Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Sigal Gery"'
Autor:
Yuan Jiang, Yueyuan Zheng, Yuan-Wei Zhang, Shuai Kong, Jinxiu Dong, Fei Wang, Benjamin Ziman, Sigal Gery, Jia-Jie Hao, Dan Zhou, Jianian Zhou, Allen S. Ho, Uttam K. Sinha, Jian Chen, Shuo Zhang, Chuntong Yin, Dan-Dan Wei, Masaharu Hazawa, Huaguang Pan, Zhihao Lu, Wen-Qiang Wei, Ming-Rong Wang, H. Phillip Koeffler, De-Chen Lin, Yan-Yi Jiang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Squamous cell carcinomas (SCCs) are common and aggressive malignancies. Immune check point blockade (ICB) therapy using PD-1/PD-L1 antibodies has been approved in several types of advanced SCCs. However, low response rate and treatment resis
Externí odkaz:
https://doaj.org/article/cf7285deb31c4f9bae07734dca4386f3
Autor:
Wenwen Chien, Jeffrey W. Tyner, Sigal Gery, Yueyuan Zheng, Li-Yan Li, Mohan Shankar Gopinatha Pillai, Chehyun Nam, Neil A. Bhowmick, De-Chen Lin, H. Phillip Koeffler
Publikováno v:
Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-14 (2023)
Abstract Background Standard platinum-based therapy for ovarian cancer is inefficient against ovarian clear cell carcinoma (OCCC). OCCC is a distinct subtype of epithelial ovarian cancer. OCCC constitutes 25% of ovarian cancers in East Asia (Japan, K
Externí odkaz:
https://doaj.org/article/085f030e8b1144f18f14b1e5bcb913e7
Autor:
Li-Yan Li, Qian Yang, Yan-Yi Jiang, Wei Yang, Yuan Jiang, Xiang Li, Masaharu Hazawa, Bo Zhou, Guo-Wei Huang, Xiu-E Xu, Sigal Gery, Ying Zhang, Ling-Wen Ding, Allen S. Ho, Zachary S. Zumsteg, Ming-Rong Wang, Melissa J. Fullwood, Stephen J. Freedland, Stephen J. Meltzer, Li-Yan Xu, En-Min Li, H. Phillip Koeffler, De-Chen Lin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The relevance and underlying molecular mechanisms of epigenetic regulation in squamous cell carcinomas (SCC) await further characterization. Here, the authors show a transcriptional regulatory loop involving SREBF1, TP63 and KLF5 driving tumourigenes
Externí odkaz:
https://doaj.org/article/bb5f76c06e2f4727bd8409644acda48f
Autor:
Ye Chen, Liang Xu, Anand Mayakonda, Mo-Li Huang, Deepika Kanojia, Tuan Zea Tan, Pushkar Dakle, Ruby Yu-Tong Lin, Xin-Yu Ke, Jonathan W. Said, Jianxiang Chen, Sigal Gery, Ling-Wen Ding, Yan-Yi Jiang, Angela Pang, Mark Edward Puhaindran, Boon Cher Goh, H. Phillip Koeffler
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Liposarcoma (LPS) is a rare cancer that can acquire resistance to chemotherapy. Here, the authors map super-enhancers in LPS, finding BET-protein dependent mechanisms that can be targeted by a BET protein degrader, which also can overcome acquired re
Externí odkaz:
https://doaj.org/article/737f0325add94122b8c3c1a96fabd32f
Autor:
Gabriele Gugliotta, Makoto Sudo, Qi Cao, De-Chen Lin, Haibo Sun, Sumiko Takao, Ronan Le Moigne, Mark Rolfe, Sigal Gery, Markus Müschen, Michele Cavo, H. Phillip Koeffler
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 10, Pp 750-761 (2017)
B acute lymphoblastic leukemia (B-ALL) cells are distinctively vulnerable to endoplasmic reticulum (ER) stress. Recently, inhibition of p97 was shown to induce ER stress and subsequently cell death in solid tumors and in multiple myeloma. We investig
Externí odkaz:
https://doaj.org/article/430d357f5769410d94ee2cbb17d44341
Autor:
H. Phillip Koeffler, Jiang Gu, Jonathan W. Said, Ngan B. Doan, Steven A. Miles, Rocio Alvarez, Ryoko Okamoto, Glenn D. Braunstein, Sigal Gery, Conghui Zhao, Yan Zhou
PDF - 60KB, Antibodies for Western blotting.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e2cc814b6749970f8e9f27467eb6af
https://doi.org/10.1158/1535-7163.22503465
https://doi.org/10.1158/1535-7163.22503465
Autor:
H. Phillip Koeffler, Jiang Gu, Jonathan W. Said, Ngan B. Doan, Steven A. Miles, Rocio Alvarez, Ryoko Okamoto, Glenn D. Braunstein, Sigal Gery, Conghui Zhao, Yan Zhou
PDF - 3892KB, Molecular structure of Cizotinib, Tivantinib, and SU11274.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1fa00a7544240f8108f9f24efb0e22
https://doi.org/10.1158/1535-7163.22503471.v1
https://doi.org/10.1158/1535-7163.22503471.v1
Autor:
H. Phillip Koeffler, Jiang Gu, Jonathan W. Said, Ngan B. Doan, Steven A. Miles, Rocio Alvarez, Ryoko Okamoto, Glenn D. Braunstein, Sigal Gery, Conghui Zhao, Yan Zhou
PDF - 3009KB, Effect of Tivantinib and Crizotinib on cell growth and c-MET phosphorylation of MDA-MB-231 and HT29 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd39dd89a0a0cf7d08e917572bbf6f0
https://doi.org/10.1158/1535-7163.22503468
https://doi.org/10.1158/1535-7163.22503468
Autor:
H. Phillip Koeffler, Jeffrey W. Tyner, Charles Forscher, Anand Mayakonda, Marilynn Chow, Sigal Gery, Jonathan W. Said, Ngan Doan, Huey Jin Lim, Victor Kwan Min Lee, David D. Gae, Brendan Pang, Qi Cao, De-Chen Lin, Haibo Sun
Fig. S1. GSEA analysis revealed significant enrichment of gene associated with genomic unstable EWS phenotype (A), cell cycle (B) and NF-κB (C) in SYK knockdown cells, and gene associated with metastasis (D) in cells treated with the SYK inhibitor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab0ab41a53fa1084607efb20ad68eda
https://doi.org/10.1158/1078-0432.22468367.v1
https://doi.org/10.1158/1078-0432.22468367.v1
Autor:
H. Phillip Koeffler, Jeffrey W. Tyner, Charles Forscher, Anand Mayakonda, Marilynn Chow, Sigal Gery, Jonathan W. Said, Ngan Doan, Huey Jin Lim, Victor Kwan Min Lee, David D. Gae, Brendan Pang, Qi Cao, De-Chen Lin, Haibo Sun
Purpose: Ewing sarcoma (EWS) is a devastating soft tissue sarcoma affecting predominantly young individuals. Tyrosine kinases (TK) and associated pathways are continuously activated in many malignancies, including EWS; these enzymes provide candidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93a0334472e77b8fec3e8e16dd0de64
https://doi.org/10.1158/1078-0432.c.6526913.v1
https://doi.org/10.1158/1078-0432.c.6526913.v1