Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Siegfried, Scherer"'
Publikováno v:
BMC Microbiology, Vol 23, Iss 1, Pp 1-17 (2023)
Abstract Analysis of genome wide transcription start sites (TSSs) revealed an unexpected complexity since not only canonical TSS of annotated genes are recognized by RNA polymerase. Non-canonical TSS were detected antisense to, or within, annotated g
Externí odkaz:
https://doaj.org/article/f510639c8a714ebf8328cac2ebb88923
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT The abundance of long overlapping genes in prokaryotic genomes is likely to be significantly underestimated. To date, only a few examples of such genes are fully established. Using RNA sequencing and ribosome profiling, we found expression o
Externí odkaz:
https://doaj.org/article/a433a119bb7b48bc91202fe9ec9dc259
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-17 (2021)
Abstract Background Overlapping genes (OLGs) with long protein-coding overlapping sequences are disallowed by standard genome annotation programs, outside of viruses. Recently however they have been discovered in Archaea, diverse Bacteria, and Mammal
Externí odkaz:
https://doaj.org/article/a971e693dd394be18249b3900e2ba668
Autor:
Michaela Kreitmeier, Zachary Ardern, Miriam Abele, Christina Ludwig, Siegfried Scherer, Klaus Neuhaus
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103844- (2022)
Summary: The existence of overlapping genes (OLGs) with significant coding overlaps revolutionizes our understanding of genomic complexity. We report two exceptionally long (957 nt and 1536 nt), evolutionarily novel, translated antisense open reading
Externí odkaz:
https://doaj.org/article/585906a4fe2f4b3bbb35195c898f516c
Autor:
Kirill V. Ovchinnikov, Christian Kranjec, Amar Telke, Morten Kjos, Tage Thorstensen, Siegfried Scherer, Harald Carlsen, Dzung B. Diep
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Antibiotic-resistant bacterial pathogens have become a serious threat worldwide. One of these pathogens is methicillin-resistant Staphylococcus aureus (MRSA), a major cause of skin and soft tissue infections. In this study we identified a strain of S
Externí odkaz:
https://doaj.org/article/26f19e1b9a2846b2a1c2732fb385b2bf
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Many prokaryotic RNAs are transcribed from loci outside of annotated protein coding genes. Across bacterial species hundreds of short open reading frames antisense to annotated genes show evidence of both transcription and translation, for instance i
Externí odkaz:
https://doaj.org/article/8db1fb06beeb4d109975e08fd4bb8e30
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Raw milk microbiota are complex communities with a significant impact on the hygienic, sensory and technological quality of milk products. However, there is a lack of knowledge on factors determining their composition. In the present study, four bulk
Externí odkaz:
https://doaj.org/article/e75ed61e091f4357a6b7030b65bc0ded
Autor:
Christopher Maier, Christopher Huptas, Mario von Neubeck, Siegfried Scherer, Mareike Wenning, Genia Lücking
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Psychrotolerant Pseudomonas species are a main cause of proteolytic spoilage of ultra-high temperature (UHT) milk products due to the secretion of the heat-resistant metallopeptidase AprX, which is encoded by the first gene of the aprX-lipA2 operon.
Externí odkaz:
https://doaj.org/article/fc6ea853275a4ebaa36f8392410a7e31
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Antisense transcription is well known in bacteria. However, translation of antisense RNAs is typically not considered, as the implied overlapping coding at a DNA locus is assumed to be highly improbable. Therefore, such overlapping genes are systemat
Externí odkaz:
https://doaj.org/article/c92dee358fb74b49aa5f49dcc0a853bf
Autor:
Sarah M. Hücker, Sonja Vanderhaeghen, Isabel Abellan-Schneyder, Romy Wecko, Svenja Simon, Siegfried Scherer, Klaus Neuhaus
Publikováno v:
BMC Evolutionary Biology, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background Due to the DNA triplet code, it is possible that the sequences of two or more protein-coding genes overlap to a large degree. However, such non-trivial overlaps are usually excluded by genome annotation pipelines and, thus, only a
Externí odkaz:
https://doaj.org/article/25657c3cf0e94bad844b5da3bcce1797