Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Siew-Pheng Lim"'
Autor:
Ricardo Martín Gómez, Eugenio Antonio Carrera Silva, Jônatas Santos Abrahão, Siew Pheng Lim, Aleem Siddiqui
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Externí odkaz:
https://doaj.org/article/c3b93194e5e9479da4e485214554bfd5
Autor:
C. S. Brian Chia, Siew Pheng Lim
Publikováno v:
ChemMedChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aeedd3ccb3c38eb1c4b0da7917f07b2
https://doi.org/10.1002/cmdc.202300216
https://doi.org/10.1002/cmdc.202300216
Autor:
Siew Pheng Lim, Pei-Yong Shi
Publikováno v:
Viruses, Vol 5, Iss 12, Pp 2977-3006 (2013)
The outbreak of West Nile virus (WNV) in 1999 in the USA, and its continued spread throughout the Americas, parts of Europe, the Middle East and Africa, underscored the need for WNV antiviral development. Here, we review the current status of WNV dru
Externí odkaz:
https://doaj.org/article/2f9711e695bc4f72bafe1924e4dafca2
Autor:
Siew Pheng Lim, Christian Guy Noble, Cheah Chen Seh, Tingjin Sherryl Soh, Abbas El Sahili, Grace Kar Yarn Chan, Julien Lescar, Rishi Arora, Timothy Benson, Shahul Nilar, Ujjini Manjunatha, Kah Fei Wan, Hongping Dong, Xuping Xie, Pei-Yong Shi, Fumiaki Yokokawa
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005737 (2016)
Flaviviruses comprise major emerging pathogens such as dengue virus (DENV) or Zika virus (ZIKV). The flavivirus RNA genome is replicated by the RNA-dependent-RNA polymerase (RdRp) domain of non-structural protein 5 (NS5). This essential enzymatic act
Externí odkaz:
https://doaj.org/article/9bed2e761e8c4eac932cd102650b701a
Autor:
Siew Pheng Lim
Publikováno v:
Antiviral Research. 210:105514
Despite the availability of vaccines and therapeutics, continual genetic alterations render the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) a persistent threat, particularly for the immunocompromised and elderly. Through interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f281c5c850b5ea903c4718a8db1944a1
https://doi.org/10.1016/j.antiviral.2022.105514
https://doi.org/10.1016/j.antiviral.2022.105514
Autor:
Yongqian Zhao, Tingjin Sherryl Soh, Jie Zheng, Kitti Wing Ki Chan, Wint Wint Phoo, Chin Chin Lee, Moon Y F Tay, Kunchithapadam Swaminathan, Tobias C Cornvik, Siew Pheng Lim, Pei-Yong Shi, Julien Lescar, Subhash G Vasudevan, Dahai Luo
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004682 (2015)
Flavivirus RNA replication occurs within a replication complex (RC) that assembles on ER membranes and comprises both non-structural (NS) viral proteins and host cofactors. As the largest protein component within the flavivirus RC, NS5 plays key enzy
Externí odkaz:
https://doaj.org/article/09f9d10f4cb74468adf79b0cf96ece1c
Autor:
Siew Pheng Lim, Alfredo Garzino-Demo
Publikováno v:
BioTechniques, Vol 28, Iss 1, Pp 124-130 (2000)
Novel secreted and/or type I transmembrane proteins containing N-terminal signal sequences have been successfully cloned using the signal sequence trapping (SST) method. Often this involves random cloning of short 5′ cDNA terminal ends into an epit
Externí odkaz:
https://doaj.org/article/4d0298df077740679f4011abfaf474a2
Autor:
Haoying Xu, Wei Lin Sandra Sim, Cheah Chen Seh, Feng Wang, Thierry T. Diagana, Wai Ling Chan, Jae-Geun Song, Kah Fei Wan, Bin Zou, Ghislain M. C. Bonamy, David Beer, David T. Barkan, Min Li, Stephanie A. Moquin, Francesca Blasco, Suresh B. Lakshminarayana, Jin Zhang, Oliver Simon, Vito G. Sasseville, Craig W. Day, Qing-Yin Wang, Chandrassegar Saravanan, Katherine Chan, Fumiaki Yokokawa, Bryan K. S. Yeung, Ratna Karuna, Hui-Quan Yeo, Colin Osborne, Christopher Sarko, Pei Yong Shi, Hongping Dong, Mei Ding, Siew Pheng Lim, Yen Liang Chen, Feng Gu, Cyrille Kounde, Gang Wang, Siyan Lu, Wei Liu
Publikováno v:
Science Translational Medicine. 13
Dengue virus (DENV) is a mosquito-borne flavivirus that poses a threat to public health, yet no antiviral drug is available. We performed a high-throughput phenotypic screen using the Novartis compound library and identified candidate chemical inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88cb7c9fc29a66acc799682b5292b913
https://doi.org/10.1126/scitranslmed.abb2181
https://doi.org/10.1126/scitranslmed.abb2181
Autor:
Cheah Chen Seh, Chong Wai Liew, Pei Yong Shi, Gang Wang, Christian G. Noble, Timothy E. Benson, Tingjin Sherryl Soh, Thomas M. Smith, Fumiaki Yokokawa, Julien Lescar, Rishi Arora, Kimberley Yue, Siew Pheng Lim, Yen Liang Chen, Dorcas Adobea Otoo, Shahul Nilar
Publikováno v:
J Virol
Dengue virus (DENV) NS5 RNA-dependent RNA polymerase (RdRp), an important drug target, synthesizes viral RNA and is essential for viral replication. While a number of allosteric inhibitors have been reported for hepatitis C virus RdRp, few have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1473a77a1e522eda22a54f899c157f
https://doi.org/10.1128/jvi.01130-20
https://doi.org/10.1128/jvi.01130-20
Autor:
Martijn Fenaux, Andrea Leonardi, Sreehari Babu, Peck Gee Seah, Wei Liu, Pei Yong Shi, Rao P S Srinivasa, Suresh B. Lakshminarayana, Haoying Xu, Jin Zhang, Fumiaki Yokokawa, Cheah Chen Seh, Francesca Blasco, Nahdiyah Abdul Ghafar, Wai Ling Chan, Gang Wang, Ellie Growcott, Feng Gu, Weidong Zhong, Keshi Wang, Mei Ding, Ratna Karuna, Siew Pheng Lim, Yen Liang Chen
Publikováno v:
Antimicrob Agents Chemother
Monophosphate prodrug analogs of 2′-deoxy-2′-fluoro-2′-C-methylguanosine have been reported as potent inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase. These prodrugs also display potent anti-dengue virus activities in cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18dd646098b1cf2a7e9cd9dd08f0a432
https://europepmc.org/articles/PMC7674056/
https://europepmc.org/articles/PMC7674056/
