Realizing the Potential of Vascular Targeted Therapy: The Rationale for Combining Vascular Disrupting Agents and Anti-Angiogenic Agents to Treat Cancer.

Autor: Siemann, D. W.¹ (AUTHOR) siemadw@ufl.edu, Chaplin, D. J.² (AUTHOR), Horsman, M. R.³ (AUTHOR)

Publikováno v: Cancer Investigation. 2017, Vol. 35 Issue 8, p519-534. 16p.

Cysteine protease I29 propeptide from Calotropis procera R. Br. As a potent cathepsin L inhibitor and its suppressive activity in breast cancer metastasis.

Autor: Kwon YJ; Department of Pharmacology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.; Department of Cosmetic Science, Kyungsung University, Busan, 48434, Republic of Korea., Lee J; Center for Agricultural Microorganism and Enzyme, Seoul National University, Seoul, 08826, Republic of Korea.; Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, 08826, Republic of Korea., Seo EB; Department of Pharmacology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.; Biomedical Science Project (BK21PLUS), Seoul National University College of Medicine, Seoul, 03080, Republic of Korea., Lee J; Department of Agricultural Biotechnology, Seoul National University College of Agricultural and Life Sciences, Seoul, 08826, Republic of Korea., Park J; Department of Agricultural Biotechnology, Seoul National University College of Agricultural and Life Sciences, Seoul, 08826, Republic of Korea., Kim SK; Department of Pharmacology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea., Yu H; Major of Food Science and Biotechnology, Division of Bio-Convergence, Kyonggi University, Suwon, 16227, Republic of Korea., Ye SK; Department of Pharmacology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. sangkyu@snu.ac.kr.; Biomedical Science Project (BK21PLUS), Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. sangkyu@snu.ac.kr.; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. sangkyu@snu.ac.kr.; Neuro-Immune Information Storage Network Research Center, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. sangkyu@snu.ac.kr.; Wide River Institute of Immunology, Seoul National University, Hongcheon, 25159, Republic of Korea. sangkyu@snu.ac.kr., Chang PS; Center for Agricultural Microorganism and Enzyme, Seoul National University, Seoul, 08826, Republic of Korea. pschang@snu.ac.kr.; Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, 08826, Republic of Korea. pschang@snu.ac.kr.; Department of Agricultural Biotechnology, Seoul National University College of Agricultural and Life Sciences, Seoul, 08826, Republic of Korea. pschang@snu.ac.kr.; Center for Food and Bioconvergence, Seoul National University, Seoul, 08826, Republic of Korea. pschang@snu.ac.kr.

Publikováno v: Scientific reports [Sci Rep] 2024 Oct 05; Vol. 14 (1), pp. 23218. Date of Electronic Publication: 2024 Oct 05.

Nicotinamide as a radiosensitizer in tumours and normal tissues: the importance of drug dose and timing

Autor: Horsman, M R, Siemann, D W, Chaplin, D J, Overgaard, J

Publikováno v: Horsman, M R, Siemann, D W, Chaplin, D J & Overgaard, J 1997, ' Nicotinamide as a radiosensitizer in tumours and normal tissues: the importance of drug dose and timing ', Radiotherapy & Oncology, vol. 45, no. 2, pp. 167-74 .

Nicotinamide is a radiation sensitizer currently undergoing clinical testing. This was an experimental study to determine the importance of drug dose and time interval between drug administration and irradiation for radiosensitization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::9f2a21920ac32539134511ca0c940c20
https://pure.au.dk/portal/da/publications/nicotinamide-as-a-radiosensitizer-in-tumours-and-normal-tissues-the-importance-of-drug-dose-and-timing(de432b66-6f37-4c55-a5d3-65a72b84a42f).html

Reducing acute and chronic hypoxia in tumours by combining nicotinamide with carbogen breathing

Autor: Horsman, Michael Robert, Nordsmark, Marianne, Khalil, Azza Ahmed, Hill, S A, Chaplin, D J, Siemann, D W, Overgaard, Jens

Publikováno v: Horsman, M R, Nordsmark, M, Khalil, A A, Hill, S A, Chaplin, D J, Siemann, D W & Overgaard, J 1994, ' Reducing acute and chronic hypoxia in tumours by combining nicotinamide with carbogen breathing ', Acta Oncologica, vol. 33, no. 4, pp. 371-6 .

The ability of nicotinamide and carbogen breathing to improve the radiation response of a C3H mammary carcinoma by reducing both acute and chronic hypoxia was investigated. Using a tumour growth delay assay the response of 200 mm3 foot tumours to loc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::d9ead6241e2cf39b9c4428480bf08331
https://pure.au.dk/portal/da/publications/reducing-acute-and-chronic-hypoxia-in-tumours-by-combining-nicotinamide-with-carbogen-breathing(580a0092-a8ef-4c31-ad98-4cc12b1ca34d).html

Review; Recent approaches on Tubulin Polymerization inhibitors (2018-2022).

Autor: El-Abd, Azhar O.¹ azhaarosama89@gmail.com, Mansour, Basem¹, Abdel-Aziz, Naglaa I.^1,2, El-Sherbeny, Magda A.^1,2

Publikováno v: Delta University Scientific Journal. Apr2024, Vol. 7 Issue 1, p88-113. 26p.