Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Sietse Q. Nagelkerke"'
Autor:
Denise H. J. Habets, Salwan Al-Nasiry, Sietse Q. Nagelkerke, Christina E. M. Voorter, Marc E. A. Spaanderman, Taco W. Kuijpers, Lotte Wieten
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Natural Killer (NK) cells have been implicated in recurrent pregnancy loss (RPL). The p.Val176Phe (or Val158Phe) Single Nucleotide Polymorphism (SNP) in the FCGR3A gene encoding the FcγRIIIA or CD16a receptor has been associated with an enh
Externí odkaz:
https://doaj.org/article/46efa02860574504b8b3000d88c02274
Autor:
Stejara A. Netea, Giske Biesbroek, Diana van Stijn, Hanna Ijspeert, Caspar I. van der Made, Machiel H. Jansen, Judy Geissler, J.M. (Merlijn) van den Berg, Martijn van der Kuip, Mariken P. Gruppen, Dieneke Schonenberg-Meinema, Berber Kapitein, A.M. (Marceline) Tutu van Furth, Sietse Q. Nagelkerke, Dasja Pajkrt, Frans B. Plötz, M.E.J. (Lisette) den Boer, Gijs W. Landman, Marlies A. van Houten, Ines Goetschalckx, Erik J.M. Toonen, Frank L. van de Veerdonk, Irene M. Kuipers, Willem A. Dik, Taco W. Kuijpers, T. Hendriks, M.K. Felderhof, N.M. Weggelaar, L. Filippini, L. Rozendaal, M. Groeneweg, R. Nuboer, M. Bruijn, K.M. Dolman, J.G. Noordzij, J.P. de Winter, A.M. Vlieger, F.B. Plötz, L.C. Delemarre
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104736- (2023)
Summary: Background: Children with SARS-CoV-2 related Multisystem Inflammatory Syndrome in Children (MIS-C) often present with clinical features that resemble Kawasaki disease (KD). Disease severity in adult COVID-19 is associated to the presence of
Externí odkaz:
https://doaj.org/article/93828e5e066e4179b2b6ff7905fc558a
Autor:
A. Robin Temming, Matthias Tammes Buirs, Arthur E. H. Bentlage, Louise W. Treffers, Hannah Feringa, Steven W. de Taeye, Taco W. Kuijpers, Sietse Q. Nagelkerke, Giso Brasser, Juk Yee Mok, Wim J. E. van Esch, Timo K. van den Berg, Theo Rispens, C. Ellen van der Schoot, Gestur Vidarsson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Antibody-mediated blood disorders ensue after auto- or alloimmunization against blood cell antigens, resulting in cytopenia. Although the mechanisms of cell destruction are the same as in immunotherapies targeting tumor cells, many factors are still
Externí odkaz:
https://doaj.org/article/a051437a3dee48c7afce6b02bcb366cb
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Fc-gamma receptors (FcγR) are the cellular receptors for Immunoglobulin G (IgG). Upon binding of complexed IgG, FcγRs can trigger various cellular immune effector functions, thereby linking the adaptive and innate immune systems. In humans, six cla
Externí odkaz:
https://doaj.org/article/ff116c11ecb041eba24932beb20576d6
Autor:
Sietse Q. Nagelkerke, Carline E. Tacke, Willemijn B. Breunis, Michael W. T. Tanck, Judy Geissler, Eileen Png, Long T. Hoang, Joris van der Heijden, Ahmad N. M. Naim, Rae S. M. Yeung, Michael L. Levin, Victoria J. Wright, David P. Burgner, Anne-Louise Ponsonby, Justine A. Ellis, Rolando Cimaz, Chisato Shimizu, Jane C. Burns, Karin Fijnvandraat, C. Ellen van der Schoot, Timo K. van den Berg, Martin de Boer, Sonia Davila, Martin L. Hibberd, Taco W. Kuijpers, The International Kawasaki Disease Genetics Consortium, Nagib Dahdah, Isabelle Kone-Paut
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The human Fc-gamma receptors (FcγRs) link adaptive and innate immunity by binding immunoglobulin G (IgG). All human low-affinity FcγRs are encoded by the FCGR2/3 locus containing functional single nucleotide polymorphisms (SNPs) and gene copy numbe
Externí odkaz:
https://doaj.org/article/d7250016b76748308206a393860e611b
Autor:
Louise W. Treffers, Michel van Houdt, Christine W. Bruggeman, Marieke H. Heineke, Xi Wen Zhao, Joris van der Heijden, Sietse Q. Nagelkerke, Paul J. J. H. Verkuijlen, Judy Geissler, Suzanne Lissenberg-Thunnissen, Thomas Valerius, Matthias Peipp, Katka Franke, Robin van Bruggen, Taco W. Kuijpers, Marjolein van Egmond, Gestur Vidarsson, Hanke L. Matlung, Timo K. van den Berg
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
The function of the low-affinity IgG-receptor FcγRIIIb (CD16b), which is uniquely and abundantly expressed on human granulocytes, is not clear. Unlike the other Fcγ receptors (FcγR), it is a glycophosphatidyl inositol (GPI) -anchored molecule and
Externí odkaz:
https://doaj.org/article/4f7effa6b2a44b6cb973aba88e5a5277
Autor:
Peter Boross, Jeanette H.W. Leusen, Thomas Valerius, Stefan Lohse, Gerard Rouwendal, Ruud Ubink, István Németh, Sietse Q. Nagelkerke, M. Alejandra Beltrán Buitrago, J.H. Marco Jansen, Saskia Meyer, Geert van Tetering, Laura A.P.M. Meulenbroek, Maaike Nederend, Toine ten Broeke, Arianne M. Brandsma
Supplementary figure legends and Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c48370f8dc02403421b6b6be685237d
https://doi.org/10.1158/2326-6066.22537123.v1
https://doi.org/10.1158/2326-6066.22537123.v1
Autor:
Peter Boross, Jeanette H.W. Leusen, Thomas Valerius, Stefan Lohse, Gerard Rouwendal, Ruud Ubink, István Németh, Sietse Q. Nagelkerke, M. Alejandra Beltrán Buitrago, J.H. Marco Jansen, Saskia Meyer, Geert van Tetering, Laura A.P.M. Meulenbroek, Maaike Nederend, Toine ten Broeke, Arianne M. Brandsma
Leukocyte-mediated cytotoxicity with IgG and IgA. 4 hour 51Cr-release assay by leukocytes using (A) A431 cells and (B) SK-BR-3 cells and 1 µg/ml mAb. Representative results of two (A) and four (B) experiments performed with different donors (Mean {p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba84ac6b42b6ec6082a4154802e930f
https://doi.org/10.1158/2326-6066.22537138.v1
https://doi.org/10.1158/2326-6066.22537138.v1
Autor:
Peter Boross, Jeanette H.W. Leusen, Thomas Valerius, Stefan Lohse, Gerard Rouwendal, Ruud Ubink, István Németh, Sietse Q. Nagelkerke, M. Alejandra Beltrán Buitrago, J.H. Marco Jansen, Saskia Meyer, Geert van Tetering, Laura A.P.M. Meulenbroek, Maaike Nederend, Toine ten Broeke, Arianne M. Brandsma
Efficacy of anticancer monoclonal antibodies (mAb) is limited by the exhaustion of effector mechanisms. IgG mAbs mediate cellular effector functions through FcγRs expressed on effector cells. IgA mAbs can also induce efficient tumor killing both in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c999899ed314911ffba086419467c90
https://doi.org/10.1158/2326-6066.c.6548326.v1
https://doi.org/10.1158/2326-6066.c.6548326.v1
Autor:
Peter Boross, Jeanette H.W. Leusen, Thomas Valerius, Stefan Lohse, Gerard Rouwendal, Ruud Ubink, István Németh, Sietse Q. Nagelkerke, M. Alejandra Beltrán Buitrago, J.H. Marco Jansen, Saskia Meyer, Geert van Tetering, Laura A.P.M. Meulenbroek, Maaike Nederend, Toine ten Broeke, Arianne M. Brandsma
PMN-mediated cytotoxicity is not increased by the combination of IgG and IgA against two targets. (A) Pooled data (8 donors) from ADCC assays were performed using purified PMNs isolated by Ficoll/Histopaque separation and A431-HER2 target cells eithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9e1bb9e3deea67e57db5a3b039e313
https://doi.org/10.1158/2326-6066.22537126.v1
https://doi.org/10.1158/2326-6066.22537126.v1