Zobrazeno 1 - 10
of 439
pro vyhledávání: '"Sidney M. Hecht"'
Autor:
Indrajit Bandyopadhyay, Sandipan Roy Chowdhury, Nishant P. Visavadiya, Sidney M. Hecht, Omar M. Khdour
Publikováno v:
Data in Brief, Vol 20, Iss , Pp 1105-1114 (2018)
As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significan
Externí odkaz:
https://doaj.org/article/1a4d5774787d4319a4094d8576cd6812
Autor:
Deborah A. Lannigan, Sidney M. Hecht, Timothy M. Errington, Yaming Xu, Celeste E. Poteet-Smith, Jeffrey A. Smith
Supplementary text, 3 figures, and 1 table.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4916dacda5d4f60b74417c59f9d30b97
https://doi.org/10.1158/0008-5472.22333081.v1
https://doi.org/10.1158/0008-5472.22333081.v1
Autor:
Deborah A. Lannigan, Sidney M. Hecht, Timothy M. Errington, Yaming Xu, Celeste E. Poteet-Smith, Jeffrey A. Smith
p90 ribosomal S6 kinase (RSK) is an important downstream effector of mitogen-activated protein kinase, but its biological functions are not well understood. We have now identified the first small-molecule, RSK-specific inhibitor, which we isolated fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05da0ec9a455a3c2692a544a921c2e40
https://doi.org/10.1158/0008-5472.c.6493074
https://doi.org/10.1158/0008-5472.c.6493074
Publikováno v:
ACS chemical biology.
The family of NF-κB transcriptional activators controls the expression of many genes, including those involved in cell survival and development. The family consists of homo- and heterodimers constituted by combinations of five subunits. Subunit p50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8165efc6ed42eeaa1609df670525059d
https://pubmed.ncbi.nlm.nih.gov/36534507
https://pubmed.ncbi.nlm.nih.gov/36534507
Publikováno v:
Chem Commun (Camb)
The NF-κB family of transcriptional activators is responsible for the expression of numerous genes that control key functions such as cell development and survival. Subunit p50 has been studied extensively and is known to include 13 tyrosines, but t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd12975bd2e6fcfa04b3910eff8690b
https://doi.org/10.1039/d1cc04726d
https://doi.org/10.1039/d1cc04726d
Autor:
Adarsh Kumar, Andrew J. Reed, Walter J. Zahurancik, Sasha M. Daskalova, Sidney M. Hecht, Zucai Suo
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Base excision repair (BER) is one of the major DNA repair pathways used to fix a myriad of cellular DNA lesions. The enzymes involved in BER, including DNA polymerase β (Polβ), have been identified and characterized, but how they act t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725549340803b8bd12ee386fa1904e15
https://doi.org/10.1073/pnas.2118940119
https://doi.org/10.1073/pnas.2118940119
Publikováno v:
Biochemistry. 59:1217-1220
The identification of proteins that bind selectively to nucleic acid sequences is an ongoing challenge. We previously synthesized nucleobase amino acids designed to replace proteinogenic amino acids; these were incorporated into proteins to bind spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b111f09eab76257bf3892e423ddd3b6d
https://doi.org/10.1021/acs.biochem.0c00103
https://doi.org/10.1021/acs.biochem.0c00103
Publikováno v:
ACS Infectious Diseases. 5:1907-1914
Dengue virus (DENV) is the most common human arboviral infection worldwide and can present with severe clinical manifestations. Timely DENV detection improves clinical outcomes, and identification of the DENV serotype (DENV-1-4) may provide beneficia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a3edb7f3e69fef29ca1cd51652f990
https://doi.org/10.1021/acsinfecdis.9b00241
https://doi.org/10.1021/acsinfecdis.9b00241
Publikováno v:
Bioorg Med Chem
The elaboration of peptides and proteins containing non-proteinogenic amino acids has been realized using several complementary strategies, including chemical synthesis, ribosome- or non-ribosome-mediated elaboration, intein-mediated polypeptide rear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116070698acdb8823efd8aa1c670c640
https://europepmc.org/articles/PMC8217302/
https://europepmc.org/articles/PMC8217302/
Autor:
Sidney M. Hecht
Publikováno v:
J Mol Biol
Biological protein synthesis is mediated by the ribosome, and employs ~20 proteinogenic amino acids as building blocks. Through the use of misacylated tRNAs, presently accessible by any of several strategies, it is now possible to employ in vitro and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106eb60bb8bf7e7b8112b872cdef4bab
https://doi.org/10.1016/j.jmb.2021.167211
https://doi.org/10.1016/j.jmb.2021.167211