Výsledky vyhledávání - "Sidwell, R W"

Is the Anti-Psychotic, 10-(3-(Dimethylamino)propyl)phenothiazine (Promazine), a Dangerous Drug with Which to TreatSARS Infections? Efficacy of Promazine on SARS-CoV Replication in a Mouse Model

Autor: Barnard, Dale L., Day, C. W., Bailey, K., Heiner, M., Montgomery, R., Lauridsen, L., Jung, K. H., Chan, P. K., Li, J. K., Sidwell, R. W.

Publikováno v: Animal, Dairy, and Veterinary Science Faculty Publications

Phenothiazine and derivatives were tested for inhibition of SARS-CoV replication. Phenothiazine slightly inhibited SARS-CoV replication in a neutral red (NR) uptake assay. Adding a propylamino group to give promazine reduced virus yields (VYR assay)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1459::47103d1d4c8ee8be943726d24797f437
https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=1533&context=advs_facpub

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Efficacy of Orally Administered T-705 on Lethal Avian Influenza A (H5N1) Virus Infections in Mice

Autor: Sidwell, R. W., Barnard, Dale L., Day, C. W., Smee, Donald F., Bailey, K. W., Wong, M. H., Morrey, John D., Furuta, Y.

Publikováno v: John D. Morrey

T-705 (6-fluoro-3-hydroxy-2-pyrazinecarboxamide) was inhibitory to four strains of avian H5N1 influenza virus in MDCK cells, with the 90% effective concentrations ranging from 1.3 to 7.7 µM, as determined by a virus yield reduction assay. The effica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1459::d8f3869b00b7edf872a5d4fe381620ae
http://works.bepress.com/cgi/viewcontent.cgi?article=1000&context=john_morrey

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Topical Cidofovir Is More Effective than Is Parenteral Therapy for Treatment of Progressive Vaccinia in Immunocompromised Mice

Autor: Smee, Donald F., Bailey, K. W., Wong, M-H., Wandersee, M. K., Sidwell, R. W.

Publikováno v: Animal, Dairy, and Veterinary Science Faculty Publications

Background.Severe complications may arise as a result of virus dissemination after smallpox (live vaccinia virus) vaccination, particularly in immunocompromised individuals. We developed a new mouse model for studying the effects of antiviral agents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1459::9477aff476d5ecf24226b14c1c8e5e2a
https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=1412&context=advs_facpub

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Inhibition of Severe Acute Respiratory Syndrome-Associated Coronavirus (SARSCoV) by Calpain Inhibitors and Beta-D-N4-Hydroxycytidine

Autor: Barnard, Dale L., Hubbard, V. D., Burton, J., Smee, Donald F., Morrey, John D., Otto, M., Sidwell, R. W.

Publikováno v: Animal, Dairy, and Veterinary Science Faculty Publications

We evaluated two types of compounds for efficacy in inhibiting SARSCoV replication in vitro: calpain inhibitors (a class of cellular cysteine proteinases) and a number of nucleoside analogues. Cytopathic effect reduction assays visually determined wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1459::f7472e27e5b05073b8e86f6cea2e2f4f
https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=1401&context=advs_facpub

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Utilization of alpha-1-acid glycoprotein levels in the serum as a parameter for in vivoassay of influenza virus inhibitors. Antivir Chem Chemother

Autor: Sidwell, R. W., Wong, M. H., Bailey, K. W., Barnard, Dale L., Jackson, M. K., Smee, Donald F.

Publikováno v: Animal, Dairy, and Veterinary Science Faculty Publications

Alpha-1-acid glycoprotein (AGP), an acute phase protein in serum assayed by single radial immunodiffusion using a commercially available kit, was found to significantly increase in mice infected with influenza A and B viruses. Experiments were run to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1459::b3f3729e4fa816bf74a9b33518fae357
https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=1540&context=advs_facpub

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In vivo influenza virus-inhibitory effects of the cyclopentane neuraminidase inhibitor RJW-270201

Autor: Sidwell, R W, Smee, D F, Huffman, J H, Barnard, D L, Bailey, K W, Morrey, John D, Babu, Y S

Publikováno v: John D. Morrey

The cyclopentane inﬂuenza virus neuraminidase inhibitor RWJ-270201 was evaluated against inﬂuenza A/NWS/33 (H1N1), A/Shangdong/09/93 (H3N2), A/Victoria/3/75 (H3N2), and B/Hong Kong/05/72 virus infections in mice. Treatment was by oral gavage twic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1459::cc54633c1205ddb260ea1f5e2ab0d1ea
http://works.bepress.com/john_morrey/85

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Inhibition of measles virus replication by 5'-Norcarbocyclic nucleoside analogs

Autor: Barnard, Dale L., Stowell, V., Seley, K. L., Hegde, V. R., Subha, R., Rajappan, P., Schneller, S. W., Smee, Donald F., Sidwell, R. W.

Publikováno v: Animal, Dairy, and Veterinary Science Faculty Publications

Despite intense efforts to increase vaccine coverage, measles virus (MV) still causes significant morbidity and mortality in the world, sometimes as the result of severe, chronic, lethal disease. In an effort to develop therapies to supplement immuni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1459::a3de5cfb4e4d525a69ef7d6b5f02268b
https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=1544&context=advs_facpub

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Acyclic phosphonomethylether nucleosideinhibitors of respiratory viruses

Autor: Barnard, Dale L., Bischofberger, N., Kim, C. U., Huffman, J. H., Sidwell, R. W., Dougherty, J. P., Lew, W., Williams, M. A., Yang, W.

Publikováno v: Animal, Dairy, and Veterinary Science Faculty Publications

A series of acyclic phosphonomethylether nucleosides were synthesized and then evaluated for inhibitory activity against respiratory viruses of clinical significance using CPE inhibition, neutral red uptake and virus yield reduction assays. Of the 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1459::d59b1bb77214ca4da27b6cb5c611763d
https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=1556&context=advs_facpub

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In vitro influenza virus-inhibitory effects of a series of germanium- orsilicon-centered polyoxometalates

Autor: Huffman, J. H., Sidwell, R. W., Barnard, Dale L., Morrison, A., Otto, M. I., Hill, C. L., Schinazi, R. F.

Publikováno v: Animal, Dairy, and Veterinary Science Faculty Publications

A series of germanium- or silicon-centred heteropolytungstates (polyoxometalates) with the Barrel, Keggin or double Keggin structure were evaluated in vitro for their effects against influenza A (IV-A) and B (IV-B) viruses. Their 50% effective concen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1459::30234a0e6dac4d43890e25fd5abd1ad3
https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=1558&context=advs_facpub

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Akademický článek

EFFECT OF RIBAVIRIN ON TYPE 2 HERPESVIRUS HOMINIS (HVH/2) IN VITRO AND IN VIVO.

Autor: Allen, L. B., Wolf, S. M., Hintz, C. J., Huffman, J. H., Sidwell, R. W.

Publikováno v: Annals of the New York Academy of Sciences; 1977, Vol. 284 Issue 1, p247-253, 7p

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