Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Sidse Ehmsen"'
Autor:
Leena Karimi, Carla L. Alves, Mikkel G. Terp, Martina Tuttolomondo, Neil Portman, Sidse Ehmsen, Lene E. Johansen, Martin Bak, Elgene Lim, Henrik J. Ditzel
Publikováno v:
Cancer Communications, Vol 43, Iss 6, Pp 720-725 (2023)
Externí odkaz:
https://doaj.org/article/6e1f64b76d404c68a6d355c985622504
Autor:
Abeer J. Al-Qasem, Carla L. Alves, Sidse Ehmsen, Martina Tuttolomondo, Mikkel G. Terp, Lene E. Johansen, Henriette Vever, Luna V. A. Hoeg, Daniel Elias, Martin Bak, Henrik J. Ditzel
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-16 (2022)
Abstract Resistance to aromatase inhibitor (AI) treatment and combined CDK4/6 inhibitor (CDK4/6i) and endocrine therapy (ET) are crucial clinical challenges in treating estrogen receptor-positive (ER+) breast cancer. Understanding the resistance mech
Externí odkaz:
https://doaj.org/article/9f1ef5ffbaa6447d89604c247e5ea621
Autor:
Shijun Ma, Yue Zhao, Wee Chyan Lee, Li-Teng Ong, Puay Leng Lee, Zemin Jiang, Gokce Oguz, Zhitong Niu, Min Liu, Jian Yuan Goh, Wenyu Wang, Matias A. Bustos, Sidse Ehmsen, Adaikalavan Ramasamy, Dave S. B. Hoon, Henrik J. Ditzel, Ern Yu Tan, Qingfeng Chen, Qiang Yu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Hypoxia can promote tumor escape from immune surveillance and immunotherapy. Here, the authors show that hypoxia induces T and NK cell dysfunction through HIF1α-mediated epigenetic suppression of effector gene expression, conferring resistance to an
Externí odkaz:
https://doaj.org/article/f4d636bacf6c468fb0de459e001bd7f5
Autor:
Carla L. Alves, Sidse Ehmsen, Mikkel G. Terp, Neil Portman, Martina Tuttolomondo, Odd L. Gammelgaard, Monique F. Hundebøl, Kamila Kaminska, Lene E. Johansen, Martin Bak, Gabriella Honeth, Ana Bosch, Elgene Lim, Henrik J. Ditzel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
CDK4/6 inhibitors in combination with endocrine therapy has shown efficacy in ER + breast cancer patients but resistance can occur. Here, the authors demonstrate that co-targeting CDK4/6 and AKT with endocrine therapy prevents acquired resistance and
Externí odkaz:
https://doaj.org/article/73e69d21bd364412a70101afb76ad7da
Autor:
Kamila Kaminska, Nina Akrap, Johan Staaf, Carla L. Alves, Anna Ehinger, Anna Ebbesson, Ingrid Hedenfalk, Lukas Beumers, Srinivas Veerla, Katja Harbst, Sidse Ehmsen, Signe Borgquist, Åke Borg, Alejandro Pérez-Fidalgo, Henrik J. Ditzel, Ana Bosch, Gabriella Honeth
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-18 (2021)
Abstract Background Resistance to endocrine treatment in metastatic breast cancer is a major clinical challenge. Clinical tools to predict both drug resistance and possible treatment combination approaches to overcome it are lacking. This unmet need
Externí odkaz:
https://doaj.org/article/7cbcb174cf144b08807aab383e525e6b
Autor:
Yi Bao, Gokce Oguz, Wee Chyan Lee, Puay Leng Lee, Kakaly Ghosh, Jiayao Li, Panpan Wang, Peter E. Lobie, Sidse Ehmsen, Henrik J. Ditzel, Andrea Wong, Ern Yu Tan, Soo Chin Lee, Qiang Yu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Resistance to anti-HER2 therapies in breast cancer remains a significant clinical challenge. Here, the authors demonstrate that EZH2 regulates response to HER2-targeting therapies in breast cancer, in part, by modulating the expression of PPP2R2B.
Externí odkaz:
https://doaj.org/article/d3c09063233a46f7b4d0dbd7cf8055f0
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 10053 (2022)
Triple-negative breast cancer (TNBC) is a heterogeneous disease that accounts for 10–15% of all breast cancer cases. Within TNBC, the treatment of basal B is the most challenging due to its highly invasive potential, and thus treatments to suppress
Externí odkaz:
https://doaj.org/article/2db0d0171d1f44699bff5f131e24bde9
Autor:
Annette R. Kodahl, Sidse Ehmsen, Niels Pallisgaard, Anne M. B. Jylling, Jeanette D. Jensen, Anne‐Vibeke Lænkholm, Ann S. Knoop, Henrik J. Ditzel
Publikováno v:
Molecular Oncology, Vol 12, Iss 6, Pp 925-935 (2018)
Liquid biopsies focusing on the analysis of cell‐free circulating tumor DNA (ctDNA) may have important clinical implications for personalized medicine, including early detection of cancer, therapeutic guidance, and monitoring of recurrence. Mutatio
Externí odkaz:
https://doaj.org/article/25c7104ef4c446408cd90a879f5ba181
Autor:
Carla L. Alves, Sidse Ehmsen, Mikkel G. Terp, Neil Portman, Martina Tuttolomondo, Odd L. Gammelgaard, Monique F. Hundebøl, Kamila Kaminska, Lene E. Johansen, Martin Bak, Gabriella Honeth, Ana Bosch, Elgene Lim, Henrik J. Ditzel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/df7e78eab9c643b4bcc917eea8a3ff30
Autor:
Sidse Ehmsen, Martin H. Pedersen, Guisong Wang, Mikkel G. Terp, Amina Arslanagic, Brian L. Hood, Thomas P. Conrads, Rikke Leth-Larsen, Henrik J. Ditzel
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3927-3938.e6 (2019)
Summary: Tumor eradication may be greatly improved by targeting cancer stem cells (CSCs), as they exhibit resistance to conventional therapy. To gain insight into the unique biology of CSCs, we developed patient-derived xenograft tumors (PDXs) from E
Externí odkaz:
https://doaj.org/article/8e8a496aa1f64ed4a56531ee422573a6