Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sidhartha Tulachan"'
Autor:
Chiyo Shiota, Shane Fischbach, Krishna Prasadan, Xiangwei Xiao, Christopher Rymer, John Wiersch, Zewen Song, Ping Guo, Yousef El-Gohary, Iljana Gaffar, George K. Gittes, Farzad Esni, Sidhartha Tulachan, Csaba Galambos
Publikováno v:
Endocrinology. 157:166-175
A key question in diabetes research is whether new β-cells can be derived from endogenous, nonendocrine cells. The potential for pancreatic ductal cells to convert into β-cells is a highly debated issue. To date, it remains unclear what anatomical
Autor:
George K. Gittes, John Wiersch, Yousef El-Gohary, Chiyo Shiota, Prasadan Krishna, Sidhartha Tulachan, Barry Preuett, Xiangwei Xiao, Iliana Gaffar, Ping Guo, Zewen Song
Publikováno v:
Mechanisms of Development. 134:67-79
Tight spatial regulation of extracellular morphogen signaling within the close confines of a developing embryo is critical for proper organogenesis. Given the complexity of extracellular signaling in developing organs, together with the proximity of
Autor:
Yousef El-Gohary, Krishna Prasadan, Jose Paredes, Chiyo Shiota, George K. Gittes, John Wiersch, Yoko Wada, P. Guo, Sidhartha Tulachan, Marilyn Diaz, Xiangwei Xiao, Carey Welsh
Publikováno v:
Diabetes
Pancreatic β-cell loss and dysfunction are critical components of all types of diabetes. Human and rodent β-cells are able to proliferate, and this proliferation is an important defense against the evolution and progression of diabetes. Transformin
Autor:
Jose Paredes, Xiangwei Xiao, John Wiersch, Krishna Prasadan, Yousef El-Gohary, Sidhartha Tulachan, Chiyo Shiota, Ping Guo, George K. Gittes
Publikováno v:
Journal of Virological Methods. 183:139-146
Preclinical gene therapy studies both in-vitro and in-vivo require high purity preparations of adeno-associated virus (AAV). Current methods for purification of AAV entail the use of centrifugation over either a CsCl or iodixanol gradient, or the use
Autor:
Krishna Prasadan, George K. Gittes, Jose Paredes, Sidhartha Tulachan, N. Lath, Sunder Sims-Lucas, Yousef El-Gohary, Chiyo Shiota, Xiangwei Xiao, John Wiersch, Ping Guo, Carey Welsh
Publikováno v:
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology. 295:1473-1481
The pancreatic islets of Langerhans are highly vascularized structures scattered throughout the pancreas that contain a capillary network 5-10 times denser than that of the exocrine pancreas. A simple method for three-dimensional (3D) analysis of thi
Autor:
Yousef El-Gohary, Sunder Sims-Lucas, Krishna Prasadan, George K. Gittes, Maria F. Branca, Chiyo Shiota, Ping Guo, Sidhartha Tulachan
Publikováno v:
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology. 295:465-473
Confocal microscopy in combination with commercial software is frequently used to generate three-dimensional images of tissue architecture. Here we report a novel, whole-mount imaging protocol technique that allows detailed three-dimensional imaging
Autor:
Sohail R. Shah, Marcus M. Malek, Ping Guo, David J. Hackam, George K. Gittes, Jose Paredes, Pier G. Mastroberardino, Sidhartha Tulachan, Chiyo Shiota, Adam Jakub, Krishna Prasadan, Farzad Esni, Douglas A. Potoka, R. Cartland Burns, Nikesh Lath, Kelly A. Miller
Publikováno v:
Developmental Biology. 349(2):342-349
The mammalian embryo represents a fundamental paradox in biology. Its location within the uterus, especially early during development when embryonic cardiovascular development and placental blood flow are not well-established, leads to an obligate hy
Autor:
Masayuki Koizumi, Sidhartha Tulachan, Nikesh Lath, Ping Guo, Marcus M. Malek, Yousef El-Gohary, George K. Gittes, Chiyo Shiota, Jose Paredes, Sohail R. Shah, Krishna Prasadan
Publikováno v:
Diabetes
OBJECTIVE Glucose-dependent insulinotropic polypeptide (GIP) is a member of a structurally related group of hormones that also includes glucagon, glucagon-like peptides, and secretin. GIP is an incretin, known to modulate glucose-induced insulin secr
Autor:
Ping Guo, Masayuki Koizumi, Eri Tei, Christopher A. Crisera, Sohail R. Shah, Sidhartha Tulachan, Krishna Prasadan, Erwin P. Bottinger, George K. Gittes, Mark Hembree
Publikováno v:
Developmental Biology. 305:508-521
Transforming growth factor-beta (TGF-beta) superfamily signaling has been implicated in many developmental processes, including pancreatic development. Previous studies are conflicting with regard to an exact role for TGF-beta signaling in various as