Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Siddhita D. Mhatre"'
Autor:
Marissa Burke, Kelly Wong, Yuli Talyansky, Siddhita D. Mhatre, Carol Mitchell, Cassandra M. Juran, Makaila Olson, Janani Iyer, Stephanie Puukila, Candice G. T. Tahimic, Lane K. Christenson, Moniece Lowe, Linda Rubinstein, Yasaman Shirazi-Fard, Marianne B. Sowa, Joshua S. Alwood, April E. Ronca, Amber M. Paul
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Exposure to cosmic ionizing radiation is an innate risk of the spaceflight environment that can cause DNA damage and altered cellular function. In astronauts, longitudinal monitoring of physiological systems and interactions between these sy
Externí odkaz:
https://doaj.org/article/a49ceff1b5d94721b1f2bc6e8f711071
Drosophila parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids
Autor:
Jennifer Chou, Johnny R. Ramroop, Amanda M. Saravia-Butler, Brian Wey, Matthew P. Lera, Medaya L. Torres, Mary Ellen Heavner, Janani Iyer, Siddhita D. Mhatre, Sharmila Bhattacharya, Shubha Govind
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108759- (2024)
Summary: While fruit flies (Drosophila melanogaster) and humans exhibit immune system dysfunction in space, studies examining their immune systems’ interactions with natural parasites in space are lacking. Drosophila parasitoid wasps modify blood c
Externí odkaz:
https://doaj.org/article/a629fa82de41491d937df4a70a74b200
Autor:
Joshua S. Alwood, Ajitkumar P. Mulavara, Janani Iyer, Siddhita D. Mhatre, Susanna Rosi, Mark Shelhamer, Catherine Davis, Christopher W. Jones, Xiao Wen Mao, Rajeev I. Desai, Alexandra M. Whitmire, Thomas J. Williams
Publikováno v:
Life, Vol 13, Iss 9, p 1852 (2023)
Biomarkers, ranging from molecules to behavior, can be used to identify thresholds beyond which performance of mission tasks may be compromised and could potentially trigger the activation of countermeasures. Identification of homologous brain region
Externí odkaz:
https://doaj.org/article/fae5ebc0ec5a4b04b825de8bc8b7ab7e
Autor:
Stephanie Puukila, Olivia Siu, Linda Rubinstein, Candice G. T. Tahimic, Moniece Lowe, Steffy Tabares Ruiz, Ivan Korostenskij, Maya Semel, Janani Iyer, Siddhita D. Mhatre, Yasaman Shirazi-Fard, Joshua S. Alwood, Amber M. Paul, April E. Ronca
Publikováno v:
Life, Vol 13, Iss 5, p 1214 (2023)
Exposure to space galactic cosmic radiation is a principal consideration for deep space missions. While the effects of space irradiation on the nervous system are not fully known, studies in animal models have shown that exposure to ionizing radiatio
Externí odkaz:
https://doaj.org/article/783b8f85f80648558e9d9925d3da7f2f
Autor:
Amber M. Paul, Siddhita D. Mhatre, Egle Cekanaviciute, Ann-Sofie Schreurs, Candice G. T. Tahimic, Ruth K. Globus, Sulekha Anand, Brian E. Crucian, Sharmila Bhattacharya
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
A comprehensive understanding of spaceflight factors involved in immune dysfunction and the evaluation of biomarkers to assess in-flight astronaut health are essential goals for NASA. An elevated neutrophil-to-lymphocyte ratio (NLR) is a potential bi
Externí odkaz:
https://doaj.org/article/69eda70fce1841178611ed1a553af5a0
Autor:
Siddhita D. Mhatre, Vivek Satyasi, Mark Killen, Brie E. Paddock, Robert D. Moir, Aleister J. Saunders, Daniel R. Marenda
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 3, Pp 373-385 (2014)
Alzheimer’s disease (AD) is an age-related neurodegenerative disease characterized by memory loss and decreased synaptic function. Advances in transgenic animal models of AD have facilitated our understanding of this disorder, and have aided in the
Externí odkaz:
https://doaj.org/article/c4ad97fcfa7e4458a465841d6ca134e5
Autor:
Ruth K. Globus, Moniece Lowe, Linda Rubinstein, Joshua S. Alwood, Stephanie Puukila, Amber M. Paul, Siddhita D. Mhatre, Candice Tahimic, Janani Iyer, Sharmila Bhattacharya, Marianne B. Sowa, April E. Ronca
Publikováno v:
Neuroscience & Biobehavioral Reviews. 132:908-935
As human space exploration advances to establish a permanent presence beyond the Low Earth Orbit (LEO) with NASA’s Artemis mission, researchers are striving to understand and address the health challenges of living and working in the spaceflight en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66d4be46e4387516c34da027ea7ba53
https://doi.org/10.1016/j.neubiorev.2021.09.055
https://doi.org/10.1016/j.neubiorev.2021.09.055
Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster
Autor:
Siddhita D. Mhatre, Janani Iyer, Juli Petereit, Roberta M. Dolling-Boreham, Anastasia Tyryshkina, Amber M. Paul, Rachel Gilbert, Matthew Jensen, Rebekah J. Woolsey, Sulekha Anand, Marianne B. Sowa, David R. Quilici, Sylvain V. Costes, Santhosh Girirajan, Sharmila Bhattacharya
Publikováno v:
Cell Reports. 40:111279
Spaceflight poses risks to the central nervous system (CNS), and understanding neurological responses is important for future missions. We report CNS changes in Drosophila aboard the International Space Station in response to spaceflight microgravity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e97490280fa11d74258247eed56db9d
https://doi.org/10.1016/j.celrep.2022.111279
https://doi.org/10.1016/j.celrep.2022.111279
Publikováno v:
Neuroscience and biobehavioral reviews. 142
NASA is planning to resume human-crewed lunar missions and lay the foundation for human exploration to Mars. However, our knowledge of the overall effects of long-duration spaceflight on human physiology is limited. During spaceflight, astronauts are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2d1a3338cb3443c8f4701c5fada91d
https://pubmed.ncbi.nlm.nih.gov/36126744
https://pubmed.ncbi.nlm.nih.gov/36126744
Autor:
Edward N. Wilson, Katrin I. Andreasson, Brenna Cholerton, Abigail J. Zuckerman, Frank M. Longo, Qian Wang, Thomas J. Montine, Marian Shahid, Michelle S. Swarovski, Paras S. Minhas, Edward D. Plowey, Patricia Linortner, Kathleen L. Poston, Divya Channappa, Cyrus P. Zabetian, Siddhita D. Mhatre, Joseph F. Quinn, Lu Tian
Publikováno v:
Brain
Parkinson’s disease is the second most common neurodegenerative disease after Alzheimer’s disease and affects 1% of the population above 60 years old. Although Parkinson’s disease commonly manifests with motor symptoms, a majority of patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6629c46b906a14df8dc84b6a200a9a5c
https://europepmc.org/articles/PMC7089668/
https://europepmc.org/articles/PMC7089668/
