Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Siebren Frölich"'
Autor:
Julian A. Arts, Siebren Frölich, Jos G.A. Smits, Huiqing Zhou, Joost H.A. Martens, Simon J. van Heeringen, Rebecca R. Snabel, Branco M.H. Heuts
Publikováno v:
F1000Research, Vol 12 (2023)
The recent development of single-cell techniques is essential to unravel complex biological systems. By measuring the transcriptome and the accessible genome on a single-cell level, cellular heterogeneity in a biological environment can be deciphered
Externí odkaz:
https://doaj.org/article/48bec8de53344c7f8dd77ff0ab226379
Autor:
Maarten van der Sande, Siebren Frölich, Tilman Schäfers, Jos G.A. Smits, Rebecca R. Snabel, Sybren Rinzema, Simon J. van Heeringen
Publikováno v:
PeerJ, Vol 11, p e16380 (2023)
Sequencing databases contain enormous amounts of functional genomics data, making them an extensive resource for genome-scale analysis. Reanalyzing publicly available data, and integrating it with new, project-specific data sets, can be invaluable. W
Externí odkaz:
https://doaj.org/article/c85e670403b149f599a9909984f62f87
Autor:
Roelof A. Wester, Lisa van Voorthuijsen, Hannah K. Neikes, Jelmer J. Dijkstra, Lieke A. Lamers, Siebren Frölich, Maarten van der Sande, Colin Logie, Rik G.H. Lindeboom, Michiel Vermeulen
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103444- (2021)
Summary: Retinoic acid (RA) signaling is an important and conserved pathway that regulates cellular proliferation and differentiation. Furthermore, perturbed RA signaling is implicated in cancer initiation and progression. However, the mechanisms by
Externí odkaz:
https://doaj.org/article/ee53bbefaa5245eea4b658c2b77ce466
Publikováno v:
Biochemical Society Transactions, 51, 1-12
Biochemical Society Transactions, 51, 1, pp. 1-12
Biochemical Society Transactions, 51, 1, pp. 1-12
Gene regulatory networks (GRNs) serve as useful abstractions to understand transcriptional dynamics in developmental systems. Computational prediction of GRNs has been successfully applied to genome-wide gene expression measurements with the advent o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15aaad3e23d930ea8efb3b541bf6bddc
https://hdl.handle.net/2066/292449
https://hdl.handle.net/2066/292449
Publikováno v:
Bioinformatics, 39, 3, pp. 1-3
Bioinformatics, 39, 1-3
Bioinformatics, 39, 1-3
MotivationAnalyzing a functional genomics experiment, such as ATAC-, ChIP-, or RNA-sequencing, requires genomic resources such as a reference genome assembly and gene annotation. These data can generally be retrieved from different organizations and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f8444ae0106d583be47c6ee2c36a4b
https://doi.org/10.1093/bioinformatics/btad119
https://doi.org/10.1093/bioinformatics/btad119
Autor:
Jos G.A. Smits, Julian A. Arts, Siebren Frölich, Rebecca R. Snabel, Branco M.H. Heuts, Joost H.A. Martens, Simon J. van Heeringen, Huiqing Zhou
Publikováno v:
F1000Research. 12:243
The recent development of single-cell techniques is essential to unravel complex biological systems. By measuring the transcriptome and the accessible genome on a single-cell level, cellular heterogeneity in a biological environment can be deciphered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7fb6a6872d8b47f8c493a903012b3bd
https://doi.org/10.12688/f1000research.130530.1
https://doi.org/10.12688/f1000research.130530.1
Autor:
Colin Logie, Maarten van der Sande, Michiel Vermeulen, Lisa van Voorthuijsen, Lieke A. Lamers, Jelmer J. Dijkstra, Roelof A. Wester, Siebren Frölich, Hannah K. Neikes, Rik G.H. Lindeboom
Publikováno v:
iScience
iScience, Vol 24, Iss 12, Pp 103444-(2021)
iScience, 24, 12, pp. 1-17
iScience, 24, 1-17
iScience, Vol 24, Iss 12, Pp 103444-(2021)
iScience, 24, 12, pp. 1-17
iScience, 24, 1-17
Summary Retinoic acid (RA) signaling is an important and conserved pathway that regulates cellular proliferation and differentiation. Furthermore, perturbed RA signaling is implicated in cancer initiation and progression. However, the mechanisms by w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47801f32a1b149a8867e2c9bb8994cf1
Autor:
Siebren Frölich, Gert Jan C. Veenstra, Qingqing Li, Simon J. van Heeringen, Siebe T. van Genesen, Ann Rose Bright, Alexia Grasso, Maarten van der Sande
Publikováno v:
EMBO Journal
During vertebrate gastrulation, mesoderm is induced in pluripotent cells, concomitant with dorsal-ventral patterning and establishing of the dorsal axis. We applied single-cell chromatin accessibility and transcriptome analyses to explore the emergen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6718f68105f2e76d35c009761f4e16bc
https://hdl.handle.net/2066/230846
https://hdl.handle.net/2066/230846
Autor:
Maarten van der Sande, Quan Xu, Simon J. van Heeringen, Georgios Georgiou, Huiqing Zhou, Siebren Frölich, Gert Jan C. Veenstra
Publikováno v:
Nucleic Acids Research, 49, 7966-7985
Nucleic Acids Research
Nucleic Acids Research, 49, 14, pp. 7966-7985
Nucleic Acids Research
Nucleic Acids Research, 49, 14, pp. 7966-7985
Proper cell fate determination is largely orchestrated by complex gene regulatory networks centered around transcription factors. However, experimental elucidation of key transcription factors that drive cellular identity is currently often intractab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936c764f3721ac86a4609101440896ee
https://doi.org/10.1101/2020.06.05.135798
https://doi.org/10.1101/2020.06.05.135798
Autor:
Srividya Ganapathy, Sarah Radwan, Johan Lugtenburg, Klaas J. Hellingwerf, Hanka Venselaar, Que Chen, Siebren Frölich, Willem J. de Grip, Odette Bécheau, Jeroen B. van der Steen, Huub J. M. de Groot
Publikováno v:
Biochemical Journal, 467(2), 333-343
Biochemical Journal, 467, 2, pp. 333-43
Biochemical Journal, 467(2), 333-343. Portland Press Ltd.
Biochemical Journal, 467, 333-43
Biochemical Journal, 467, 2, pp. 333-43
Biochemical Journal, 467(2), 333-343. Portland Press Ltd.
Biochemical Journal, 467, 333-43
Contains fulltext : 153410.pdf (Publisher’s version ) (Closed access) Proteorhodopsins are heptahelical membrane proteins which function as light-driven proton pumps. They use all-trans-retinal A1 as a ligand and chromophore and absorb visible ligh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155928993bf55fefa1c1c7ed13012fdd
http://hdl.handle.net/1887/3198447
http://hdl.handle.net/1887/3198447