Zobrazeno 1 - 10
of 357
pro vyhledávání: '"Siewert J, Marrink"'
Autor:
Anna M. Borowska, Maria Gabriella Chiariello, Alisa A. Garaeva, Jan Rheinberger, Siewert J. Marrink, Cristina Paulino, Dirk J. Slotboom
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract ASCT2 is an obligate exchanger of neutral amino acids, contributing to cellular amino acid homeostasis. ASCT2 belongs to the same family (SLC1) as Excitatory Amino Acid Transporters (EAATs) that concentrate glutamate in the cytosol. The mech
Externí odkaz:
https://doaj.org/article/9fd4fa60482e4bd8bd187afb119c679a
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-7 (2024)
Abstract Biomolecular condensates are phase separated systems that play an important role in the spatio-temporal organisation of cells. Their distinct physico-chemical nature offers a unique environment for chemical reactions to occur. The compartmen
Externí odkaz:
https://doaj.org/article/d0aaec80f15c4da5b5277b2bb7baa3a7
Autor:
Peter Park, Danilo K. Matsubara, Domenico R. Barzotto, Filipe S. Lima, Hernan Chaimovich, Siewert J. Marrink, Iolanda M. Cuccovia
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Short-cationic alpha-helical antimicrobial peptides (SCHAMPs) are promising candidates to combat the growing global threat of antimicrobial resistance. They are short-sequenced, selective against bacteria, and have rapid action by destroying
Externí odkaz:
https://doaj.org/article/5db4d88ea50249fe9321e61dccbbc911
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114110- (2024)
Summary: Transmembrane transporter proteins are essential for maintaining cellular homeostasis and, as such, are key drug targets. Many transmembrane transporter proteins are known to undergo large structural rearrangements during their functional cy
Externí odkaz:
https://doaj.org/article/981068598b8847a4a08dbaa2b43d9608
Autor:
Eleonora Diamanti, Paulo C. T. Souza, Inda Setyawati, Spyridon Bousis, Leticia Monjas, Lotteke J.Y.M. Swier, Atanaz Shams, Aleksei Tsarenko, Weronika K. Stanek, Manuel Jäger, Siewert J. Marrink, Dirk J. Slotboom, Anna K. H. Hirsch
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-8 (2023)
Abstract The energy-coupling factor (ECF) transporters are a family of transmembrane proteins involved in the uptake of vitamins in a wide range of bacteria. Inhibition of the activity of these proteins could reduce the viability of pathogens that de
Externí odkaz:
https://doaj.org/article/cb7fa63baaae402daad67c5aaefc6bbd
Autor:
Apilaasha Tharmasothirajan, Josef Melcr, John Linney, Thomas Gensch, Karin Krumbach, Karla Marlen Ernst, Christopher Brasnett, Paola Poggi, Andrew R. Pitt, Alan D. Goddard, Alexandros Chatgilialoglu, Siewert J. Marrink, Jan Marienhagen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Microbial synthesis of nutraceutically and pharmaceutically interesting plant polyphenols represents a more environmentally friendly alternative to chemical synthesis or plant extraction. However, most polyphenols are cytotoxic for microorga
Externí odkaz:
https://doaj.org/article/1b0e48c69d814fe79319a30d5008f67e
Autor:
Chancievan Thangaratnarajah, Mark Nijland, Luís Borges-Araújo, Aike Jeucken, Jan Rheinberger, Siewert J. Marrink, Paulo C. T. Souza, Cristina Paulino, Dirk J. Slotboom
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Energy-coupling factor (ECF)-type transporters mediate the uptake of micronutrients in many bacteria. They consist of a substrate-translocating subunit (S-component) and an ATP-hydrolysing motor (ECF module) Previous data indicate that the S
Externí odkaz:
https://doaj.org/article/a86a02f4371e40bf9108dd6718f5be87
Autor:
Adéla Melcrová, Sourav Maity, Josef Melcr, Niels A. W. de Kok, Mariella Gabler, Jonne van der Eyden, Wenche Stensen, John S. M. Svendsen, Arnold J. M. Driessen, Siewert J. Marrink, Wouter H. Roos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Antimicrobial resistance is one of the leading concerns in medical care. Here we study the mechanism of action of an antimicrobial cationic tripeptide, AMC-109, by combining high speed-atomic force microscopy, molecular dynamics, fluorescenc
Externí odkaz:
https://doaj.org/article/dc03a19cfff44e7683a6bac15ecc3668
Autor:
Barbora Waclawiková, Paulo Cesar Telles de Souza, Markus Schwalbe, Constantinos G. Neochoritis, Warner Hoornenborg, Sieger A. Nelemans, Siewert J. Marrink, Sahar El Aidy
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTIntestinal microbiota and microbiota-derived metabolites play a key role in regulating the host physiology. Recently, we have identified a gut-bacterial metabolite, namely 5-hydroxyindole, as a potent stimulant of intestinal motility via its
Externí odkaz:
https://doaj.org/article/bfc4e2f6d78e4fee9419d2cb3d2f3e4a
Autor:
Benjamin R. Gilbert, Zane R. Thornburg, Troy A. Brier, Jan A. Stevens, Fabian Grünewald, John E. Stone, Siewert J. Marrink, Zaida Luthey-Schulten
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Computational models of cells cannot be considered complete unless they include the most fundamental process of life, the replication and inheritance of genetic material. By creating a computational framework to model systems of replicating bacterial
Externí odkaz:
https://doaj.org/article/42b2539a78d14ebabeca3d47e234ce28