Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model

Autor: Sylvie Cornet, Denis Carré, Lorenzo Limana, David Castel, Sigal Meilin, Ron Horne, Laurent Pons, Steven Evans, Stephane Lezmi, Mikhail Kalinichev

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)

Abstract Pain after surgery remains a significant healthcare challenge. Here, abobotulinumtoxinA (aboBoNT-A, DYSPORT) was assessed in a post-surgical pain model in pigs. Full-skin-muscle incision and retraction surgery on the lower back was followed

Externí odkaz: https://doaj.org/article/0c4fa2ed485b4986a2b991714148df4b

Reviving Matrix for Nerve Reconstruction in Rabbit Model of Chronic Peripheral Nerve Injury With Massive Loss Defect

Autor: Shimon Rochkind, Mara Almog, Sigal Meilin, Zvi Nevo

Publikováno v: Frontiers in Surgery, Vol 7 (2021)

Background and Aims: The aim of this study was to investigate the innovative guiding regenerative gel (GRG) and antigliotic GRG (AGRG) fillings for nerve conduits, prepared with Food and Drug Administration (FDA)-approved agents and expected to provi

Externí odkaz: https://doaj.org/article/6fc0c9562dd7490f86bf5f571e928ed2

Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice

Autor: Gal Ophir, Sigal Meilin, Margalit Efrati, Joab Chapman, Dimitri Karussis, Allen Roses, Daniel M Michaelson

Publikováno v: Neurobiology of Disease, Vol 12, Iss 1, Pp 56-64 (2003)

The allele E4 of apolipoprotein E (apoE) is an important risk factor for Alzheimer’s disease (AD) and the chronic brain inflammation which is associated with AD is more pronounced in subjects who carry this allele. In the present study, we employed

Externí odkaz: https://doaj.org/article/aa14c8444e1846f8acaf71a89d61fce5

Intraoperatively Administered AbobotulinumtoxinA Alleviates Pain After Surgery and Improves General Wellness in a Pig Model

Autor: Stephane Lezmi, Sylvie Cornet, Denis Carré, David Castel, Sigal Meilin, Ron Horne, Mikhail Kalinichev

Publikováno v: Toxicon. 214:S35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43d992f71affef49df88d30f15fb813f
https://doi.org/10.1016/j.toxicon.2021.11.080

A systematic review of porcine models in translational pain research

Autor: Suzan Meijs, Winnie Jensen, Sigal Meilin, Martin Schmelz

Publikováno v: Meijs, S, Schmelz, M, Meilin, S & Jensen, W 2021, ' A systematic review of porcine models in translational pain research ', Lab Animal, vol. 50, pp. 313-326 . https://doi.org/10.1038/s41684-021-00862-4

Translating basic pain research from rodents to humans has proven to be a challenging task. Efforts have been made to develop preclinical large animal models of pain, such as the pig. However, no consistent overview and comparison of pig models of pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aac8dfbdd1212621ea28daa62a266fa
https://pubmed.ncbi.nlm.nih.gov/34650279