee3f603e4830a622701188593006
Autor:
Victoria Fleming, Brianna Piro-Gambetti, Austin Bazydlo, Matthew Zammit, Andrew L. Alexander, Bradley T. Christian, Benjamin Handen, David T. Plante, Sigan L. Hartley
Publikováno v:
Brain Sciences, Vol 11, Iss 10, p 1322 (2021)
Adults with Down syndrome are at a high risk for disordered sleep. These sleep problems could have marked effects on aging and Alzheimer’s disease, potentially altering white matter integrity. This study examined the associations between disordered
Externí odkaz:
https://doaj.org/article/73a537c88f0d45a19adaf8c3cdfab189
Autor:
Victoria Fleming, Brianna Piro‐Gambetti, Benjamin Handen, Bradley T. Christian, Annie Cohen, Dana Tudorascu, David T. Plante, Ozioma Okonkwo, Sigan L. Hartley
Publikováno v:
Journal of Policy and Practice in Intellectual Disabilities. 19:408-418
Adults with Down syndrome have an increased risk of aging-related physical and mental health conditions and experience them at an earlier age than the general population. There is a need to investigate modifiable lifestyle factors that may reduce ris