Zobrazeno 1 - 10 of 39 pro vyhledávání: '"Sigal, Saphier"'
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Akademický článek
Species-specific lipophilicities of fluorinated diketones in complex equilibria systems and their potential as multifaceted reversible covalent warheads
Autor: Ishay Columbus, Lee Ghindes-Azaria, Ido Michael Herzog, Eliav Blum, Galit Parvari, Yoav Eichen, Yoram Cohen, Eytan Gershonov, Eyal Drug, Sigal Saphier, Shlomi Elias, Boris Smolkin, Yossi Zafrani
Publikováno v: Communications Chemistry, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Combined molecular, physicochemical and chemical properties of electrophilic warheads can be applied to create covalent drugs with diverse facets. Here we study these properties in fluorinated diketones (FDKs) and their multicomponent equili
Externí odkaz: https://doaj.org/article/a860ffa0df394bef8d48ba40fbb9360a
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3
Poly(vinyl alcohol)‐methacrylate with CRGD peptide: A photocurable biocompatible hydrogel
Autor: Osnat Rosen, Shahaf Katalan, Avital Jayson, Sigal Saphier, Niva Natan, Eyal Epstein, Michael Goldvaser, Oded Shoseyov, Tal Ben-Shalom
Publikováno v: Journal of Tissue Engineering and Regenerative Medicine. 16:140-150
Polyvinyl alcohol (PVA)-based hydrogels are promising biomaterials for tissue engineering printing applications. However, one of their main disadvantages is their inability to support cell attachment, which is a critical feature for the preparation o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ba830a5e205a7b117c98d9262b65c3
https://doi.org/10.1002/term.3265
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5
Placing CF
Autor: Sigal, Saphier, Shahaf, Katalan, Guy, Yacov, Anat, Berliner, Orit, Redy-Keisar, Gil, Fridkin, Lee, Ghindes-Azaria, Ishay, Columbus, Alexander, Pevzner, Eyal, Drug, Hagit, Prihed, Eytan, Gershonov, Yoav, Eichen, Shlomi, Elias, Galit, Parvari, Yossi, Zafrani
Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany).
Fluorine atoms play an important role in all branches of chemistry and accordingly, it is very important to study their unique and varied effects systematically, in particular, the structure-physicochemical properties relationship. The present study
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::942ea5441aafe3565baf4a76cee609a2
https://pubmed.ncbi.nlm.nih.gov/36374157
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7
A biomimetic platform for studying root-environment interaction
Autor: Denise Caldwell, Sigal Saphier, Sigal Brown Miyara, Maya Kleiman, Anjali S. Iyer-Pascuzzi, Patricia Bucki, Neta Ginzburg, Tali Sayas, Pallavi Kumari
Publikováno v: Plant and Soil. 447:157-168
Aims Microstructure plays an important role in biological systems. Microstructural features are critical in the interaction between two biological organisms, for example, a microorganism and the surface of a plant. However, isolating the structural e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1cf1f2c01b6265b3a3fcb72162225e1
https://doi.org/10.1007/s11104-019-04390-6
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8
CF2H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH3?
Autor: Daniele Marciano, Yossi Zafrani, Dafna Amir, Gali Sod-Moriah, Nissan Ashkenazi, Shlomi Elias, Moran Madmon, Dina Yeffet, Eytan Gershonov, Anat Berliner, Shahaf Katalan, Sigal Saphier
Publikováno v: Journal of Medicinal Chemistry. 62:5628-5637
The effects of the CF2H moiety on H-bond acidity and lipophilicity of various compounds, when attached directly to an aromatic ring or to other functions like alkyls, ethers/thioethers or electron withdrawing groups, are discussed. It was found that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ff9dbfdccf5cf2d24cc845efd8c8e21
https://doi.org/10.1021/acs.jmedchem.9b00604
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9
Modulation of the H-Bond Basicity of Functional Groups by α-Fluorine-Containing Functions and its Implications for Lipophilicity and Bioisosterism
Autor: Shahaf Katalan, Eytan Gershonov, Yossi Zafrani, Yoav Eichen, Galit Parvari, Lee Ghindes-Azaria, Shlomi Elias, Sigal Saphier, Anat Berliner, Alexander Pevzner, Gil Fridkin, Dafna Amir
Publikováno v: Journal of medicinal chemistry. 64(8)
Modulation of the H-bond basicity (pKHB) of various functional groups (FGs) by attaching fluorine functions and its impact on lipophilicity and bioisosterism considerations are described. In general, H/F replacement at the α-position to H-bond accep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a5bb2e33830fe51850db0c904c2617
https://pubmed.ncbi.nlm.nih.gov/33844540
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10
The Effect of Anesthetic Regimens on Intestinal Absorption of Passively Absorbed Drugs in Rats
Autor: Ziv Klausner, Ada Wenger, Michael Goldvaser, Sigal Saphier, Guy Yacov, Shahaf Katalan, Amir Rosner
Publikováno v: Pharmaceutical Research. 37
Different anesthetic regimens are used during single pass intestinal perfusion (SPIP) experiments for the study of intestinal drug absorption in rats. We examined the ketamine/xylazine anesthetic combination to evaluate its influence on drug absorpti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc99ba9ce06f4d8114db6f93fdc84d4
https://doi.org/10.1007/s11095-020-02809-9
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