Transferrin Saturation/Hepcidin Ratio Discriminates TMPRSS6-Related Iron Refractory Iron Deficiency Anemia from Patients with Multi-Causal Iron Deficiency Anemia

Autor: Hilde van der Staaij, Albertine E. Donker, Dirk L. Bakkeren, Jan M. J. I. Salemans, Lisette A. A. Mignot-Evers, Marlies Y. Bongers, Jeanne P. Dieleman, Tessel E. Galesloot, Coby M. Laarakkers, Siem M. Klaver, Dorine W. Swinkels

Publikováno v: International Journal of Molecular Sciences, 23, 3
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1917
International Journal of Molecular Sciences, 23(3):1917. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 23
International Journal of Molecular Sciences, Vol 23, Iss 1917, p 1917 (2022)

Pathogenic TMPRSS6 variants impairing matriptase-2 function result in inappropriately high hepcidin levels relative to body iron status, leading to iron refractory iron deficiency anemia (IRIDA). As diagnosing IRIDA can be challenging due to its geno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e5c04445cd203c0134bbfc3d34d0e5
https://hdl.handle.net/2066/248824

Optimizing hepcidin measurement with a proficiency test framework and standardization improvement

Autor: Thibaud Lefebvre, Andrew E. Armitage, Siem M. Klaver, Laura E. Diepeveen, Outi Itkonen, Naohisa Tomosugi, Dorine W. Swinkels, Marianne Fillet, Markus Rieke, Huiling Han, Ellis T. Aune, Peter Neyer, Daan van de Kerkhof, Aleksandra Krygier, Matthias Herkert, Michael Chen, Sukhvinder S. Bansal, Cas Weykamp, Coby M. Laarakkers

Publikováno v: Clinical Chemistry and Laboratory Medicine, 59(2), 315-323. Walter de Gruyter GmbH
Clinical Chemistry and Laboratory Medicine, 59, 315-323
Clinical Chemistry and Laboratory Medicine, 59, 2, pp. 315-323

Objectives Hepcidin measurement advances insights in pathophysiology, diagnosis, and treatment of iron disorders, but requires analytically sound and standardized measurement procedures (MPs). Recent development of a two-level secondary reference mat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff9b52218613c8b727649c8815d5ceb
https://research.tue.nl/nl/publications/871fb21c-0114-4622-866b-1157dd0aed20

Toward worldwide hepcidin assay harmonization: Identification of a commutable secondary reference material

Autor: Sukhvinder S. Bansal, Naohisa Tomosugi, Natascia Campostrini, Alison Bamberg, Hal Drakesmith, Marianne Fillet, Siem M. Klaver, Jan C.M. Hendriks, Dorine W. Swinkels, Kelly R Pitts, Robert J. Konrad, Gordana Olbina, Sant-Rayn Pasricha, Coby M. Laarakkers, Mark Westerman, Matthias Herkert, Lisa N. van der Vorm, Outi Itkonen, Franco Tagliaro, John H. Sloan, Anneke Geurts-Moespot, Andrew E. Armitage, Domenico Girelli, Cas Weykamp

Publikováno v: Clinical Chemistry, 62, 993-1001
Clinical Chemistry, 62, 7, pp. 993-1001

BACKGROUND Absolute plasma hepcidin concentrations measured by various procedures differ substantially, complicating interpretation of results and rendering reference intervals method dependent. We investigated the degree of equivalence achievable by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329a13f96210211a4fd291a192a03389
http://ora.ox.ac.uk/objects/uuid:

Improved mass spectrometry assay for plasma hepcidin: detection and characterization of a novel hepcidin isoform

Autor: Harold Tjalsma, Dorine W. Swinkels, Andreas Hohlbaum, Maria Kolodziejczyk, Erwin T. Wiegerinck, Hendrik Gille, Coby M. Laarakkers, Siem M. Klaver

Publikováno v: PLoS One, 8, 10
PLoS One, 8
PLoS ONE
PLoS ONE; Vol 8
PLoS ONE, Vol 8, Iss 10, p e75518 (2013)

Contains fulltext : 125929.pdf (Publisher’s version ) (Open Access) Mass spectrometry (MS)-based assays for the quantification of the iron regulatory hormone hepcidin are pivotal to discriminate between the bioactive 25-amino acid form that can eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e60527fc3c3f3a53efa4e041c7f9476
https://hdl.handle.net/2066/125954

(Pre)analytical imprecision, between-subject variability, and daily variations in serum and urine hepcidin: implications for clinical studies

Autor: Harold Tjalsma, Joyce J.C. Kroot, Dorine W. Swinkels, Siem M. Klaver, Coby M. Laarakkers, Erwin H.J.M. Kemna, Jan C.M. Hendriks

Publikováno v: Analytical Biochemistry, 389, 124-9
Analytical Biochemistry, 389, 2, pp. 124-9

Contains fulltext : 81808.pdf (Publisher’s version ) (Closed access) The utility of urine and serum hepcidin measurements in the clinic depends on their reproducibility. We sought to expand our previous work on the within-subject variability and be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff7a60b9435953db7568525802851b8
http://hdl.handle.net/2066/81808