A Database Tool Integrating Genomic and Pharmacologic Data from Adrenocortical Carcinoma Cell Lines, PDX, and Patient Samples.

Autor: Arakawa Y; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Elloumi F; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Varma S; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Khandagale P; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Jo U; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Kumar S; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Roper N; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Reinhold WC; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Robey RW; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Takebe N; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Gottesman MM; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Thomas CJ; National Institutes of Health, Rockville, Maryland., Boeva V; Department of Computer Science, Institute for Machine Learning, ETH Zurich, Zurich, Switzerland., Berruti A; Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Medical Oncology Unit, University of Brescia, Azienda Socio Sanitaria Territoriale (ASST) Spedali Civili, Brescia, Italy., Abate A; Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Tamburello M; Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Sigala S; Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Hantel C; Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich, and University of Zurich, Zürich, Switzerland.; Medizinische Klinik und Poliklinik III, University Hospital Carl Gustav Carus Dresden, Dresden, Germany., Weigand I; Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany., Wierman ME; Department of Medicine-Endocrinology/Metabolism/Diabetes, University of Colorado, Anschutz Medical Campus, Aurora, Colorado., Kiseljak-Vassiliades K; Department of Medicine-Endocrinology/Metabolism/Diabetes, University of Colorado, Anschutz Medical Campus, Aurora, Colorado., Del Rivero J; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Pommier Y; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Publikováno v: Cancer research communications [Cancer Res Commun] 2024 Sep 01; Vol. 4 (9), pp. 2384-2398.

Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma.

Autor: Mariniello K; Centre for Endocrinology, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Pittaway JFH; Centre for Endocrinology, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Altieri B; Division of Endocrinology and Diabetes, Dept. of Medicine, University Hospital, University of Würzburg, 97080 Würzburg, Germany., Borges KS; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Hadjidemetriou I; Centre for Endocrinology, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Ribeiro C; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Ruiz-Babot G; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technical, University Dresden, Dresden, Germany., Lim JA; Centre for Endocrinology, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Foster J; Centre for Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ UK., Cleaver J; Centre for Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ UK., Sosabowski J; Centre for Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ UK., Rahman N; Institute of Biomedicine, University of Turku, Turku, Finland., Doroszko M; Institute of Biomedicine, University of Turku, Turku, Finland., Hantel C; Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), 8091 Zurich, Switzerland., Sigala S; Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25124 Brescia, Italy., Abate A; Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25124 Brescia, Italy., Tamburello M; Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25124 Brescia, Italy., Kiseljak-Vassiliades K; Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.; Division of Endocrinology, Metabolism and Diabetes at Rocky Mountain Regional Veterans Affair Medical Center, Washington, DC, USA., Wierman M; Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.; Division of Endocrinology, Metabolism and Diabetes at Rocky Mountain Regional Veterans Affair Medical Center, Washington, DC, USA., Parvanta L; Department of Surgery, St Bartholomew's Hospital, West Smithfield, London, EC1A 7BE, United Kingdom., Abdel-Aziz TE; Department of Surgery, University College London Hospitals NHS Foundation Trust, London NW1 2PG, United Kingdom., Chung TT; Department of Endocrinology, University College London Hospitals NHS Foundation Trust, London NW1 2PG, United Kingdom., Di Marco A; Department of Endocrine and Thyroid Surgery, Hammersmith Hospital, Imperial College London, London W12 0HS, United Kingdom., Palazzo F; Department of Endocrine and Thyroid Surgery, Hammersmith Hospital, Imperial College London, London W12 0HS, United Kingdom., Gomez-Sanchez CE; Endocrine Section, G.V. (Sonny) Montgomery VA Medical Center and the Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA., Taylor DR; Department of Clinical Biochemistry (Synnovis Analytics), King's College Hospital, London SE5 9RS, United Kingdom., Rayner O; Department of Clinical Biochemistry (Synnovis Analytics), King's College Hospital, London SE5 9RS, United Kingdom., Ronchi CL; Institute of Metabolism and System Research College of Medical and Dental Sciences, University of Birmingham, B15 2TT, United Kingdom., Gaston-Massuet C; Centre for Endocrinology, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Sbiera S; Division of Endocrinology and Diabetes, Dept. of Medicine, University Hospital, University of Würzburg, 97080 Würzburg, Germany., Drake WM; Centre for Endocrinology, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Rognoni E; Centre for Cell Biology & Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Kroiss M; Division of Endocrinology and Diabetes, Dept. of Medicine, University Hospital, University of Würzburg, 97080 Würzburg, Germany.; Department of Internal Medicine IV, LMU University Hospital, LMU Munich, Ziemssenstraße 5, 80336 München, Germany., Breault DT; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; Harvard Stem Cell Institute, Cambridge, Massachusetts., Fassnacht M; Division of Endocrinology and Diabetes, Dept. of Medicine, University Hospital, University of Würzburg, 97080 Würzburg, Germany., Guasti L; Centre for Endocrinology, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 22. Date of Electronic Publication: 2024 Aug 22.

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FSCN1 as a new druggable target in adrenocortical carcinoma.

Autor: Ruggiero C; Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR 7275, 06560, Valbonne, France.; Université Côte d'Azur, 06560, Valbonne, France., Tamburello M; Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25124, Brescia, Italy., Rossini E; Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25124, Brescia, Italy., Zini S; Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25124, Brescia, Italy., Durand N; Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR 7275, 06560, Valbonne, France.; Université Côte d'Azur, 06560, Valbonne, France., Cantini G; Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, 50134, Florence, Italy.; Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, 50134, Florence, Italy., Cioppi F; Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, 50134, Florence, Italy.; Department of Experimental and Clinical Medicine, University of Florence, 50134, Florence, Italy., Hantel C; Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), 8091, Zürich, Switzerland.; Medizinische Klinik und Poliklinik III, University Hospital Carl Gustav Carus Dresden, 01307, Dresden, Germany., Kiseljak-Vassiliades K; Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, 80045, Aurora, Colorado, USA.; Rocky Mountain Regional Veterans Affairs Medical Center, 80045, Aurora, Colorado, USA., Wierman ME; Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, 80045, Aurora, Colorado, USA.; Rocky Mountain Regional Veterans Affairs Medical Center, 80045, Aurora, Colorado, USA., Landwehr LS; Division of Endocrinology and Diabetology-Department of Internal Medicine I, University Hospital, University of Würzburg, 97080, Würzburg, Germany., Weigand I; Division of Endocrinology and Diabetology-Department of Internal Medicine I, University Hospital, University of Würzburg, 97080, Würzburg, Germany.; Department of Medicine IV, University Hospital Munich, Ludwig-Maximilians-Universität München, 81377, Munich, Germany., Kurlbaum M; Division of Endocrinology and Diabetology-Department of Internal Medicine I, University Hospital, University of Würzburg, 97080, Würzburg, Germany., Zizioli D; Section of Biotechnology, Department of Molecular and Translational Medicine, University of Brescia, 25124, Brescia, Italy., Turtoi A; Tumor Microenvironment and Resistance to Therapy Laboratory, Institut de Recherche en Cancérologie de Montpellier, Université de Montpellier-INSERM U1194, 34090, Montpellier, France.; Platform for Translational Oncometabolomics, Biocampus, CNRS-INSERM-Université de Montpellier, 34090, Montpellier, France., Yang S; Department of Cellular and Molecular Physiology, Penn State University College of Medicine, 17033, Hershey, Pennsylvania, USA., Berruti A; Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia and ASST Spedali Civili di Brescia, 25123, Brescia, Italy., Luconi M; Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, 50134, Florence, Italy.; Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, 50134, Florence, Italy., Sigala S; Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25124, Brescia, Italy., Lalli E; Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR 7275, 06560, Valbonne, France.; Université Côte d'Azur, 06560, Valbonne, France.; Inserm, 06560, Valbonne, France.

Publikováno v: International journal of cancer [Int J Cancer] 2023 Jul 01; Vol. 153 (1), pp. 210-223. Date of Electronic Publication: 2023 Mar 31.

Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness.

Autor: Monti M; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Benerini Gatta L; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.; Histocompatibility Laboratory 'Vittorio Mero', Department of Transfusion Medicine, ASST Spedali Civili Di Brescia, Brescia, Italy., Bugatti M; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Pezzali I; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Picinoli S; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Manfredi M; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.; Center for Autoimmune and Allergic Diseases, University of Piemonte Orientale, Novara, Italy., Lavazza A; Istituto Zooprofilattico Sperimentale Della Lombardia E Dell'Emilia-Romagna 'Bruno Ubertini', Brescia, Italy., Vanella VV; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.; Center for Autoimmune and Allergic Diseases, University of Piemonte Orientale, Novara, Italy., De Giorgis V; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.; Center for Autoimmune and Allergic Diseases, University of Piemonte Orientale, Novara, Italy., Zanatta L; Department of Pathology, Treviso Regional Hospital, Treviso, Italy., Missale F; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.; Department of Head & Neck Oncology & Surgery Otorhinolaryngology, Antoni Van Leeuwenhoek, Nederlands Kanker Instituut, Amsterdam, The Netherlands., Lonardi S; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Zanetti B; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Bozzoni G; Istituto Zooprofilattico Sperimentale Della Lombardia E Dell'Emilia-Romagna 'Bruno Ubertini', Brescia, Italy., Cadei M; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Abate A; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Vergani B; Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Balzarini P; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Battocchio S; Unit of Pathology, Department of Molecular and Translational Medicine, University of Brescia-'ASST Spedali Civili Di Brescia', Brescia, Italy., Facco C; Unit of Pathology, Department of Medicine and Surgery, ASST Sette-Laghi, University of Insubria, Varese, Italy., Turri-Zanoni M; Unit of Otorhinolaryngology and Head & Neck Surgery, Department of Biotechnology and Life Sciences, ASST Sette Laghi, University of Insubria, Varese, Italy., Castelnuovo P; Unit of Otorhinolaryngology and Head & Neck Surgery, Department of Biotechnology and Life Sciences, ASST Sette Laghi, University of Insubria, Varese, Italy., Nicolai P; Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, University of Padova, Padova, Italy., Fonsatti E; Medical Oncology and Immunotherapy, University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy., Leone BE; Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Marengo E; Department of Sciences and Technological Innovation, University of Piemonte Orientale, Alessandria, Italy., Sigala S; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Ronca R; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Perego M; The Wistar Institute, Philadelphia, PA, USA., Lombardi D; Unit of Otorhinolaryngology - Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Vermi W; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. william.vermi@unibs.it.; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA. william.vermi@unibs.it.; Department of Molecular and Translational Medicine, Section of Pathology, University of Brescia, P.Le Spedali Civili 1, 25123, Brescia, Italy. william.vermi@unibs.it.

Publikováno v: Journal of translational medicine [J Transl Med] 2024 Jan 08; Vol. 22 (1), pp. 35. Date of Electronic Publication: 2024 Jan 08.