Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Siegfried Raddatz"'
Autor:
Thomas Lampe, Winfried Jöntgen, Siegfried Raddatz, Holger Paulsen, Mathias Berwe, Martin Michels, Jochen Krüger, Stefan Weigand, Yolanda Cancho-Grande
Publikováno v:
Organic Process Research & Development. 15:1348-1357
We describe the evolution of a kilogram-scale synthesis of the protected cyclic tripeptide desoxy-biphenomycin B, based on an early discovery route. The retrosynthetic concept included a macrolactamization strategy to build the core ring system of bi
Autor:
Harald Labischinski, Jordi Benet-Buchholz, Dieter Habich, Veronica Hellwig, Andreas Schumacher, Heike Brötz-Oesterhelt, Rainer Endermann, Berthold Hinzen, Thomas Lampe, Holger Paulsen, Siegfried Raddatz
Publikováno v:
ChemMedChem. 1:689-693
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:241-245
We report the synthesis and pharmacological evaluation of new derivatives of natural dipeptide antibiotic TAN-1057 A, B. In the course of this program, we identified novel analogues of the natural product that display similar antibacterial activity a
Autor:
Helga Rübsamen-Waigmann, Siegfried Raddatz, Olaf Weber, Matthias Hesseling, Jürgen Reefschläger, Dieter Habich
Publikováno v:
Antiviral Chemistry and Chemotherapy. 11:51-59
Novel peptide aldehydes (PAs) were identified as potent inhibitors of human cytomegalovirus (HCMV) in vitro. Although these compounds were highly effective against HCMV, they did not exhibit any activity against murine cytomegalovirus (MCMV). The pur
Autor:
Michael Matzke, Bernd Beckermann, Romanis Fruchtmann, Burkhard Fugmann, Phillip J. Gardiner, John Goossens, Armin Flatzelmann, Bodo Junge, Jörg Keldenich, Christian Kohlsdorfer, Klaus-Helmut Mohrs, Reiner Müller-Peddinghaus, Siegfried Raddatz
Publikováno v:
European Journal of Medicinal Chemistry. 30:441s-451s
Autor:
Kerstin Henninger, Werner Schroeder, Hans-Georg Sahl, Heike Brötz-Oesterhelt, Dieter Beyer, Harald Labischinski, Christoph Ladel, Holger Paulsen, Hein-Peter Kroll, Julia E. Bandow, Berthold Hinzen, Rainer Endermann, Siegfried Raddatz
Publikováno v:
Nature medicine. 11(10)
Here we show that a new class of antibiotics-acyldepsipeptides-has antibacterial activity against Gram-positive bacteria in vitro and in several rodent models of bacterial infection. The acyldepsipeptides are active against isolates that are resistan
Autor:
Michael Brands, Jochen Krueger, Siegfried Raddatz, Vladimir N. Belov, Armin de Meijere, Sofia Nikolskaya, Viktor V. Sokolov
Publikováno v:
ChemInform. 35
Autor:
Yolanda Cancho Grande, Jochen Krueger, Rainer Endermann, Reinhold Gahlmann, Michael Brands, Siegfried Raddatz
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(16)
We report the synthesis and pharmacological evaluation of new derivatives of the natural dipeptide antibiotic TAN 1057 A,B containing heterocycles either in the beta-amino acid side chain or as mimics of the urea function. In the course of this progr
Autor:
Siegfried Raddatz, Armin de Meijere, Viktor V. Sokolov, Gahlmann Reinhold, Jochen Krüger, Vladimir N. Belov, Rainer Endermann, Shamil Nizamov, Michael Brands, Jürgen Stoltefuss
Publikováno v:
Journal of medicinal chemistry. 45(19)
The natural dipeptide antibiotic TAN 1057 A,B displays excellent antibacterial activity against staphylococci including methicillin resistant Staphylococcus aureus. However, the in vitro activity against additional Gram-positive strains, in particula
Autor:
Andreas Schumacher, Dieter Habich, Harald Labischinski, Heike Brötz-Oesterhelt, Holger Paulsen, Thomas Lampe, Siegfried Raddatz, Jordi Benet-Buchholz, Berthold Hinzen, Veronica Hellwig, Rainer Endermann
Publikováno v:
ChemMedChem. 1:661-661