Zobrazeno 1 - 10 of 149 pro vyhledávání: '"Siegfried, Hekimi"'
1
Akademický článek
Minimal mitochondrial respiration is required to prevent cell death by inhibition of mTOR signaling in CoQ-deficient cells
Autor: Ying Wang, Siegfried Hekimi
Publikováno v: Cell Death Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract Coenzyme Q (CoQ) is a lipid-like mobile electron transporter of the mitochondrial respiratory chain. Patients with partial loss-of-function mutations in the CoQ biosynthesis pathway suffer from partial primary CoQ deficiency (MIM 607426). Th
Externí odkaz: https://doaj.org/article/283e381da5924404aba161207ba3af3b
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2
Akademický článek
A novel COQ7 mutation causing primarily neuromuscular pathology and its treatment options
Autor: Ying Wang, Evren Gumus, Siegfried Hekimi
Publikováno v: Molecular Genetics and Metabolism Reports, Vol 31, Iss , Pp 100877- (2022)
Coenzyme Q10 (CoQ10) is necessary as electron transporter in mitochondrial respiration and other cellular functions. CoQ10 is synthesized by all cells and defects in the synthesis pathway result in primary CoQ10 deficiency that frequently leads to se
Externí odkaz: https://doaj.org/article/9ee5763dfc5b40acb3fbac7f38fb3a10
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3
Akademický článek
Micellization of coenzyme Q by the fungicide caspofungin allows for safe intravenous administration to reach extreme supraphysiological concentrations
Autor: Ying Wang, Siegfried Hekimi
Publikováno v: Redox Biology, Vol 36, Iss , Pp 101680- (2020)
Coenzyme Q10 (CoQ10; also known as ubiquinone) is a vital, redox-active membrane component that functions as obligate electron transporter in the mitochondrial respiratory chain, as cofactor in other enzymatic processes and as antioxidant. CoQ10 supp
Externí odkaz: https://doaj.org/article/92fa4f4ce10a493c85190e1a247387d5
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4
Akademický článek
ROS regulation of RAS and vulva development in Caenorhabditis elegans.
Autor: Maximilian Kramer-Drauberg, Ju-Ling Liu, David Desjardins, Ying Wang, Robyn Branicky, Siegfried Hekimi
Publikováno v: PLoS Genetics, Vol 16, Iss 6, p e1008838 (2020)
Reactive oxygen species (ROS) are signalling molecules whose study in intact organisms has been hampered by their potential toxicity. This has prevented a full understanding of their role in organismal processes such as development, aging and disease
Externí odkaz: https://doaj.org/article/e686a5d7bd7d4135b665c7a441c8701a
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5
Akademický článek
A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1
Autor: Ju-Ling Liu, Callista Yee, Ying Wang, Siegfried Hekimi
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The Caenorhabditis elegans clk-1 gene and the orthologous mouse gene Mclk1 encode a mitochondrial hydroxylase that is necessary for the biosynthesis of ubiquinone (UQ). Mutations in these genes produce broadly pleiotropic phenotypes in both
Externí odkaz: https://doaj.org/article/48cfd64f41a4454ca95fb1e221c9305e
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