Výsledky vyhledávání - "Siew E. Chua"

Akademický článek

Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naïve patients with schizophrenia.

Autor: Qiang Wang, Bo Xiang, Wei Deng, Junyao Wu, Mingli Li, Xiaohong Ma, Yingcheng Wang, Lijun Jiang, Grainne McAlonan, Siew E Chua, Pak C Sham, Xun Hu, Tao Li

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e75083 (2013)

Reduced Gray matter (GM) volume is a core feature of schizophrenia. Mapping genes that is associated with the heritable disease-related phenotypes may be conducive to elucidate the pathogenesis of schizophrenia. This study aims to identify the common

Externí odkaz: https://doaj.org/article/5a39b2c32e964c179093836c53a0acdf

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Quantitative susceptibility mapping as an indicator of subcortical and limbic iron abnormality in Parkinson's disease with dementia

Autor: Shu-Leong Ho, Henry K.F. Mak, Queenie Chan, Grainne M. McAlonan, Nailin Yao, Shirley Yin-Yu Pang, Darrell T.H. Li, Edward S. Hui, Siew E. Chua

Publikováno v: NeuroImage: Clinical, Vol 20, Iss, Pp 365-373 (2018)
Li, D T H, Hui, E S, Chan, Q, Yao, N, Chua, S E, McAlonan, G M, Pang, S Y Y, Ho, S L & Mak, H K F 2018, ' Quantitative susceptibility mapping as an indicator of subcortical and limbic iron abnormality in Parkinson's disease with dementia ', NeuroImage: Clinical . https://doi.org/10.1016/j.nicl.2018.07.028
NeuroImage : Clinical

Late stage Parkinson's disease (PD) patients were commonly observed with other non-motor comorbidities such as dementia and psychosis. While abnormal iron level in the substantia nigra was clinically accepted as a biomarker of PD, it was also suggest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5511f11915318e1ffa4dd6738c50f42a
https://doi.org/10.1016/j.nicl.2018.07.028

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Akademický článek

MRI study of minor physical anomaly in childhood autism implicates aberrant neurodevelopment in infancy.

Autor: Charlton Cheung, Grainne M McAlonan, Yee Y Fung, Germaine Fung, Kevin K Yu, Kin-Shing Tai, Pak C Sham, Siew E Chua

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e20246 (2011)

BackgroundMPAs (minor physical anomalies) frequently occur in neurodevelopmental disorders because both face and brain are derived from neuroectoderm in the first trimester. Conventionally, MPAs are measured by evaluation of external appearance. Usin

Externí odkaz: https://doaj.org/article/ef8d2cf52daa4446825dc25d39b76a2a

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Akademický článek

Prenatal immune challenge is an environmental risk factor for brain and behavior change relevant to schizophrenia: evidence from MRI in a mouse model.

Autor: Qi Li, Charlton Cheung, Ran Wei, Edward S Hui, Joram Feldon, Urs Meyer, Sookja Chung, Siew E Chua, Pak C Sham, Ed X Wu, Grainne M McAlonan

Publikováno v: PLoS ONE, Vol 4, Iss 7, p e6354 (2009)

OBJECTIVES: Maternal infection during pregnancy increases risk of severe neuropsychiatric disorders, including schizophrenia and autism, in the offspring. The most consistent brain structural abnormality in patients with schizophrenia is enlarged lat

Externí odkaz: https://doaj.org/article/0ad9c7ab55e24d6582cbea45648c7c93

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A single low dose of valproic acid in late prenatal life alters postnatal behavior and glutamic acid decarboxylase levels in the mouse

Autor: Siew E. Chua, Ran Wei, Pak C. Sham, Charlton Cheung, Jana Leung, Qi Li, Sylvia Lam, Xiaofan Zhang, Grainne M. McAlonan

Publikováno v: Wei, R, Li, Q, Lam, S, Leung, J, Cheung, C, Zhang, X, Sham, P C, Chua, S E & McAlonan, G M 2016, ' A Single Low Dose of Valproic Acid in Late Prenatal Life Alters Postnatal Behavior and Glutamic Acid Decarboxylase Levels in the Mouse ', Behavioural brain research . https://doi.org/10.1016/j.bbr.2016.08.006

RationaleRodents exposed to valproic acid (VPA) in prenatal life exhibit post-natal characteristics analogous to autism spectrum disorder (ASD). Many previous studies used relatively high doses of VPA during early pregnancy, potentially confounding i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6e563f01f05460e33bd4104563442c
https://doi.org/10.1016/j.bbr.2016.08.006

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Tspyl2 Loss-of-Function Causes Neurodevelopmental Brain and Behavior Abnormalities in Mice

Autor: Siu Yuen Chan, Grainne M. McAlonan, Abby Y. Ding, Qi Li, Ed X. Wu, Tomy C. K. Hui, Kwun Kk Wong, Yu On Leung, Pak C. Sham, Ran Wei, Siew E. Chua, Charlton Cheung

Publikováno v: Behavior Genetics
Li, Q, Chan, S Y, Wong, K K, Wei, R, Leung, Y O, Ding, A Y, Hui, T C K, Cheung, C, Chua, S E, Sham, P C, Wu, E X & McAlonan, G M 2016, ' Tspyl2 Loss-of-Function Causes Neurodevelopmental Brain and Behavior Abnormalities in Mice ', Behavior Genetics, pp. 1-9 . https://doi.org/10.1007/s10519-015-9777-8

Testis specific protein, Y-encoded-like 2 (TSPYL2) regulates the expression of genes encoding glutamate receptors. Glutamate pathology is implicated in neurodevelopmental conditions such as autism spectrum disorder, attention deficit hyperactivity di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77830c5c6bad9bb32aee07162489594b
http://europepmc.org/articles/PMC4886156

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Multimodal MRI of the hippocampus in Parkinson’s disease with visual hallucinations

Autor: Nailin Yao, Charlton Cheung, Kevin Yu, Shu-Leong Ho, Henry K.F. Mak, Siew E. Chua, Shirley Yin-Yu Pang, Richard Shek-kwan Chang, John Suckling, Kui Kai Lau, Grainne M. McAlonan

Publikováno v: Yao, N, Cheung, C, Pang, S, Shek-Kwan Chang, R, Lau, K K, Suckling, J, Yu, K, Ka-Fung Mak, H, Chua, S E, Ho, S-L & McAlonan, G M 2014, ' Multimodal MRI of the hippocampus in Parkinson's disease with visual hallucinations ', Brain structure & function, vol. 221, pp. 287–300 . https://doi.org/10.1007/s00429-014-0907-5
Brain Structure & Function

Visual hallucinations carry poor prognosis in Parkinson’s disease. Here we tested the hypothesis that the hippocampus and visuospatial memory impairment play a central role in the pathology of PD with visual hallucinations. Multimodal magnetic reso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a1d9adb2235d1e30b06f8dc3871e1a
https://doi.org/10.1007/s00429-014-0907-5

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Extensive brain structural network abnormality in first-episode treatment-naive patients with schizophrenia: morphometrical and covariation study

Autor: P. C. Sham, Wei Deng, Qiyong Gong, Qiang Wang, Zhuangfei Chen, Siew E. Chua, Philip McGuire, Y. Wang, Min Li, X. Ma, Chaohua Huang, Tao Li, Lijun Jiang, Zong-Ling He, Grainne M. McAlonan, David A. Collier

Publikováno v: Psychological Medicine. 44:2489-2501

BackgroundAlterations in gray matter (GM) are commonly observed in schizophrenia. Accumulating studies suggest that the brain changes associated with schizophrenia are distributed rather than focal, involving interconnected networks of areas as oppos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ea5291b907f0d744c67e3a958f2999
https://doi.org/10.1017/s003329171300319x

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White-matter microstructure in previously drug-naive patients with schizophrenia after 6 weeks of treatment

Autor: Qiang Wang, Monica X. Li, Siew E. Chua, Grainne M. McAlonan, Y. Wang, Wei Deng, P. C. Sham, David A. Collier, Tao Li, Ching-Lung Cheung, Lijun Jiang, Qiyong Gong, Chaohua Huang, X. Ma

Publikováno v: Psychological Medicine. 43:2301-2309

BackgroundIt is not clear whether the progressive changes in brain microstructural deficits documented in previous longitudinal magnetic resonance imaging (MRI) studies might be due to the disease process or to other factors such as medication. It is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22065df54d4138f024351fa4f0a9ed49
https://doi.org/10.1017/s0033291713000238

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Fronto-parietal white matter microstructural deficits are linked to performance IQ in a first-episode schizophrenia Han Chinese sample

Autor: Wei Deng, David A. Collier, Y. Wang, X. Ma, Qiang Wang, Siew E. Chua, Lijun Jiang, Ching-Lung Cheung, P. C. Sham, Grainne M. McAlonan, Chaohua Huang, Min Li, Qiyong Gong, Tao Li

Publikováno v: Psychological Medicine. 43:2047-2056

BackgroundEvidence shows that cognitive deficits and white matter (WM) dysconnectivity can independently be associated with clinical manifestations in schizophrenia. It is important to explore this triadic relationship in order to investigate whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116bb0d2ee7390e6d6bda5ebd8797885
https://doi.org/10.1017/s0033291712002905

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