Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Siddhesh Aras"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/b1aa4d2f6111438a98b4dd852a68136d
Publikováno v:
Viruses, Vol 15, Iss 12, p 2380 (2023)
Mitochondria have been identified as the “powerhouse” of the cell, generating the cellular energy, ATP, for almost seven decades. Research over time has uncovered a multifaceted role of the mitochondrion in processes such as cellular stress signa
Externí odkaz:
https://doaj.org/article/93497b0594af46a9b3190ddcc2b0ea2a
Autor:
Hussein Chehade, Neeraja Purandare, Alexandra Fox, Nicholas Adzibolosu, Shawn Jayee, Aryan Singh, Roslyn Tedja, Radhika Gogoi, Siddhesh Aras, Lawrence I. Grossman, Gil Mor, Ayesha B. Alvero
Publikováno v:
Translational Oncology, Vol 29, Iss , Pp 101623- (2023)
Cancer progression requires the acquisition of mechanisms that support proliferative potential and metastatic capacity. MNRR1 (also CHCHD2, PARK22, AAG10) is a bi-organellar protein that in the mitochondria can bind to Bcl-xL to enhance its anti-apop
Externí odkaz:
https://doaj.org/article/89a8bc8b63a84bbfb5fbfc3aa920eddc
Autor:
Neeraja Purandare, Yusef Kunji, Yue Xi, Roberto Romero, Nardhy Gomez-Lopez, Andrew Fribley, Lawrence I. Grossman, Siddhesh Aras
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105342- (2022)
Summary: Mitochondria play a key role in placental growth and development, and mitochondrial dysfunction is associated with inflammation in pregnancy pathologies. However, the mechanisms whereby placental mitochondria sense inflammatory signals are u
Externí odkaz:
https://doaj.org/article/4548f7d633da4322b5551fac2a08db3f
Autor:
Kenichiro Motomura, Roberto Romero, Jose Galaz, Li Tao, Valeria Garcia-Flores, Yi Xu, Bogdan Done, Marcia Arenas-Hernandez, Derek Miller, Pedro Gutierrez-Contreras, Marcelo Farias-Jofre, Siddhesh Aras, Lawrence I. Grossman, Adi L. Tarca, Nardhy Gomez-Lopez
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. One of every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by invading bacteria. However, the molecular mechanisms underlying this host
Externí odkaz:
https://doaj.org/article/1adab97a357348e29510437ecaef7b91
Autor:
Harpreet Kaur, Paige Minchella, David Alvarez-Carbonell, Neeraja Purandare, Vijay K. Nagampalli, Daniel Blankenberg, Todd Hulgan, Mariana Gerschenson, Jonathan Karn, Siddhesh Aras, Asha R. Kallianpur
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12242 (2023)
HIV-associated cognitive dysfunction during combination antiretroviral therapy (cART) involves mitochondrial dysfunction, but the impact of contemporary cART on chronic metabolic changes in the brain and in latent HIV infection is unclear. We interro
Externí odkaz:
https://doaj.org/article/2c92077cfce847e5aeeb5e45b0b98d7d
Autor:
Siddhesh Aras, Marie-Claire Maroun, Yeohan Song, Sudeshna Bandyopadhyay, Azadeh Stark, Zeng-Quan Yang, Michael P. Long, Lawrence I. Grossman, Félix Fernández-Madrid
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background Autoantibodies function as markers of tumorigenesis and have been proposed to enhance early detection of malignancies. We recently reported, using immunoscreening of a T7 complementary DNA (cDNA) library of breast cancer (BC) prot
Externí odkaz:
https://doaj.org/article/144c3506bb8e455b8220147e9e2300ff
Publikováno v:
Cells, Vol 10, Iss 2, p 197 (2021)
Oxidative phosphorylation is a tightly regulated process in mammals that takes place in and across the inner mitochondrial membrane and consists of the electron transport chain and ATP synthase. Complex IV, or cytochrome c oxidase (COX), is the termi
Externí odkaz:
https://doaj.org/article/62ddc324c02b4dc3bebef297c16ed2d5
Publikováno v:
PLoS Pathogens, Vol 5, Iss 6, p e1000469 (2009)
Epstein-Barr Nuclear Antigen 1 (EBNA1) is essential for Epstein-Barr virus to immortalize naïve B-cells. Upon binding a cluster of 20 cognate binding-sites termed the family of repeats, EBNA1 transactivates promoters for EBV genes that are required
Externí odkaz:
https://doaj.org/article/92dc5a53f0f240faa6d040d0b9fff230
Publikováno v:
Journal of Applied Genetics. 63:469-474