Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sidney Chan"'
Autor:
Buwei Huang, Brian Coventry, Marta T. Borowska, Dimitrios C. Arhontoulis, Marc Exposit, Mohamad Abedi, Kevin M. Jude, Samer F. Halabiya, Aza Allen, Cami Cordray, Inna Goreshnik, Maggie Ahlrichs, Sidney Chan, Hillary Tunggal, Michelle DeWitt, Nathaniel Hyams, Lauren Carter, Lance Stewart, Deborah H. Fuller, Ying Mei, K. Christopher Garcia, David Baker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Cytokine release syndrome (CRS), commonly known as cytokine storm, is an acute systemic inflammatory response that is a significant global health threat. Interleukin-6 (IL-6) and interleukin-1 (IL-1) are key pro-inflammatory cytokines involv
Externí odkaz:
https://doaj.org/article/5f93a3f590e5444ea2f8d8872b6aedb3
Autor:
Daniel Ellis, Annie Dosey, Seyhan Boyoglu-Barnum, Young-Jun Park, Rebecca Gillespie, Hubza Syeda, Geoffrey B. Hutchinson, Yaroslav Tsybovsky, Michael Murphy, Deleah Pettie, Nick Matheson, Sidney Chan, George Ueda, Jorge A. Fallas, Lauren Carter, Barney S. Graham, David Veesler, Masaru Kanekiyo, Neil P. King
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113552- (2023)
Summary: Immunogen design approaches aim to control the specificity and quality of antibody responses elicited by next-generation vaccines. Here, we use computational protein design to generate a nanoparticle vaccine platform based on the receptor-bi
Externí odkaz:
https://doaj.org/article/f0b10a69337b4749a61aac233ea0c282
Autor:
Daniel Ellis, Julia Lederhofer, Oliver J. Acton, Yaroslav Tsybovsky, Sally Kephart, Christina Yap, Rebecca A. Gillespie, Adrian Creanga, Audrey Olshefsky, Tyler Stephens, Deleah Pettie, Michael Murphy, Claire Sydeman, Maggie Ahlrichs, Sidney Chan, Andrew J. Borst, Young-Jun Park, Kelly K. Lee, Barney S. Graham, David Veesler, Neil P. King, Masaru Kanekiyo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Influenza virus neuraminidase (NA) is a drug target and a potential vaccine antigen. Here, the authors provide a detailed analysis of the conformational stability of NA, and show how expression and stability of recombinant NA antigens can be strength
Externí odkaz:
https://doaj.org/article/e57f3c320a9b4bb08e43192a409483e7
Autor:
Timothy Quy-Phong Do, Stuart Grayson MacKay, Matthew Eugene Lam, Anders William Sideris, Andrew Christopher Jones, Lyndon Sidney Chan
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
PurposeTo assess the validity of home sleep apnea test directed diagnosis and treatment of obstructive sleep apnea (OSA) in a real-life clinical setting and establish the extent to which clinical evaluation alters diagnosis and therapeutic interventi
Externí odkaz:
https://doaj.org/article/fff0ec98fe0f4e8aa14e1acac6fb88d0
Autor:
Erin C. Yang, Robby Divine, Christine S. Kang, Sidney Chan, Elijah Arenas, Zoe Subol, Peter Tinker, Hayden Manninen, Alicia Feichtenbiner, Talal Mustafa, Julia Hallowell, Isiac Orr, Hugh Haddox, Brian Koepnick, Jacob O’Connor, Ian C. Haydon, Karla-Luise Herpoldt, Kandise Van Wormer, Celine Abell, David Baker, Alena Khmelinskaia, Neil P. King
Publikováno v:
Journal of Chemical Education. 99:3177-3186
Undergraduate research experiences can improve student success in graduate education and STEM careers. During the COVID-19 pandemic, undergraduate researchers at our institution and many others lost their work-study research positions due to interrup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39487fbe1833e5033efd9c03e726df49
https://doi.org/10.1021/acs.jchemed.2c00500
https://doi.org/10.1021/acs.jchemed.2c00500
Autor:
Dilip Kumar Agarwal, Andrew C. Hunt, Gajendra S. Shekhawat, Lauren Carter, Sidney Chan, Kejia Wu, Longxing Cao, David Baker, Ramon Lorenzo-Redondo, Egon A. Ozer, Lacy M. Simons, Judd F. Hultquist, Michael C. Jewett, Vinayak P. Dravid
Publikováno v:
Analytical Chemistry. 94:8105-8109
New platforms for the rapid and sensitive detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern are urgently needed. Here we report the development of a nanomechanical sensor based on the deflection of a microc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4458919149a25545b6166f464622e31
https://doi.org/10.1021/acs.analchem.2c01221
https://doi.org/10.1021/acs.analchem.2c01221
Autor:
Erin C. Yang, Robby Divine, Marcos C. Miranda, Andrew J. Borst, Will Sheffler, Jason Z Zhang, Justin Decarreau, Amijai Saragovi, Mohamad Abedi, Nicolas Goldbach, Maggie Ahlrichs, Craig Dobbins, Alexis Hand, Suna Cheng, Mila Lamb, Paul M. Levine, Sidney Chan, Rebecca Skotheim, Jorge Fallas, George Ueda, Joshua Lubner, Masaharu Somiya, Alena Khmelinskaia, Neil P. King, David Baker
Publikováno v:
bioRxiv
Programming protein nanomaterials to respond to changes in environmental conditions is a current challenge for protein design and important for targeted delivery of biologics. We describe the design of octahedral non-porous nanoparticles with the thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08485ba26a36e4b67dd39fd83b59e0cd
https://doi.org/10.1101/2023.04.17.537263
https://doi.org/10.1101/2023.04.17.537263
Autor:
Jing Yang (John) Wang, Alena Khmelinskaia, William Sheffler, Marcos C. Miranda, Aleksandar Antanasijevic, Andrew J. Borst, Susana V. Torres, Chelsea Shu, Yang Hsia, Una Nattermann, Daniel Ellis, Carl Walkey, Maggie Ahlrichs, Sidney Chan, Alex Kang, Hannah Nguyen, Claire Sydeman, Banumathi Sankaran, Mengyu Wu, Asim K. Bera, Lauren Carter, Brooke Fiala, Michael Murphy, David Baker, Andrew B. Ward, Neil P. King
Computationally designed protein nanoparticles have recently emerged as a promising platform for the development of new vaccines and biologics. For many applications, secretion of designed nanoparticles from eukaryotic cells would be advantageous, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115c7abbdfb14cb721d89bac11eda22f
https://doi.org/10.1101/2022.08.04.502842
https://doi.org/10.1101/2022.08.04.502842
Autor:
Timothy Quy-Phong Do, Stuart Grayson MacKay, Matthew Eugene Lam, Anders William Sideris, Andrew Christopher Jones, Lyndon Sidney Chan
Publikováno v:
Frontiers in neurology. 13
PurposeTo assess the validity of home sleep apnea test directed diagnosis and treatment of obstructive sleep apnea (OSA) in a real-life clinical setting and establish the extent to which clinical evaluation alters diagnosis and therapeutic interventi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8572def23d5fabba608211e111d7a9
https://pubmed.ncbi.nlm.nih.gov/35265029
https://pubmed.ncbi.nlm.nih.gov/35265029
Autor:
Daniel Ellis, Julia Lederhofer, Oliver J. Acton, Yaroslav Tsybovsky, Sally Kephart, Christina Yap, Rebecca A. Gillespie, Adrian Creanga, Audrey Olshefsky, Tyler Stephens, Deleah Pettie, Michael Murphy, Claire Sydeman, Maggie Ahlrichs, Sidney Chan, Andrew J. Borst, Young-Jun Park, Kelly K. Lee, Barney S. Graham, David Veesler, Neil P. King, Masaru Kanekiyo
Publikováno v:
Nature communications. 13(1)
Influenza virus neuraminidase (NA) is a major antiviral drug target and has recently reemerged as a key target of antibody-mediated protective immunity. Here we show that recombinant NAs across non-bat subtypes adopt various tetrameric conformations,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbce2f01d241af84b4da6be1fbbfbf0
https://pubmed.ncbi.nlm.nih.gov/35383176
https://pubmed.ncbi.nlm.nih.gov/35383176