Výsledky vyhledávání - "Siderovski, D P"

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Regulators of G-Protein Signaling and Their G Substrates: Promises and Challenges in Their Use as Drug Discovery Targets

Autor: Giguere, P. M., Bosch, D. E., Kimple, A. J., Siderovski, D. P.

Because G-protein coupled receptors (GPCRs) continue to represent excellent targets for the discovery and development of small-molecule therapeutics, it is posited that additional protein components of the signal transduction pathways emanating from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28c2e09708afce1eae571bbe09da976e

Zobrazit plný text záznamu

2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids

Autor: King, E. M., Holden, N. S., Rider, C. F., Siderovski, D. P., Gaunt, D. D., Bell, M. J., Heximer, S. P., Newton, R., Leigh, R., Giembycz, M. A., Johnson, M.

In asthma and chronic obstructive pulmonary disease, activation of Gq-protein–coupled receptors causes bronchoconstriction. In each case, the management of moderate-to-severe disease uses inhaled corticosteroid (glucocorticoid)/long-acting β2-adre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d1654b19ce45a6c86682a74bea29390

Zobrazit plný text záznamu

Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity

Autor: Willard, F. S., Siderovski, D. P., Kimple, A. J., Kuravi, S., Lambert, N. A., Johnston, C. A., Cappell, S. D.

G-protein heterotrimers, composed of a guanine nucleotide-binding Gα subunit and an obligate Gβγ dimer, regulate signal transduction pathways by cycling between GDP- and GTP-bound states. Signal deactivation is achieved by Gα-mediated GTP hydroly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a639315b6fbda1718758150bd8a8f06f

Zobrazit plný text záznamu

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein -subunits

Autor: Turnbull, A. P., Kimple, A. J., Siderovski, D. P., Fedorov, O. Y., Doyle, D. A., Schoch, G. A., Sundstrom, M., Ball, L. J., Hutsell, S. Q., Dowler, E. F., Willard, F. S., Higman, V. A., Soundararajan, M., Gileadi, C.

Regulator of G protein signaling (RGS) proteins accelerate GTP hydrolysis by Gα subunits and thus facilitate termination of signaling initiated by G protein-coupled receptors (GPCRs). RGS proteins hold great promise as disease intervention points, g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d98607ec83bcacfaa01cce603290047c

Zobrazit plný text záznamu

GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling

Autor: Chen, J.-G., Willard, F. S., Jones, A. M., Kimple, A. J., Grigston, J. C., Johnston, C. A., Taylor, J. P., Gao, Y., Siderovski, D. P.

Heterotrimeric G protein signaling is important for cell-proliferative and glucose-sensing signal transduction pathways in the model plant organism Arabidopsis thaliana. AtRGS1 is a seven-transmembrane, RGS domain-containing protein that is a putativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea7bc7865cbd12fae0bcd555c233161a

Zobrazit plný text záznamu

Clathrin Adaptor AP2 Regulates Thrombin Receptor Constitutive Internalization and Endothelial Cell Resensitization

Autor: Siderovski, D. P., Trejo, J., Paing, M. M., Johnston, C. A.

Protease-activated receptor 1 (PAR1), a G protein-coupled receptor for the coagulant protease thrombin, is irreversibly activated by proteolysis. Unactivated PAR1 cycles constitutively between the plasma membrane and intracellular stores, thereby pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1204c96d108ab1fdd3f174dd117dcd4b

Zobrazit plný text záznamu

Genome-Scale Analysis Reveals Sst2 as the Principal Regulator of Mating Pheromone Signaling in the Yeast Saccharomyces cerevisiae

Autor: Siderovski, D. P., Dohlman, H. G., Parnell, S. C., Flanary, P., Hao, N., Cha, J. Y., Chasse, S. A.

A common property of G protein-coupled receptors is that they become less responsive with prolonged stimulation. Regulators of G protein signaling (RGS proteins) are well known to accelerate G protein GTPase activity and do so by stabilizing the tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c13051f53603fd6e27b138cd25536d1a

Zobrazit plný text záznamu

Leukemia-Associated Rho Guanine Nucleotide Exchange Factor Promotes G q-Coupled Activation of RhoA

Autor: Der, C. J., Booden, M. A., Siderovski, D. P.

Leukemia-associated Rho guanine-nucleotide exchange factor (LARG) belongs to the subfamily of Dbl homology RhoGEF proteins (including p115 RhoGEF and PDZ-RhoGEF) that possess amino-terminal regulator of G protein signaling (RGS) boxes also found with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ff8789af79c1c8f72d1df667a942b96

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání