Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Siew-Siew Pang"'
Autor:
Bradley A. Spicer, Ruby H. P. Law, Tom T. Caradoc-Davies, Sue M. Ekkel, Charles Bayly-Jones, Siew-Siew Pang, Paul J. Conroy, Georg Ramm, Mazdak Radjainia, Hariprasad Venugopal, James C. Whisstock, Michelle A. Dunstone
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
The Complement component 9 (C9) is the pore-forming component of the Membrane Attack Complex which targets pathogens. Here authors use structural biology to compare monomeric C9 to C9 within the polymeric assembly and identify the element which inhib
Externí odkaz:
https://doaj.org/article/786ad92e96b04d58a33f04be085b9901
Autor:
Charles Bayly-Jones, Siew Siew Pang, Bradley A. Spicer, James C. Whisstock, Michelle A. Dunstone
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Macrophage-expressed gene 1 [MPEG1/Perforin-2 (PRF2)] is an ancient metazoan protein belonging to the Membrane Attack Complex/Perforin (MACPF) branch of the MACPF/Cholesterol Dependent Cytolysin (CDC) superfamily of pore-forming proteins (PFPs). MACP
Externí odkaz:
https://doaj.org/article/4a28db91836141f8abd5ad2c881d9efd
Autor:
Salimeh Ebrahimnezhaddarzi, Catherina H Bird, Cody C Allison, Daniel E Tuipulotu, Xenia Kostoulias, Christophe Macri, Michael D Stutz, Gilu Abraham, Dion Kaiserman, Siew Siew Pang, Si Ming Man, Justine D Mintern, Thomas Naderer, Anton Y Peleg, Marc Pellegrini, James C Whisstock, Phillip I Bird
Publikováno v:
Immunology & Cell Biology. 100:529-546
To control infections phagocytes can directly kill invading microbes. Macrophage-expressed gene 1 (Mpeg1), a pore-forming protein sometimes known as perforin-2, is reported to be essential for bacterial killing following phagocytosis. Mice homozygous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee1949a71f00de27132bd4e4d0a5002
https://doi.org/10.1111/imcb.12554
https://doi.org/10.1111/imcb.12554
Autor:
Phillip I. Bird, Bart W. Hoogenboom, Adrian W. Hodel, Georg Ramm, Susan M. Ekkel, Hariprasad Venugopal, Charles Bayly-Jones, Mazdak Radjainia, Ilia Voskoboinik, Ruby H. P. Law, Paul J. Conroy, Yann Gambin, Siew Siew Pang, Michelle A. Dunstone, Emma Sierecki, Bradley A. Spicer, Edward S. Parsons, James C. Whisstock
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
Nature Communications
Macrophage-expressed gene 1 (MPEG1/Perforin-2) is a perforin-like protein that functions within the phagolysosome to damage engulfed microbes. MPEG1 is thought to form pores in target membranes, however, its mode of action remains unknown. We use cry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d562c790b77ea9ee8829a74700201af
https://doaj.org/article/2cd82268e003405ba51038290da8f4fe
https://doaj.org/article/2cd82268e003405ba51038290da8f4fe
Autor:
Bart W. Hoogenboom, Siew Siew Pang, Mazdak Radjainia, Hariprasad Venugopal, Georg Ramm, Ruby H. P. Law, Yann Gambin, Emma Sierecki, Ilia Voskoboinik, Bradley A. Spicer, Michelle A. Dunstone, James C. Whisstock, Sue M. Ekkel, Phillip I. Bird, Charles Bayly-Jones, Paul J. Conroy, Adrian W. Hodel
Macrophage Expressed Gene-1 (MPEG-1; also termed Perforin-2) is an endosomal / phagolysosomal perforin-like protein that is conserved across the metazoan kingdom and that functions within the phagolysosome to damage engulfed microbes. Like the Membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecea4831a0447841f9fae144e12c4aac
Autor:
Michelle A. Dunstone, Tom T. Caradoc-Davies, James C. Whisstock, Charles Bayly-Jones, Mazdak Radjainia, Ruby H. P. Law, Hariprasad Venugopal, Paul J. Conroy, Georg Ramm, Bradley A. Spicer, Siew Siew Pang, Sue M. Ekkel
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
Complement component 9 (C9) functions as the pore-forming component of the Membrane Attack Complex (MAC). During MAC assembly, multiple copies of C9 are sequentially recruited to membrane associated C5b8 to form a pore. Here we determined the 2.2 Å
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792eddd3ce29236fee85647ad5b5f8fa
http://europepmc.org/articles/PMC6093860
http://europepmc.org/articles/PMC6093860
Autor:
Emilie Lameignere, Sheareen Tan, Edward M. Conway, Anna M. Blom, James C. Whisstock, Lilian Hor, Robert N. Pike, Xuyu Liu, Frida C. Mohlin, Lakshmi C. Wijeyewickrema, Siew Siew Pang, Richard J. Payne
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 199(11)
Complement is crucial to the immune response, but dysregulation of the system causes inflammatory disease. Complement is activated by three pathways: classical, lectin, and alternative. The classical and lectin pathways are initiated by the C1r/C1s (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d418bb823416c2fafe54add4eeca91d0
https://pubmed.ncbi.nlm.nih.gov/29061764
https://pubmed.ncbi.nlm.nih.gov/29061764
Autor:
Siew Siew Pang1, Berry, Richard1, Zhenjun Chen2, Lars Kjer-Nielsen2, Matthew A. Perugini3, King, Glenn F.4, Christina Wang1, Sock Hui Chew1, La Gruta, Nicole L.2, Williams, Neal K.1, Beddoe, Travis1, Tiganis, Tony1, Cowieson, Nathan P.5, Godfrey, Dale I.2, Purcell, Anthony W.3, Wilce, Matthew C. J.1, McCluskey, James2, Rossjohn, Jamie1
Publikováno v:
Nature. 10/14/2010, Vol. 467 Issue 7317, p844-848. 5p. 3 Diagrams, 2 Graphs.
Autor:
Dale I. Godfrey, Laurent Gapin, Steven A. Porcelli, Santosh Keshipeddy, James McCluskey, Siew Siew Pang, Mary H. Young, Onisha Patel, Stewart K. Richardson, Meena Thakur, Adam P Uldrich, Jamie Rossjohn, Andrew G. Brooks, Petr A. Illarionov, Amy R. Howell, Gurdyal S. Besra, Lucy C. Sullivan, Kwok Soon Wun, Daniel G. Pellicci, Garth Cameron
Publikováno v:
Immunity. 34:327-339
SummaryNatural killer T (NKT) cells respond to a variety of CD1d-restricted antigens (Ags), although the basis for Ag discrimination by the NKT cell receptor (TCR) is unclear. Here we have described NKT TCR fine specificity against several closely re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499024fb522979dd5d429ad6ea5766bd
https://doi.org/10.1016/j.immuni.2011.02.001
https://doi.org/10.1016/j.immuni.2011.02.001
Autor:
Lars Kjer-Nielsen, Travis Clarke Beddoe, Anthony W. Purcell, Tony Tiganis, M.C. Wilce, Nicole L. La Gruta, Glenn F. King, Richard Berry, Chunxiao (Christina) Wang, Sock Hui Chew, Matthew A. Perugini, Jamie Rossjohn, Siew Siew Pang, Neal Kenneth Williams, Zhenjun Chen, James McCluskey, Nathan Cowieson, Dale I. Godfrey
Publikováno v:
Nature. 467:844-848
The pre-T-cell antigen receptor (pre-TCR), expressed by immature thymocytes, has a pivotal role in early T-cell development, including TCR β-selection, survival and proliferation of CD4−CD8− double-negative thymocytes, and subsequent αβ T-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff74cca64a30ee9722f45047a53ff10
https://doi.org/10.1038/nature09448
https://doi.org/10.1038/nature09448