Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Siegfried, Scherneck"'
Autor:
W. Hofmann, Siegfried Scherneck, Manfred Schwab, Katrin Arnold, Volker Ehemann, Andreas Claas, Evgeny Sagulenko, Vitaliya Sagulenko, Larissa Savelyeva
Publikováno v:
Cancer Letters. 257:65-72
Mounting evidence implicates BRCA2 not only in maintenance of genome integrity but also in cell-cycle checkpoints. However, the contribution of BRCA2 in the checkpoints is still far from being understood. Here, we demonstrate that breast cancer cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324e353f73fa436efabfd1e8ea915d08
https://doi.org/10.1016/j.canlet.2007.07.003
https://doi.org/10.1016/j.canlet.2007.07.003
Autor:
Siegfried Scherneck, Muhsin Özel, Rainer Ulrich, Paul Pumpens, Tatyana Voronkova, Velta Ose, Andris Kazaks
Publikováno v:
Virus Genes. 34:303-314
The authentic major capsid protein 1 (VP1) of hamster polyomavirus (HaPyV) consists of 384 amino acid (aa) residues (42 kDa). Expression from an additional in-frame initiation codon located upstream from the authentic VP1 open reading frame (at posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc95cb210bafd4a38493f1946c59ea3
https://doi.org/10.1007/s11262-006-0028-1
https://doi.org/10.1007/s11262-006-0028-1
Autor:
Siegfried Scherneck, Stefan Mundlos, Morteza Atri, S. Said Hosseini-Asl, Parvin Mehdipour, Andrea Pietschmann, Hartmut Peters, W. Hofmann
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 131:552-558
Purpose: Germline mutations in either BRCA1 or BRCA2 genes are responsible for the majority of hereditary breast and ovarian cancers. At present, over thousand distinct BRCA1 and BRCA2 mutations have been identified. Specific mutations are found to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6285b7fdeff4d8dd61486b6cd41b22
https://doi.org/10.1007/s00432-005-0678-8
https://doi.org/10.1007/s00432-005-0678-8
Autor:
Christiane Klebig, Susanne Seitz, Wolfgang Arnold, Nicole Deutschmann, Manuela Pacyna-Gengelbach, Siegfried Scherneck, Iver Petersen
Publikováno v:
Cancer Research. 65:394-400
Frequent allelic loss of the chromosomal region 17p13 in breast cancer has suggested that more tumor suppressor genes, besides p53, are located in this region. By doing suppression subtractive hybridization to detect differentially expressed genes be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb55e46037137be1a8a12f19b71f381
https://doi.org/10.1158/0008-5472.394.65.2
https://doi.org/10.1158/0008-5472.394.65.2
Autor:
Javier Benitez, Siegfried Scherneck, Douglas F. Easton, Michael R. Stratton, Christine Maugard, Jocelyne Jacquemier, Suzanne Parry, G Evans, Jenny Varley, Teresa Wagner, Yves-Jean Bignon, L G Fulford, Carolin Nestle-Krämling, Jan G. M. Klijn, Jorge S. Reis-Filho, Fiona Lalloo, Frédérique Penault-Llorca, Rivas C, Marc van der Vijver, Lesley McGuffog, Neva E. Haites, Matthias W. Beckmann, Peter Devilee, Julian Peto, Cees J. Cornelisse, Ute Hamann, Sunil R. Lakhani, Edith Olah, Jenny Chang-Claude, Timothy Bishop, Peter A. Daly, Hanne Meijers-Heijboer, Paolo Radice, Hagay Sobol, Silvana Pilotti, Barry A. Gusterson
Publikováno v:
Clinical cancer research, 11(14), 5175-5180. American Association for Cancer Research Inc.
Clinical Cancer Research, 11(14), 5175-5180. American Association for Cancer Research Inc.
Clinical Cancer Research, 11(14), 5175-5180. American Association for Cancer Research Inc.
Purpose: To investigate the proportion of breast cancers arising in patients with germ line BRCA1 and BRCA2 mutations expressing basal markers and developing predictive tests for identification of high-risk patients. Experimental Design: Histopatholo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954fc752e5c7e45beab91253ead2308c
https://doi.org/10.1158/1078-0432.CCR-04-2424
https://doi.org/10.1158/1078-0432.CCR-04-2424
Autor:
Siegfried Scherneck, Susanne Seitz, Eberhard Korsching, Glen Kristiansen, Iver Petersen, Dirk Gustavus, Christiane Klebig
Publikováno v:
Genes, Chromosomes and Cancer. 44:233-246
Previous studies have shown that transfer of chromosome 17 suppresses the tumorigenic phenotype of the breast cancer cell line CAL51, suggesting the presence of putative tumor suppressor genes on this chromosome. Suppression subtractive hybridization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e783c76ac79f6cf4ba2ebc0557d15088
https://doi.org/10.1002/gcc.20240
https://doi.org/10.1002/gcc.20240
Autor:
Siegfried Scherneck, Jörg Weimer, Susanne Seitz, Norbert Arnold, Wolfgang Arnold, Anja Jacobsen, Dieter Niederacher, Clarissa von Haefen, Rita K. Schmutzler, Renate Frege
Publikováno v:
Oncogene. 24:869-879
Several investigations have supposed that tumor suppressor genes might be located on human chromosome 8. We used microcell-mediated transfer of chromosome 8 into MDA-MB-231 breast cancer cells and generated independent hybrids with strongly reduced t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4388c50fd2586d27b1957bed5fb758b
https://doi.org/10.1038/sj.onc.1208260
https://doi.org/10.1038/sj.onc.1208260
Autor:
Siegfried Scherneck, Katrin Bandick, Alfons Meindl, Michael R. Dufault, Kerstin Rhiem, Christine Hüttner, Celia von Lindern, Caroline Nestle-Krämling, Rita K. Schmutzler, Astrid Golla, Beate Betz, W. Hofmann, Barbara Wappenschmidt, Peter Dall, Marion Kiechle, Walter Jonat, Michael Untch, Dieter Niederacher, Norbert Arnold, Andrea Pietschmann
Publikováno v:
International Journal of Cancer. 110:320-325
To establish the importance of CHEK2 mutations for familial breast cancer incidence in the German population, we have screened all 14 of the coding exons in 516 families negative for mutations in both the BRCA1 and BRCA2 genes. We found 12 distinct v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f84983ef5439bc44a0a5e7e060317946
https://doi.org/10.1002/ijc.20073
https://doi.org/10.1002/ijc.20073
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 129:349-354
The chromosome region 8p12-p22 shows frequent allelic loss in many neoplasms, including breast cancer (BC). The DLC-1 gene, located on 8p21-p22, might be a candidate tumor suppressor gene in this region. To evaluate the involvement of DLC-1 in breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c5e75fe4c6485e3af560874d2bdb62
https://doi.org/10.1007/s00432-003-0440-z
https://doi.org/10.1007/s00432-003-0440-z
Autor:
Lope-Estevez Schwarz, André Rosenthal, Siegfried Scherneck, Elke Burkhard-Goettges, Bernd Hinzmann, Constanze Zeller, Jörg Fischer, Susanne Seitz, H. Prokoph, Burkhard Jandrig
Publikováno v:
Oncogene. 22:2972-2983
Loss of heterozygosity (LOH) and in silico expression analysis were applied to identify genes significantly downregulated in breast cancer within the genomic interval 6q23-25. Systematic comparison of candidate EST sequences with genomic sequences fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ac9f29aa4a910ff34ea4dd78e9c61f
https://doi.org/10.1038/sj.onc.1206474
https://doi.org/10.1038/sj.onc.1206474