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Crystal structures of amyloidogenic segments of human transthyretin.

Autor: Saelices L; Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, Box 951570, UCLA, Howard Hughes Medical Institute, UCLA-DOE Institute, Los Angeles, California, 90095-1570., Sievers SA; Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, Box 951570, UCLA, Howard Hughes Medical Institute, UCLA-DOE Institute, Los Angeles, California, 90095-1570., Sawaya MR; Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, Box 951570, UCLA, Howard Hughes Medical Institute, UCLA-DOE Institute, Los Angeles, California, 90095-1570., Eisenberg DS; Departments of Biological Chemistry and Chemistry and Biochemistry, Molecular Biology Institute, Box 951570, UCLA, Howard Hughes Medical Institute, UCLA-DOE Institute, Los Angeles, California, 90095-1570.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2018 Jul; Vol. 27 (7), pp. 1295-1303. Date of Electronic Publication: 2018 Jun 13.

Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.

Autor: Freund NT; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Wang H; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Scharf L; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Nogueira L; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Horwitz JA; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Bar-On Y; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Golijanin J; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Sievers SA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Sok D; Department of Immunology and Microbial Science, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, and International AIDS Vaccine Initiative Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Cai H; Department of Chemistry and Biochemistry, University of Maryland, 8051 Regents Drive, College Park, MD 20742, USA., Cesar Lorenzi JC; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Halper-Stromberg A; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Toth I; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02129, USA., Piechocka-Trocha A; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02129, USA., Gristick HB; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., van Gils MJ; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., Sanders RW; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., Wang LX; Department of Chemistry and Biochemistry, University of Maryland, 8051 Regents Drive, College Park, MD 20742, USA., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Burton DR; Department of Immunology and Microbial Science, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, and International AIDS Vaccine Initiative Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02129, USA., Gazumyan A; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Walker BD; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02129, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., West AP Jr; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Nussenzweig MC; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA. nussen@rockefeller.edu.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2017 Jan 18; Vol. 9 (373).

A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.

Autor: Freund NT; Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America., Horwitz JA; Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America., Nogueira L; Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America., Sievers SA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America., Scharf L; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America., Scheid JF; Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America., Gazumyan A; Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America., Liu C; Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America., Velinzon K; Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America., Goldenthal A; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America., Sanders RW; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Moore JP; Department of Microbiology and Immunology, Weill Medical College, Cornell University, New York, New York, United States of America., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America., Walker BD; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America., Klein F; First Department of Internal Medicine, University Hospital of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany., Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2015 Oct 30; Vol. 11 (10), pp. e1005238. Date of Electronic Publication: 2015 Oct 30 (Print Publication: 2015).

Structure-based design of functional amyloid materials.

Autor: Li D; UCLA-DOE Institute, and Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095, United States., Jones EM, Sawaya MR, Furukawa H, Luo F, Ivanova M, Sievers SA, Wang W, Yaghi OM, Liu C, Eisenberg DS

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2014 Dec 31; Vol. 136 (52), pp. 18044-51. Date of Electronic Publication: 2014 Dec 19.