Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Siew Kwan Koh"'
Autor:
Jia Yi Kimberly Low, Xiangyan Shi, Venkatraman Anandalakshmi, Dawn Neo, Gary Swee Lim Peh, Siew Kwan Koh, Lei Zhou, M. K. Abdul Rahim, Ketti Boo, JiaXuan Lee, Harini Mohanram, Reema Alag, Yuguang Mu, Jodhbir S. Mehta, Konstantin Pervushin
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
ATP-independent amyloid-β chaperone L-PGDS disaggregates corneal amyloids in surgically excised human cornea of TGFBI-related corneal dystrophy patients by recognizing and releasing structurally frustrated regions.
Externí odkaz:
https://doaj.org/article/28fdb71f9bbb4ac495fc11425d4791b0
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Palmitoylation is a dynamic process that regulates the activity of the modified proteins. Retinal pigment epithelial (RPE) cells play pivotal roles in the visual cycle and maintaining healthy photoreceptor cells. Dysfunctional RPE cells are often ass
Externí odkaz:
https://doaj.org/article/1b4b0ab7692f45d3956a530e6aa46267
Autor:
Yu-Chi Liu, Gary Hin-Fai Yam, Molly Tzu-Yu Lin, Ericia Teo, Siew-Kwan Koh, Lu Deng, Lei Zhou, Louis Tong, Jodhbir S. Mehta
Publikováno v:
Journal of Advanced Research, Vol 29, Iss , Pp 67-81 (2021)
Introduction: The tear proteomics and neuromediators are associated with clinical dry eye parameters following refractive surgery. Purpose: To investigate and compare the tear proteomic and neuromediator profiles following small incision lenticule ex
Externí odkaz:
https://doaj.org/article/20059135a66a4cd485eb44db2ff370e3
Autor:
Calesta Hui Yi Teo, Molly Tzu-Yu Lin, Isabelle Xin Yu Lee, Siew-Kwan Koh, Lei Zhou, Dylan Shaoying Goh, Hyungwon Choi, Hiromi Wai Ling Koh, Amanda Yun Rui Lam, Paik Shia Lim, Jodhbir S. Mehta, Jean-Paul Kovalik, Thomas M. Coffman, Hong Chang Tan, Yu-Chi Liu
Publikováno v:
Diabetes.
Diabetic corneal neuropathy (DCN) is a common complication of diabetes mellitus (DM). However, there are very limited therapeutic options. We investigated the effects of a peroxisome proliferator-activated receptor-alpha (PPAR)-α agonist, fenofibrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6f404b03cb0254b2c07992b0b99cf1
https://pubmed.ncbi.nlm.nih.gov/36445944
https://pubmed.ncbi.nlm.nih.gov/36445944
Autor:
Jian Wei Teng, Mei Lin Go, Lloyd Wei Tat Tang, Hao Fan, Ravi Kumar Verma, Eric Chun Yong Chan, Lei Zhou, Siew Kwan Koh
Publikováno v:
Drug Metabolism and Disposition. 49:856-868
Infigratinib (INF) is a promising selective inhibitor of fibroblast growth factor receptors 1-3 that has recently been accorded both orphan drug designation and priority review status by the U.S Food and Drug Administration for the treatment of advan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5efa437f38ef0c673c780016c9dc5a
https://doi.org/10.1124/dmd.121.000508
https://doi.org/10.1124/dmd.121.000508
Autor:
Lloyd Wei Tat Tang, Wan Wei, Ravi Kumar Verma, Siew Kwan Koh, Lei Zhou, Hao Fan, Eric Chun Yong Chan
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::430c05225d14b3fead0cd5932677c23f
https://doi.org/10.1096/fasebj.2022.36.s1.0r684
https://doi.org/10.1096/fasebj.2022.36.s1.0r684
Autor:
Louis Tong, Siew-Kwan Koh, Gary Hin-Fai Yam, Lei Zhou, Lu Deng, Molly Tzu-Yu Lin, Yu-Chi Liu, Ericia Teo, Jodhbir S. Mehta
Publikováno v:
Journal of Advanced Research
Journal of Advanced Research, Vol 29, Iss, Pp 67-81 (2021)
Journal of Advanced Research, Vol 29, Iss, Pp 67-81 (2021)
Graphical abstract
Introduction The tear proteomics and neuromediators are associated with clinical dry eye parameters following refractive surgery. Purpose To investigate and compare the tear proteomic and neuromediator profiles following small
Introduction The tear proteomics and neuromediators are associated with clinical dry eye parameters following refractive surgery. Purpose To investigate and compare the tear proteomic and neuromediator profiles following small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ee6331828b74fd9904651b4d73ed59
http://europepmc.org/articles/PMC8020296
http://europepmc.org/articles/PMC8020296
Autor:
Qingxiao Xi, Jayasudha Varadarajan, Siew Kwan Koh, Roger W. Beuerman, Eunice Tze Leng Goh, Navin Kumar Verma, Venkatesh Mayandi, Lei Zhou, Rajamani Lakshminarayanan, Darren Shu Jeng Ting, Rupesh Agrawal, Timothy Barkham, Madhavi Latha Somaraju Chalasani, Veluchamy A Barathi, Thomas Yong Jie Toh, Mobashar Hussain Urf Turabe Fazil, Lai Wah Chan
Publikováno v:
Journal of Medicinal Chemistry. 63:3522-3537
Here, we present a rational approach that enhances the membrane selectivity of a prolific pore-forming peptide, melittin, based on experimental observations that the cationic polymer, e-polylysine, disrupts bacterial membranes with greater affinity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6efe981be56c06bd5e7bf076e078854c
https://doi.org/10.1021/acs.jmedchem.9b01846
https://doi.org/10.1021/acs.jmedchem.9b01846
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 50(7)
Futibatinib (FUT) is a potent inhibitor of fibroblast growth factor receptor (FGFR) 1-4 that is currently under clinical investigation for intrahepatic cholangiocarcinoma. Unlike its predecessors, FUT possesses an acrylamide warhead, which enables it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701a45e19d7c0d746de0046c7f2276f4
https://pubmed.ncbi.nlm.nih.gov/35512804
https://pubmed.ncbi.nlm.nih.gov/35512804
Autor:
Louis Tong, Lei Zhou, Lu Deng, Pat Lim, Siew Kwan Koh, Aihua Hou, Hla Myint Htoon, Qi-Ping Wei, Yan Gao
Publikováno v:
Clinical Ophthalmology (Auckland, N.Z.)
Louis Tong,1â 4 Lei Zhou,3â 5 Siew Kwan Koh,5 Yan Gao,5 Hla Myint Htoon,1,3 AiHua Hou,1,3 Lu Deng,6 Qi-Ping Wei,7 Pat Lim8 1Ocular Surface Research Group, Singapore Eye Research Institute, Singapore; 2Corneal and External Eye Disease Servic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a32b826db852392bc415c1a47d64604
https://pubmed.ncbi.nlm.nih.gov/34880595
https://pubmed.ncbi.nlm.nih.gov/34880595