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Akademický článek

Realizing the Potential of Vascular Targeted Therapy: The Rationale for Combining Vascular Disrupting Agents and Anti-Angiogenic Agents to Treat Cancer.

Autor: Siemann, D. W.¹ (AUTHOR) siemadw@ufl.edu, Chaplin, D. J.² (AUTHOR), Horsman, M. R.³ (AUTHOR)

Publikováno v: Cancer Investigation. 2017, Vol. 35 Issue 8, p519-534. 16p.

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Differentiation and Definition of Vascular-Targeted Therapies

Autor: Siemann, D. W., Bibby, M. C., Dark, G. G., Dicker, A. P., Eskens, F. A. L. M., Michael Horsman, Marmé, D., Lorusso, P. M.

Publikováno v: Scopus-Elsevier
Siemann, D W, Bibby, M C, Dark, G G, Dicker, A P, Eskens, F A L M, Horsman, M R, Marmé, D & LoRusso, P M 2005, ' Differentiation and definition of vascular-targeted therapies ', Clinical Cancer Research, vol. 11, no. 2 Pt 1, pp. 416-420 . < http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15701823&query_hl=53&itool=pubmed_docsum >
Clinical Cancer Research, 11, 416-420. American Association for Cancer Research Inc.

The therapeutic potential of targeting the tumor vascular supply is now widely recognized. Intense research and development activity has resulted in a variety of investigational agents, a number of which are currently in clinical development. As thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef411d0252696c3e487e92ae9bd8475
https://doi.org/10.1158/1078-0432.416.11.2

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Nicotinamide as a radiosensitizer in tumours and normal tissues: the importance of drug dose and timing

Autor: Horsman, M R, Siemann, D W, Chaplin, D J, Overgaard, J

Publikováno v: Horsman, M R, Siemann, D W, Chaplin, D J & Overgaard, J 1997, ' Nicotinamide as a radiosensitizer in tumours and normal tissues: the importance of drug dose and timing ', Radiotherapy & Oncology, vol. 45, no. 2, pp. 167-74 .

Nicotinamide is a radiation sensitizer currently undergoing clinical testing. This was an experimental study to determine the importance of drug dose and time interval between drug administration and irradiation for radiosensitization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::9f2a21920ac32539134511ca0c940c20
https://pure.au.dk/portal/da/publications/nicotinamide-as-a-radiosensitizer-in-tumours-and-normal-tissues-the-importance-of-drug-dose-and-timing(de432b66-6f37-4c55-a5d3-65a72b84a42f).html

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Reducing acute and chronic hypoxia in tumours by combining nicotinamide with carbogen breathing

Autor: Horsman, Michael Robert, Nordsmark, Marianne, Khalil, Azza Ahmed, Hill, S A, Chaplin, D J, Siemann, D W, Overgaard, Jens

Publikováno v: Horsman, M R, Nordsmark, M, Khalil, A A, Hill, S A, Chaplin, D J, Siemann, D W & Overgaard, J 1994, ' Reducing acute and chronic hypoxia in tumours by combining nicotinamide with carbogen breathing ', Acta Oncologica, vol. 33, no. 4, pp. 371-6 .

The ability of nicotinamide and carbogen breathing to improve the radiation response of a C3H mammary carcinoma by reducing both acute and chronic hypoxia was investigated. Using a tumour growth delay assay the response of 200 mm3 foot tumours to loc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::d9ead6241e2cf39b9c4428480bf08331
https://pure.au.dk/portal/da/publications/reducing-acute-and-chronic-hypoxia-in-tumours-by-combining-nicotinamide-with-carbogen-breathing(580a0092-a8ef-4c31-ad98-4cc12b1ca34d).html

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