Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sierra McDonald"'
Autor:
Alexander T. Sougiannis, Reilly T. Enos, Brandon N. VanderVeen, Kandy T. Velazquez, Brittany Kelly, Sierra McDonald, William Cotham, Ioulia Chatzistamou, Mitzi Nagarkatti, Daping Fan, E. Angela Murphy
Publikováno v:
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background Emodin, a natural anthraquinone, has shown potential as an effective therapeutic agent in the treatment of many diseases including cancer. However, its clinical development is hindered by uncertainties surrounding its potential to
Externí odkaz:
https://doaj.org/article/a0f2c29434f2447cacbf5d5e9e2dad81
Autor:
In-Young Jung, Vivek Narayan, Sierra McDonald, Andrew J. Rech, Robert Bartoszek, Gwanui Hong, Megan M. Davis, Jun Xu, Alina C. Boesteanu, Julie S. Barber-Rotenberg, Gabriela Plesa, Simon F. Lacey, Julie K. Jadlowsky, Donald L. Siegel, Dana M. Hammill, Park F. Cho-Park, Shelley L. Berger, Naomi B. Haas, Joseph A. Fraietta
Publikováno v:
Science Translational Medicine. 14
Chimeric antigen receptor (CAR) T cells have not induced meaningful clinical responses in solid tumors. Loss of T cell stemness, poor expansion capacity, and exhaustion during prolonged tumor antigen exposure are major causes of CAR T cell therapeuti
Autor:
Michael T. Werner, Jennifer E. Wu, Wei Xu, Patrick Yan, Giorgos C. Karakousis, Bertram Bengsch, Kunal P. Patel, Alexander C. Huang, Jonathan Kaye, Shelley L. Berger, Sasikanth Manne, Tara C. Mitchell, Omar Khan, Ryan P. Staupe, John Attanasio, Sierra McDonald, Xiaowei Xu, Sangeeth M. George, Shin Foong Ngiow, Josephine R. Giles, Ravi K. Amaravadi, Lynn M. Schuchter, E. John Wherry, Katherine A. Alexander, Greg Donahue
Publikováno v:
Nature
Exhausted CD8+ T (Tex) cells in chronic infections and cancer have limited effector function, high co-expression of inhibitory receptors and extensive transcriptional changes compared with effector (Teff) or memory (Tmem) CD8+ T cells. Tex cells are
Autor:
E. Angela Murphy, Ioulia Chatzistamou, Brandon N. VanderVeen, Sierra McDonald, Taryn L. Cranford, Jackie E. Bader, Daping Fan, Alexander T Sougiannis, Reilly T. Enos, Kandy T. Velázquez
Publikováno v:
J Appl Physiol (1985)
Weight fluctuations are common among individuals with obesity and are associated with increased morbidity. We examined adipose tissue immune and inflammatory markers in mice following weight loss and partial weight regain. Male C57BL/6 mice were rand
Autor:
Daping Fan, Alexander T Sougiannis, Brandon N. VanderVeen, William E. Cotham, Kandy T. Velázquez, Ioulia Chatzistamou, Mitzi Nagarkatti, E. Angela Murphy, Sierra McDonald, Brittany Kelly, Reilly T. Enos
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-12 (2021)
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-12 (2021)
Background Emodin, a natural anthraquinone, has shown potential as an effective therapeutic agent in the treatment of many diseases including cancer. However, its clinical development is hindered by uncertainties surrounding its potential toxicity. T
Autor:
Reilly T. Enos, Ioulia Chatzistamou, Daping Fan, Kandy T. Velázquez, E. Angela Murphy, Taryn L. Cranford, Brandon N. VanderVeen, Sierra McDonald, Alexander T Sougiannis
Publikováno v:
The FASEB Journal. 34:1-1
Publikováno v:
Cancer Immunology Research. 7:A197-A197
The protective capacity of the adaptive immune system relies on efficient and coordinated transitions between cellular fates. Following initial activation by specific antigen, naïve CD8+ T-cells proliferate extensively and undergo a highly orchestra
Publikováno v:
The Journal of Immunology. 198:124.2-124.2
It has previously been demonstrated that chromatin decondensation is required for αβ T cell proliferation. B cells, γδ T cells, and Natural Killer cells share the same lineage as αβ T cells, originating from hematopoietic stem cells and a commo