Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Siebe Loontiens"'
Autor:
Charlotte Fieuws, Joni Van der Meulen, Kristiaan Proesmans, Emiel A. De Jaeghere, Siebe Loontiens, Jo Van Dorpe, Philippe Tummers, Hannelore Denys, Koen Van de Vijver, Kathleen B. M. Claes
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-9 (2024)
Abstract Ovarian cancer is the most lethal gynecologic malignancy, mainly due to late-stage diagnosis, frequent recurrences, and eventually therapy resistance. To identify potentially actionable genetic variants, sequencing data of 351 Belgian ovaria
Externí odkaz:
https://doaj.org/article/5c37a68cc4e94950a526a81909a826e3
Autor:
Bieke Decaesteker, Amber Louwagie, Siebe Loontiens, Fanny De Vloed, Sarah-Lee Bekaert, Juliette Roels, Suzanne Vanhauwaert, Sara De Brouwer, Ellen Sanders, Alla Berezovskaya, Geertrui Denecker, Eva D’haene, Stéphane Van Haver, Wouter Van Loocke, Jo Van Dorpe, David Creytens, Nadine Van Roy, Tim Pieters, Christophe Van Neste, Matthias Fischer, Pieter Van Vlierberghe, Stephen S. Roberts, Johannes Schulte, Sara Ek, Rogier Versteeg, Jan Koster, Johan van Nes, Mark Zimmerman, Katleen De Preter, Frank Speleman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
The development of neuroblastoma (NB) is regulated by multiple core transcription factors. Here, SOX11 is identified as a potential epigenetic master regulator upstream of the core regulatory circuitry in adrenergic high-risk neuroblastoma.
Externí odkaz:
https://doaj.org/article/c5e038d1e2b747e4b27f9e8e90add70c
Autor:
Siebe Loontiens, Lisa Depestel, Suzanne Vanhauwaert, Givani Dewyn, Charlotte Gistelinck, Karen Verboom, Wouter Van Loocke, Filip Matthijssens, Andy Willaert, Jo Vandesompele, Frank Speleman, Kaat Durinck
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-16 (2019)
Abstract Background Transgenic zebrafish lines with the expression of a fluorescent reporter under the control of a cell-type specific promoter, enable transcriptome analysis of FACS sorted cell populations. RNA quality and yield are key determinant
Externí odkaz:
https://doaj.org/article/acfc64ccb81d44cd82fb56d1745572ab
Autor:
Bieke Decaesteker, Geertrui Denecker, Christophe Van Neste, Emmy M. Dolman, Wouter Van Loocke, Moritz Gartlgruber, Carolina Nunes, Fanny De Vloed, Pauline Depuydt, Karen Verboom, Dries Rombaut, Siebe Loontiens, Jolien De Wyn, Waleed M. Kholosy, Bianca Koopmans, Anke H. W. Essing, Carl Herrmann, Daniel Dreidax, Kaat Durinck, Dieter Deforce, Filip Van Nieuwerburgh, Anton Henssen, Rogier Versteeg, Valentina Boeva, Gudrun Schleiermacher, Johan van Nes, Pieter Mestdagh, Suzanne Vanhauwaert, Johannes H. Schulte, Frank Westermann, Jan J. Molenaar, Katleen De Preter, Frank Speleman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
In high-risk neuroblastoma cases, gains in chromosome 17q are common. Here, the authors investigate the epigenomics and transcriptomics of neuroblastoma, identifying TBX2 as a core regulatory circuitry component enhancing the reactivation of DREAM ta
Externí odkaz:
https://doaj.org/article/536b907629694780b1f507b113373066
Autor:
Siebe Loontiens, Anne-Catherine Dolens, Steven Strubbe, Inge Van de Walle, Finola E. Moore, Lisa Depestel, Suzanne Vanhauwaert, Filip Matthijssens, David M. Langenau, Frank Speleman, Pieter Van Vlierberghe, Kaat Durinck, Tom Taghon
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Transcriptional control of hematopoiesis involves complex regulatory networks and functional perturbations in one of these components often results in malignancies. Loss-of-function mutations in PHF6, encoding a presumed epigenetic regulator, have be
Externí odkaz:
https://doaj.org/article/5648833cfe364bd6bb29257e785baafe
Autor:
Lisa Depestel, Ellen Sanders, Sarah-Lee Bekaert, Carolien Van Damme, Aline Eggermont, Siebe Loontiens, Laurentijn Tilleman, Filip Van Nieuwerburgh, Jan Willem Bek, Louis Delhaye, Pieter Van Vlierberghe, Sven Eyckerman, Kaat Durinck
The ‘plant homeodomain zinc finger protein 6’ (PHF6) is affected by germline mutations in patients with cognitive disabilities and somatic mutations in acute T-cell leukemia (T-ALL). We and others previously obtained evidence for a key role of PH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60f7e6c1958346dcf2a44d2df53951b3
https://doi.org/10.1101/2023.03.08.531704
https://doi.org/10.1101/2023.03.08.531704
Autor:
Elina Fredlund, Stina Andersson, Elien Hilgert, Guadalupe Álvarez-Hernán, Ezequiel Monferrer, Sinan Karakaya, Tomas Gregor, Siebe Loontiens, Jan Willem Bek, Estelle Lecomte, Emma Magnusson, Enrika Miltenyte, Marie Cabirol, Michail Kyknas, Niklas Engström, Marie Arsenian Henriksson, Emma Hammarlund, Rosa Noguera, Frank Speleman, Johan van Nes, Sofie Mohlin
Neuroblastoma is a childhood cancer believed to result from dysfunctional development. Its origin during embryogenesis remains poorly understood. The lack of appropriate models has hindered in-depth mapping of tumor-driving events. Here, we identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d30d650819002dbe172d6ed75f44c405
https://doi.org/10.1101/2023.01.17.524367
https://doi.org/10.1101/2023.01.17.524367
Autor:
Elina Fredlund, Stina Andersson, Elien Hilgert, Guadalupe Alvares Hernan, Ezequiel Monferrer, Sinan Karakaya, Tomas Gregor, Siebe Loontiens, Jan Willem Bek, Estelle Lecomte, Emma Magnusson, Enrika Miltenyte, Marie Cabirol, Michail Kyknas, Niklas Engström, Marie Arsenain-Henriksson, Emma Hammarlund, Rosa Noguera, Frank Speleman, Johan van Nes, Sofie Mohlin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebbce025a7678d428c5db79a41b48d56
https://doi.org/10.2139/ssrn.4367309
https://doi.org/10.2139/ssrn.4367309
Autor:
Fleur Cordier, Siebe Loontiens, Joni Van der Meulen, Lore Lapeire, Gabrielle H. van Ramshorst, Gwen Sys, Jo Van Dorpe, David Creytens
Publikováno v:
International Journal of Surgical Pathology. :106689692311674
We report an exceptional case of a spindle cell mesenchymal tumor with S100 and CD34 co-reactivity, which harbored a SLMAP::RAF1 fusion. To the best of our knowledge, this is the second case of a spindle cell mesenchymal tumor with S100 and CD34 co-r
Autor:
Saara Laukkanen, Alexandra Veloso, Chuan Yan, Laura Oksa, Eric J. Alpert, Daniel Do, Noora Hyvärinen, Karin McCarthy, Abhinav Adhikari, Qiqi Yang, Sowmya Iyer, Sara P. Garcia, Annukka Pello, Tanja Ruokoranta, Sanni Moisio, Sadiksha Adhikari, Jeffrey A. Yoder, Kayleigh Gallagher, Lauren Whelton, James R. Allen, Alex H. Jin, Siebe Loontiens, Merja Heinäniemi, Michelle Kelliher, Caroline A. Heckman, Olli Lohi, David M. Langenau
Publikováno v:
Blood. 140(17)
Relapse and refractory T-cell acute lymphoblastic leukemia (T-ALL) has a poor prognosis, and new combination therapies are sorely needed. Here, we used an ex vivo high-throughput screening platform to identify drug combinations that kill zebrafish T-