Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Sidney M Morris"'
Autor:
Boris L Vaisman, Karen L Andrews, Sacha M L Khong, Katherine C Wood, Xiao L Moore, Yi Fu, Diane M Kepka-Lenhart, Sidney M Morris, Alan T Remaley, Jaye P F Chin-Dusting
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39487 (2012)
Cardiovascular disorders associated with endothelial dysfunction, such as atherosclerosis, have decreased nitric oxide (NO) bioavailability. Arginase in the vasculature can compete with eNOS for L-arginine and has been implicated in atherosclerosis.
Externí odkaz:
https://doaj.org/article/1cb143279c0f4aa0b02731cf0b25b08a
Autor:
Aaron Erdely, Diane Kepka-Lenhart, Rebecca Salmen-Muniz, Rebecca Chapman, Tracy Hulderman, Michael Kashon, Petia P Simeonova, Sidney M Morris
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15253 (2010)
Increased catabolism of arginine by arginase is increasingly viewed as an important pathophysiological factor in cardiovascular disease, including atherosclerosis induced by high cholesterol diets. Whereas previous studies have focused primarily on e
Externí odkaz:
https://doaj.org/article/b2109f69e19940a980124f78779c1f2a
Autor:
Kristen Stanley, Michael D. Wetzel, Ting Gao, Timothy K. Cooper, Alaa S. Awad, Sidney M. Morris
Publikováno v:
Am J Physiol Renal Physiol
Endothelial dysfunction, characterized by reduced bioavailability of nitric oxide and increased oxidative stress, is a hallmark characteristic in diabetes and diabetic nephropathy (DN). High levels of asymmetric dimethylarginine (ADMA) are observed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b868f44a9906174b16091b1a2657f86
https://doi.org/10.1152/ajprenal.00518.2019
https://doi.org/10.1152/ajprenal.00518.2019
Publikováno v:
American Journal of Physiology-Renal Physiology. 313:F899-F905
Diabetes is the leading cause of end-stage renal disease, resulting in a significant health care burden and loss of economic productivity by affected individuals. Because current therapies for progression of diabetic nephropathy (DN) are only moderat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d508d3cb0d9dc56bf7cf9e3fc87aaec
https://doi.org/10.1152/ajprenal.00158.2017
https://doi.org/10.1152/ajprenal.00158.2017
Autor:
Wesley M. Raup-Konsavage, Timothy K. Cooper, Sidney M. Morris, W. Brian Reeves, Ting Gao, Alaa S. Awad
Publikováno v:
American Journal of Physiology-Renal Physiology. 313:F522-F534
Novel therapeutic interventions for preventing or attenuating kidney injury following ischemia-reperfusion injury (IRI) remain a focus of significant interest. Currently, there are no definitive therapeutic or preventive approaches available for isch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb5de5da08980fcf5d8a143d3a41d67
https://doi.org/10.1152/ajprenal.00620.2016
https://doi.org/10.1152/ajprenal.00620.2016
Autor:
Patrick J. Stover, Rajavel Elango, Motoni Kadowaki, Dennis M. Bier, Miro Smriga, Sidney M. Morris, Luc Cynober
Publikováno v:
The Journal of nutrition. 150(Suppl 1)
Based on research presented during the 10th Amino Acid Assessment Workshop, no observed adverse effect levels (NOAELs) for supplemental methionine at 46 mg/(kg·d) (∼3.2 g/d), for supplemental histidine at 8.0 g/d, and for supplemental lysine at 6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2867d418368ddcca67630f52a75d4c03
https://pubmed.ncbi.nlm.nih.gov/33000163
https://pubmed.ncbi.nlm.nih.gov/33000163
Publikováno v:
Physiological Reports, Vol 7, Iss 18, Pp n/a-n/a (2019)
Physiological Reports
Physiological Reports
l‐homoarginine is an endogenous, non‐proteinogenic amino acid that has emerged as a new player in health and disease. Specifically, low l‐homoarginine levels are associated with cardiovascular diseases, stroke, and reduced kidney function. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d636526997f22d8202d3fe52c9bbb820
https://doaj.org/article/70c13744244046ab95a47ffc6ed3d68d
https://doaj.org/article/70c13744244046ab95a47ffc6ed3d68d
Autor:
Sidney M. Morris
Publikováno v:
The Journal of Nutrition. 146:2579S-2586S
Mammalian arginine metabolism is complex due to the expression of multiple enzymes that utilize arginine as substrate and to interactions or competition between specific enzymes involved in arginine metabolism. Moreover, cells may contain multiple in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9ba29ce16e32106ff25890dbe11d4a
https://doi.org/10.3945/jn.115.226621
https://doi.org/10.3945/jn.115.226621
Autor:
Zhi Ping Liu, Robert Luo, Joseph A. Hill, Zhaoning Wang, Jay W. Schneider, Sean C. Goetsch, Sidney M. Morris, Min Zhu
Publikováno v:
Circulation Research. 117:967-977
Rationale: Inflammation in post–myocardial infarction (MI) is necessary for myocyte repair and wound healing. Unfortunately, it is also a key component of subsequent heart failure pathology. Transcription factor forkhead box O4 (FoxO4) regulates a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e5fa6ff85902294d0f7449152ce576
https://doi.org/10.1161/circresaha.115.306919
https://doi.org/10.1161/circresaha.115.306919
Publikováno v:
American Journal of Physiology-Renal Physiology. 309:F447-F455
Our previous publication showed that inhibition of arginase prevents the development of diabetic nephropathy (DN). However, identification of targets that retard the progression of established DN–which is more clinically relevant–is lacking. Ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21763f18ee4b75c9506a63e0f65c6f27
https://doi.org/10.1152/ajprenal.00137.2015
https://doi.org/10.1152/ajprenal.00137.2015