Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Siew Heng Wong"'
Autor:
Kuen Kuen Lam, Yee Syuen Low, Michelle Lo, Michelle Wong, Choong Leong Tang, Emile Tan, Aik Yong Chok, Isaac Seow-En, Siew Heng Wong, Peh Yean Cheah
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Colorectal cancer (CRC) is the third highest incidence cancer and a leading cause of cancer mortality worldwide. To date, chemotherapeutic treatment of advanced CRC that has metastasized has a dismayed success rate of less than 30%. Further, most (80
Externí odkaz:
https://doaj.org/article/81b1cebe13f34c0d82560ad6fed3b289
Publikováno v:
Molecular Oncology, Vol 16, Iss 5, Pp 1171-1183 (2022)
KRAS is a gatekeeper gene in human colorectal tumorigenesis. KRAS is ‘undruggable’; hence, efforts have been diverted to inhibit downstream RAF/MEK/ERK and PI3K/Akt signaling. Nevertheless, none of these inhibitors has progressed to clinical use
Externí odkaz:
https://doaj.org/article/9a6cf8a0a2734ec799f79027954a5b05
Publikováno v:
Cells, Vol 12, Iss 4, p 631 (2023)
This review summarizes recent development in synthetic drugs and biologics targeting intracellular driver genes in epithelial cancers, focusing on KRAS, and provides a current perspective and potential leads for the field. Compared to biologics, smal
Externí odkaz:
https://doaj.org/article/29dd6a20dcea4f18bce2c56c4680cc38
Autor:
Peh Yean Cheah, Kuen Kuen Lam, Yee Syuen Low, Michelle Lo, Michelle Wong, Choong Leong Tang, Emile Tan, Aik Yong Chok, Issac Seow En, Siew Heng Wong
Publikováno v:
Cancer Research. 83:4119-4119
Worldwide, colorectal cancer (CRC) is the third highest incidence cancer and a leading cause of cancer mortality. Metastasis to distal organ is the major cause of cancer mortality. However, chemotherapeutic treatment of metastatic CRC has a dismayed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc1af2ecb308807d9de72978ab096c53
https://doi.org/10.1158/1538-7445.am2023-4119
https://doi.org/10.1158/1538-7445.am2023-4119
Publikováno v:
Cancer Research. 82:6192-6192
Colorectal cancer (CRC) is the third highest incident cancer worldwide and a major cause of cancer death. KRAS protein gain-of-function point mutations play major roles in colorectal tumorigenesis. However, direct inhibition of KRAS is challenging as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cb03878abd39d8db82750ce5f134f90
https://doi.org/10.1158/1538-7445.am2022-6192
https://doi.org/10.1158/1538-7445.am2022-6192
Autor:
Meng Teng Peh, Yulan Han, Deyu Tarika Cai, Seok Hui Wee, Siew Heng Wong, Yong Hou Sunny Ho, Kher Hsin Chiow
Publikováno v:
Molecular Membrane Biology. 28:90-102
Since being introduced globally as Aspirin in 1899, acetylsalicylic acid (ASA) has been widely used as an analgesic, immune-regulatory, anti-pyretic and anti-thrombotic drug. ASA and its metabolite, salicylate, were also reported to be able to modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5024e0dacc69442efaafc243693cac89
https://doi.org/10.3109/09687688.2010.525756
https://doi.org/10.3109/09687688.2010.525756
Autor:
Boon Heng Dennis Teo, Siew Heng Wong
Publikováno v:
Biochemical and Biophysical Research Communications. 400:673-678
Dendritic cells (DC) - the sentinels of the immune system - play an important role in the maintenance of tolerance and induction of immunity. However, in autoimmune diseases, DC initiate the diseases by presenting self antigens to autoreactive T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c9ea977e26bfcf1a09432e96539132
https://doi.org/10.1016/j.bbrc.2010.08.126
https://doi.org/10.1016/j.bbrc.2010.08.126
Autor:
Michelle Lo, Peh Yean Cheah, See Aik Tang, Siew Heng Wong, Yee Syuen Low, Choong Leong Tang, Alphaeus Ng
Publikováno v:
Cancer Research. 78:1147-1147
Colorectal Cancer (CRC) is the third leading cause of cancer death worldwide. Majority of mortality is attributable to metastasis to distal organs. Current treatment targeting the ERK/MAPK pathway used monoclonal anti-EGFR antibody after the first li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a083336b6c7ba3d64632bb53a8ca4df
https://doi.org/10.1158/1538-7445.am2018-1147
https://doi.org/10.1158/1538-7445.am2018-1147
Publikováno v:
British Journal of Pharmacology. 159:1497-1510
Background and purpose: Andrographolide is the active component of Andrographis paniculata, a plant used in both Indian and Chinese traditional medicine, and it has been demonstrated to induce apoptosis in different cancer cell lines. However, not mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1952a377617793c6b0da10b9eeeae11
https://doi.org/10.1111/j.1476-5381.2009.00627.x
https://doi.org/10.1111/j.1476-5381.2009.00627.x
Autor:
Zhang Bao, W.S. Fred Wong, Chang Cheng, Songlian Wu, Bernard P. Leung, Shou Ping Guan, D. Michael Kemeny, Siew Heng Wong
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 179:657-665
Persistent activation of nuclear factor (NF)-kappaB has been associated with the development of asthma. Andrographolide, the principal active component of the medicinal plant Andrographis paniculata, has been shown to inhibit NF-kappaB activity.We hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34ecdd0b5bc0a899ed3372fcf520474
https://doi.org/10.1164/rccm.200809-1516oc
https://doi.org/10.1164/rccm.200809-1516oc