Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Siew Cheng Wong"'
Autor:
Je Lin Sieow, Hweixian Leong Penny, Sin Yee Gun, Ling Qiao Tan, Kaibo Duan, Joe Poh Sheng Yeong, Angela Pang, Diana Lim, Han Chong Toh, Tony Kiat Hon Lim, Edgar Engleman, Olaf Rotzschke, Lai Guan Ng, Jinmiao Chen, Suet Mien Tan, Siew Cheng Wong
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 753 (2023)
Large numbers of neutrophils infiltrate tumors and comprise a notable component of the inflammatory tumor microenvironment. While it is established that tumor cells exhibit the Warburg effect for energy production, the contribution of the neutrophil
Externí odkaz:
https://doaj.org/article/457e65b307ea49d9be029fd9c61d0cbb
Autor:
Jorming Goh, Peter Hofmann, Ning Hong Aw, Poh Ling Tan, Gerhard Tschakert, Alexander Mueller, Siew Cheng Wong, Frankie Tan, Linda Seo Hwee Gan
Publikováno v:
Translational Medicine Communications, Vol 5, Iss 1, Pp 1-15 (2020)
Abstract Background Intense exercise is a systemic stressor associated with the release of “danger” molecules – alarmins, by damaged or dying cells into systemic circulation to evoke a sterile inflammatory response. Compared with research in cl
Externí odkaz:
https://doaj.org/article/42c49f74559b4656a1463c7d9ae9dd80
Autor:
Hweixian Leong Penny, Je Lin Sieow, Sin Yee Gun, Mai Chan Lau, Bernett Lee, Jasmine Tan, Cindy Phua, Florida Toh, Yvonne Nga, Wei Hseun Yeap, Baptiste Janela, Dilip Kumar, Hao Chen, Joe Yeong, Justin A. Kenkel, Angela Pang, Diana Lim, Han Chong Toh, Tony Lim Kiat Hon, Christopher I. Johnson, Hanif Javanmard Khameneh, Alessandra Mortellaro, Edgar G. Engleman, Olaf Rotzschke, Florent Ginhoux, Jean-Pierre Abastado, Jinmiao Chen, Siew Cheng Wong
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6350 (2021)
Inflammation in the tumor microenvironment has been shown to promote disease progression in pancreatic ductal adenocarcinoma (PDAC); however, the role of macrophage metabolism in promoting inflammation is unclear. Using an orthotopic mouse model of P
Externí odkaz:
https://doaj.org/article/722da39515a74b9cb8cb1b700827bb3e
Publikováno v:
Redox Biology, Vol 25, Iss , Pp - (2019)
Recent years have seen a renaissance in the research linking inflammation and cancer with immune cells playing a central role in smouldering inflammation in the tumor microenvironment. Diverse immune cell types infiltrate the tumor microenvironment,
Externí odkaz:
https://doaj.org/article/ad97115fc82d4e8282a3f81eb51395ec
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Immune cells are one of the most versatile cell types, as they can tailor their metabolic activity according to their required function. In response to diverse environmental cues, immune cells undergo metabolic reprogramming to support their differen
Externí odkaz:
https://doaj.org/article/b8bbcec2b37c4f7daabadfa4e9eaaaf6
Autor:
Sharon Wei Ling Lee, Giulia Adriani, Erica Ceccarello, Andrea Pavesi, Anthony Tanoto Tan, Antonio Bertoletti, Roger Dale Kamm, Siew Cheng Wong
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Externí odkaz:
https://doaj.org/article/2986de78cbcb4a47ae8e0da0f6ffa32b
Autor:
Sharon Wei Ling Lee, Giulia Adriani, Erica Ceccarello, Andrea Pavesi, Anthony Tanoto Tan, Antonio Bertoletti, Roger Dale Kamm, Siew Cheng Wong
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
In the hepatitis B virus (HBV)-related hepatocellular carcinoma tumor microenvironment (TME), monocytes reportedly impede natural T cell functions via PD-L1/PD-1 signaling. However, it remains unclear if T cell receptor-redirected T cells (TCR T cell
Externí odkaz:
https://doaj.org/article/df8b339b4d5343a88beaca912011bf90
Autor:
Nishanth Venugopal Menon, Hui Min Tay, Kuin Tian Pang, Rinkoo Dalan, Siew Cheng Wong, Xiaomeng Wang, King Ho Holden Li, Han Wei Hou
Publikováno v:
APL Bioengineering, Vol 2, Iss 1, Pp 016103-016103-12 (2018)
Atherosclerosis, a chronic inflammatory disorder characterized by endothelial dysfunction and blood vessel narrowing, is the leading cause of cardiovascular diseases including heart attack and stroke. Herein, we present a novel tunable microfluidic a
Externí odkaz:
https://doaj.org/article/ebec506768f04612a47a84541caf496f
Autor:
Tsung Wen Chong, June Jingyi Tai, Shazib Pervaiz, Siew Cheng Wong, Gregory Lucien Bellot, Binbin Wang, Herbert Schwarz, Kartini Iskandar, Fera Yiqian Goh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Sepsis is a potentially fatal condition triggered by systemic inflammatory response to infection. Due to the heightened immune reactivity and multi-organ pathology, treatment options are limited and several clinical trials have not produced the desir
Publikováno v:
The FASEB Journal. 34:11133-11142
Vitamin D deficiency is a major public health problem worldwide, linked to several chronic diseases including cardiovascular diseases. While immunomodulatory effects of vitamin D on monocytes have been reported in cardiovascular and metabolic disease