Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Sidney D. Nelson"'
Autor:
Isaac Mohar, Brendan D. Stamper, Peter M. Rademacher, Collin C. White, Sidney D. Nelson, Terrance J. Kavanagh
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 377-387 (2014)
The mechanism by which acetaminophen (APAP) causes liver damage evokes many aspects drug metabolism, oxidative chemistry, and genetic-predisposition. In this study, we leverage the relative resistance of female C57BL/6 mice to APAP-induced liver dama
Externí odkaz:
https://doaj.org/article/4a4c70ebc1494997ba14a87ad8ef85b1
Publikováno v:
Clinical and Experimental Dermatology. 45:134-136
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71db321e9c3def438cbfb0f0eaedf2b
https://doi.org/10.1111/ced.14033
https://doi.org/10.1111/ced.14033
Autor:
Sidney D. Nelson
Publikováno v:
Drug-Drug Interactions ISBN: 9780429131967
This chapter focuses on those metabolic drug-drug interactions that have led or can lead to serious toxicological consequences in humans. It describes examples of metabolic drug-drug interactions that have caused serious toxicities. General aspects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40af35050d3eac7a559eba2789a0f5d8
https://doi.org/10.1201/9780429131967-17
https://doi.org/10.1201/9780429131967-17
Autor:
Brendan D. Stamper, Michael L. Garcia, Duy Q. Nguyen, Richard P. Beyer, Theo K. Bammler, Frederico M. Farin, Terrance J. Kavanagh, Sidney D. Nelson
Publikováno v:
Gene Regulation and Systems Biology, Vol 2015, Iss 9, Pp 1-14 (2015)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::faad50b7943decab4f5dcfb836b70c92
http://www.la-press.com/p53-contributes-to-differentiating-gene-expression-following-exposure--article-a4874
http://www.la-press.com/p53-contributes-to-differentiating-gene-expression-following-exposure--article-a4874
Autor:
Ioannis Papageorgiou, Michelle D. Wahlin, Jashvant D. Unadkat, Sidney D. Nelson, Klarissa D. Hardy, Allan E. Rettie
Publikováno v:
Drug Metabolism and Disposition. 42:162-171
Idiosyncratic hepatotoxicity has been associated with the oral tyrosine kinase inhibitor lapatinib, which is used in metastatic breast cancer therapy. Lapatinib is extensively metabolized by cytochrome P450 3A4/5 to yield an O-debenzylated metabolite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0efc0e4ad2ff5429e3574c9ae0dbfa
https://doi.org/10.1124/dmd.113.054817
https://doi.org/10.1124/dmd.113.054817
Autor:
Hirdesh Uppal, Dylan P. Hartley, Shimako Oishi, Kevin A. Ford, S. Cyrus Khojasteh, Sidney D. Nelson
Publikováno v:
Chemical Research in Toxicology. 25:2301-2309
Pulegone is the major constituent of pennyroyal oil, a folkloric abortifacient that is associated with hepatotoxicity and, in severe cases, death. Cytochrome P450-mediated oxidation of pulegone generates menthofuran, which is further oxidized to form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25601e912a32e81c69178ce4e0341bb0
https://doi.org/10.1021/tx300144d
https://doi.org/10.1021/tx300144d
Publikováno v:
Drug Metabolism and Disposition. 40:1460-1465
The hypothesis that N-acetyl-m-aminophenol (AMAP), the meta isomer of acetaminophen, will covalently bind to and inhibit human CYP2E1 in a time- and NADPH-dependent manner was investigated. Liquid chromatography/electrospray ionization-mass spectrome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb3c40b6021aa9018a700c63f87ea10a
https://doi.org/10.1124/dmd.112.045492
https://doi.org/10.1124/dmd.112.045492
Autor:
Eric Chun Yong Chan, Sidney D. Nelson, Chun Wei Yap, Teck Beng Chua, Han Kiat Ho, Lee Sun New
Publikováno v:
Drug Metabolism and Disposition. 40:1414-1422
Lapatinib, an oral tyrosine kinase inhibitor used for breast cancer, has been reported to cause idiosyncratic hepatotoxicity. Recently, it has been found that lapatinib forms a metabolite-inhibitor complex (MIC) with CYP3A4 via the formation of an al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a65422bef63083f0c9f9e1f0365c336
https://doi.org/10.1124/dmd.112.044958
https://doi.org/10.1124/dmd.112.044958
Autor:
Hideo Takakusa, Edward J. Kelly, Terrance J. Kavanagh, Isaac Mohar, Sidney D. Nelson, Rüdiger Kaspera
Publikováno v:
Biochemical and Biophysical Research Communications. 420:54-60
Mitochondria are the primary locus for the generation of reactive nitrogen species including peroxynitrite and subsequent protein tyrosine nitration. Protein tyrosine nitration may have important functional and biological consequences such as alterat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b7036e57c460051e83bc7716fa0865
https://doi.org/10.1016/j.bbrc.2012.02.114
https://doi.org/10.1016/j.bbrc.2012.02.114
Autor:
Thomas A. Baillie, Zhican Wang, Takanori Hashizume, Mary F. Hebert, Yvonne S. Lin, David K. Blough, Leslie J. Dickmann, Sidney D. Nelson, Connie L. Davis, Tauri Senn, Michele Scian, Kenneth E. Thummel, Xi Emily Zheng
Publikováno v:
Molecular Pharmacology. 81:498-509
Vitamin D(3) is critical for the regulation of calcium and phosphate homeostasis. In some individuals, mineral homeostasis can be disrupted by long-term therapy with certain antiepileptic drugs and the antimicrobial agent rifampin, resulting in drug-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a5138c678e1002309b31228929c416
https://doi.org/10.1124/mol.111.076356
https://doi.org/10.1124/mol.111.076356