Výsledky vyhledávání - "Sidsel Frølund"

In vivo and In vitro Evaluations of Intestinal Gabapentin Absorption: Effect of Dose and Inhibitors on Carrier-Mediated Transport

Autor: Malte Selch Larsen, Martha Kampp Nøhr, René Holm, Carsten Uhd Nielsen, Sidsel Frølund, Mats Garmer, Mads Kreilgaard

Publikováno v: Pharmaceutical Research. 32:898-909

Gabapentin exhibits saturable absorption kinetics, however, it remains unclear which transporters that are involved in the intestinal transport of gabapentin. Thus, the aim of the current study was to explore the mechanistic influence of transporters

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d42ee39a36642c25acee0cdbe1cded
https://doi.org/10.1007/s11095-014-1505-1

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Pharmacokinetic aspects of the anti-epileptic drug substance vigabatrin: focus on transporter interactions

Autor: Sidsel Frølund, René Holm, Martha Kampp Nøhr, Carsten Uhd Nielsen

Publikováno v: Therapeutic Delivery. 5:927-942

Drug transporters in various tissues, such as intestine, kidney, liver and brain, are recognized as important mediators of absorption, distribution, metabolism and excretion of drug substances. This review gives a current status on the transporter(s)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9f325a2ca1f66fcd026768e6f58bcb
https://doi.org/10.4155/tde.14.55

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The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics

Autor: Birger Brodin, Sidsel Frølund, Carsten Uhd Nielsen, René Holm

Publikováno v: British Journal of Pharmacology. 161:589-600

BACKGROUND AND PURPOSE The intestinal proton-coupled amino acid transporter, SLC36A1, transports zwitterionic α-amino acids and drugs such as vigabatrin, gaboxadol and δ-aminolevulinic acid. We hypothesize that SLC36A1 might also transport some dip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::220ca97333308c61267be28130a1a7d0
https://doi.org/10.1111/j.1476-5381.2010.00888.x

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δ-Aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1)

Autor: Carsten Uhd Nielsen, Sidsel Frølund, Oriol Cutillas Marquez, Mie Larsen, Birger Brodin

Publikováno v: British Journal of Pharmacology. 159:1339-1353

Background and purpose: δ-Aminolevulinic acid (ALA) is used in cancer patients for photodynamic diagnosis or therapy. Oral administration of ALA has been used in patients with prostate and bladder cancer. The present aim was to investigate the mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::032e980a6b8c1ec9e8107dfb74104d96
https://doi.org/10.1111/j.1476-5381.2009.00620.x

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Intestinal drug transport via the proton-coupled amino acid transporter PAT1 (SLC36A1) is inhibited by Gly-X(aa) dipeptides

Autor: Sidsel Frølund, René Holm, Louise Langthaler, Carsten Uhd Nielsen, Morten A. Kall

Publikováno v: Molecular pharmaceutics. 9(9)

The oral absorption of some drug substances is mediated by nutrient transporters. As a consequence, nutrients and drugs may compete for available transporters, and interactions at the level of intestinal absorption are possible. Recently, we have ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fe63b38b03a5cbd380c6a4383b64ba
https://pubmed.ncbi.nlm.nih.gov/22853447

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Synthesis and biological activity of argiotoxin 636 and analogues: selective antagonists for ionotropic glutamate receptors

Autor: Anders S. Kristensen, Kristian Strømgaard, Jared K. Nelson, Dennis B. Tikhonov, Sidsel Frølund

Publikováno v: Angewandte Chemie (International ed. in English). 48(17)

More discerning than the parent: Analogues of the polyamine toxin argiotoxin 636 (shown docked in the ion channel of an ionotropic glutamate (iGlu) receptor; N blue, O red) distinguish subtypes of iGlu receptors. Depending on which of the two interna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1843951708a66420c69237b205cec2f
https://pubmed.ncbi.nlm.nih.gov/19152392

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Inside Cover: Synthesis and Biological Activity of Argiotoxin 636 and Analogues: Selective Antagonists for Ionotropic Glutamate Receptors (Angew. Chem. Int. Ed. 17/2009)

Autor: Sidsel Frølund, Jared K. Nelson, Dennis B. Tikhonov, Anders S. Kristensen, Kristian Strømgaard

Publikováno v: Angewandte Chemie International Edition. 48:2994-2994

Spiders of the genus Argiope, such as Argiope lobata, contain polyamine toxins that are potent but nonselective blockers of glutamate receptors. However, by very subtle modifications of the structure of native toxins, it is possible to obtain selecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::391872a3f0e29a54cd3566c0b33ed619
https://doi.org/10.1002/anie.200990085

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Innentitelbild: Synthesis and Biological Activity of Argiotoxin 636 and Analogues: Selective Antagonists for Ionotropic Glutamate Receptors (Angew. Chem. 17/2009)

Autor: Jared K. Nelson, Dennis B. Tikhonov, Anders S. Kristensen, Kristian Strømgaard, Sidsel Frølund

Publikováno v: Angewandte Chemie. 121:3038-3038

Spinnen der Gattung Argiope beispielsweise die Argiope lobata, setzen giftige Polyamine ein, die Glutamat-Rezeptoren stark, aber nicht selektiv blockieren. Geringfugige Anderungen an der Struktur der nativen Toxine, wie sie K. Stromgaard et al. in ih

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0baea16de9a02614094af6fb8ba2a2a
https://doi.org/10.1002/ange.200990087

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