Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Siew Cheng Phua"'
Growth and site-specific organization of micron-scale biomolecular devices on living mammalian cells
Autor:
Sisi Jia, Siew Cheng Phua, Yuta Nihongaki, Yizeng Li, Michael Pacella, Yi Li, Abdul M. Mohammed, Sean Sun, Takanari Inoue, Rebecca Schulman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Mesoscale molecular assemblies on the cell surface integrate information and amplify signals. Here the authors integrate DNA nanotubes in a controlled manner with mammalian cells to act as sheer stress meters.
Externí odkaz:
https://doaj.org/article/69fc8bc374494994b279afe01cbb6a3f
Growth and site-specific organization of micron-scale biomolecular devices on living mammalian cells
Autor:
Takanari Inoue, Siew Cheng Phua, Michael S. Pacella, Rebecca Schulman, Sisi Jia, Yi Li, Sean X. Sun, Yizeng Li, Abdul M. Mohammed, Yuta Nihongaki
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Mesoscale molecular assemblies on the cell surface, such as cilia and filopodia, integrate information, control transport and amplify signals. Synthetic devices mimicking these structures could sensitively monitor these cellular functions and direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c98ed3fe2f7af79c2adcd3758f1d40
http://arxiv.org/abs/2101.07764
http://arxiv.org/abs/2101.07764
Publikováno v:
Current opinion in cell biology. 50
The primary cilium is a cell surface projection from plasma membrane which transduces external stimuli to diverse signaling pathways. To function as an independent signaling organelle, the molecular composition of the ciliary membrane has to be disti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b04db1984750e47440549c24202d50
https://pubmed.ncbi.nlm.nih.gov/29477020
https://pubmed.ncbi.nlm.nih.gov/29477020
Autor:
Siew Cheng Phua1 phua0022@e.ntu.edu.sg, Yu Lin Tan1 tanyulin95@hotmail.com, Maun Yeng Kok, Alison1,2, Senol, Esra1,2, Jin Hui Chiam, Christine1, Chun-Yao Lee1, Yanmin Peng1,3, Lim, Auriel Theodora Jacobea1, Mohammad, Hasan1, Jing-Xuan Lim1, Yu Fu1,2,4 fu_yu@imcb.a-star.edu.sg
Publikováno v:
Science Advances. 5/5/2021, Vol. 7 Issue 19, p1-14. 14p.
Publikováno v:
Current Opinion in Chemical Biology. 17:663-671
Diffusion barriers are universal solutions for cells to achieve distinct organizations, compositions, and activities within a limited space. The influence of diffusion barriers on the spatiotemporal dynamics of signaling molecules often determines ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e940d71393a542b3d6941febf9723f
https://doi.org/10.1016/j.cbpa.2013.04.027
https://doi.org/10.1016/j.cbpa.2013.04.027
Autor:
Andre Levchenko, Benjamin Lin, John Jiao, Rajat Rohatgi, Pawel Niewiadomski, Takanari Inoue, Hideki Nakamura, Siew Cheng Phua, Yu Chun Lin, Takafumi Inoue
Publikováno v:
Nature Chemical Biology. 9:437-443
Primary cilia function as specialized compartments for signal transduction. The stereotyped structure and signaling function of cilia inextricably depend on the selective segregation of molecules in cilia. However, the fundamental principles governin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5e737d9c5f7cfa5f9dd7eddbbb8734
https://doi.org/10.1038/nchembio.1252
https://doi.org/10.1038/nchembio.1252
Autor:
Jeremy F. Reiter, Shuhei Chiba, Elle C. Roberson, Ganesh V. Pusapati, Siew Cheng Phua, Emily Y. Su, Takanari Inoue, Mitsutoshi Setou, Masako Suzuki, Koji Ikegami, Rajat Rohatgi, Stéphane Schurmans
Publikováno v:
Cell. 168(1-2)
The life cycle of a primary cilium begins in quiescence and ends prior to mitosis. In quiescent cells, the primary cilium insulates itself from contiguous dynamic membrane processes on the cell surface to function as a stable signaling apparatus. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f543098f0ce3e5bca64641d42f269f2
https://pubmed.ncbi.nlm.nih.gov/31251914
https://pubmed.ncbi.nlm.nih.gov/31251914
Publikováno v:
ACS Chemical Biology. 7:1950-1955
Chemically-inducible rapid manipulation of small GTPase activity has proven a powerful approach to dissect complex spatio-temporal signaling of these molecular switches. However, overexpression of these synthetic molecular probes freely in the cytoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0252bfd25ff09f491c48f6508f42e4
https://doi.org/10.1021/cb300280k
https://doi.org/10.1021/cb300280k
Publikováno v:
Kidney International. 73(10):1187-1192
Organs such as the lung and the kidney are composed of epithelial and endothelial tubule-forming networks. To engineer such organs, it would be desirable to control the shape, spatial orientation and interconnectedness of the forming tubules. To stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810ee4947ed9eb44324ccfeb436409dd
Autor:
Galo Garcia, Takanari Inoue, Stéphane Schurmans, Jeremy F. Reiter, Siew Cheng Phua, Monika Abedin, Elle C. Roberson, Francesc R. Garcia-Gonzalo
Publikováno v:
Developmental cell, vol 34, iss 4
SummaryPrimary cilia interpret vertebrate Hedgehog (Hh) signals. Why cilia are essential for signaling is unclear. One possibility is that some forms of signaling require a distinct membrane lipid composition, found at cilia. We found that the ciliar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558c9ecdd1133bfa861f74eb5141fa9c
https://pubmed.ncbi.nlm.nih.gov/26373264
https://pubmed.ncbi.nlm.nih.gov/26373264