Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Siegen A. McKellar"'
Autor:
Austin M. Gabel, Andrea E. Belleville, James D. Thomas, Siegen A. McKellar, Taylor R. Nicholas, Toshihiro Banjo, Edie I. Crosse, Robert K. Bradley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Alternative polyadenylation (APA) is strikingly dysregulated in many cancers. Although global APA dysregulation is frequently associated with poor prognosis, the importance of most individual APA events is controversial simply because few ha
Externí odkaz:
https://doaj.org/article/38f1b82c8b184f27a198e5de36ed4995
Autor:
Daniel Haensel, Ramon J. Whitson, Gautam Shankar, Anthony E. Oro, Catherine D. Yao, Kavita Y. Sarin, Sumaira Z. Aasi, Sadhana Gaddam, T. Patel, Scott X. Atwood, Siegen A. McKellar, Kerri E. Rieger
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Tumor heterogeneity and lack of knowledge about resistant cell states remain a barrier to targeted cancer therapies. Basal cell carcinomas (BCCs) depend on Hedgehog (Hh)/Gli signaling, but can develop mechanisms of Smoothened (SMO) inhibitor resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f1e87d073ff7d1c8b34fb6d4dc7229d
https://escholarship.org/uc/item/0q90h5pk
https://escholarship.org/uc/item/0q90h5pk
Autor:
Siegen A. McKellar, Sumaira Z. Aasi, A. Mirza, Tyler Hollmig, Nicole M. Urman, Anthony E. Oro, Alexander S. Brown
Publikováno v:
Cell. 176(1-2)
Understanding transcription factor navigation through the nucleus remains critical for developing targeted therapeutics. The GLI1 transcription factor must maintain maximal Hedgehog pathway output in basal cell carcinomas (BCCs), and we have previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68520e96b1d7ad3164b7848d6cebe1c9
https://pubmed.ncbi.nlm.nih.gov/30503211
https://pubmed.ncbi.nlm.nih.gov/30503211