Zobrazeno 1 - 10
of 360
pro vyhledávání: '"Siddharthan Chandran"'
Autor:
Molly Bowden, Emily Beswick, Johnny Tam, David Perry, Alice Smith, Judy Newton, Siddharthan Chandran, Oliver Watts, Suvankar Pal
Publikováno v:
npj Digital Medicine, Vol 6, Iss 1, Pp 1-19 (2023)
Abstract Motor Neuron Disease (MND) is a progressive and largely fatal neurodegeneritve disorder with a lifetime risk of approximately 1 in 300. At diagnosis, up to 25% of people with MND (pwMND) exhibit bulbar dysfunction. Currently, pwMND are asses
Externí odkaz:
https://doaj.org/article/706d7b30a07643a88e72317fdf893e68
Autor:
Jimmy Beckers, Arun Kumar Tharkeshwar, Laura Fumagalli, Matilde Contardo, Evelien Van Schoor, Raheem Fazal, Dietmar Rudolf Thal, Siddharthan Chandran, Renzo Mancuso, Ludo Van Den Bosch, Philip Van Damme
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-22 (2023)
Abstract Background Motor neurons (MNs), which are primarily affected in amyotrophic lateral sclerosis (ALS), are a specialized type of neurons that are long and non-dividing. Given their unique structure, these cells heavily rely on transport of org
Externí odkaz:
https://doaj.org/article/9ab3bd4af14745a6a8e291ef412cedba
Autor:
Calum Bonthron, Sarah Burley, Matthew J Broadhead, Vanya Metodieva, Seth G N Grant, Siddharthan Chandran, Gareth B Miles
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0306423 (2024)
Hyperexcitability of motor neurons and spinal cord motor circuitry has been widely reported in the early stages of Amyotrophic Lateral Sclerosis (ALS). Changes in the relative amount of excitatory to inhibitory inputs onto a neuron (E:I synaptic rati
Externí odkaz:
https://doaj.org/article/5eddee5f793c4dbe8f33a152d267b332
Autor:
Agniete Kampaite, Rebecka Gustafsson, Elizabeth N York, Peter Foley, Niall J J MacDougall, Mark E Bastin, Siddharthan Chandran, Adam D Waldman, Rozanna Meijboom
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0299634 (2024)
Multiple Sclerosis (MS) is an autoimmune disease affecting the central nervous system, characterised by neuroinflammation and neurodegeneration. Fatigue and depression are common, debilitating, and intertwined symptoms in people with relapsing-remitt
Externí odkaz:
https://doaj.org/article/378b401699af42b2944c3e32da905ce8
Autor:
Erik Nutma, Nurun Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C. Marzin, Robert C. J. Muirhead, Irene Falk, Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper Anink, David Story, Siddharthan Chandran, Jiabin Tang, Maria C. Trolese, Takashi Saito, Takaomi C. Saido, Katharine H. Wiltshire, Paula Beltran-Lobo, Alexandra Phillips, Jack Antel, Luke Healy, Marie-France Dorion, Dylan A. Galloway, Rochelle Y. Benoit, Quentin Amossé, Kelly Ceyzériat, Aurélien M. Badina, Enikö Kövari, Caterina Bendotti, Eleonora Aronica, Carola I. Radulescu, Jia Hui Wong, Anna M. Barron, Amy M. Smith, Samuel J. Barnes, David W. Hampton, Paul van der Valk, Steven Jacobson, Owain W. Howell, David Baker, Markus Kipp, Hannes Kaddatz, Benjamin B. Tournier, Philippe Millet, Paul M. Matthews, Craig S. Moore, Sandra Amor, David R. Owen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quanti
Externí odkaz:
https://doaj.org/article/6e4226618e024c669f4f230499a8801b
Autor:
Irene Molina-Gonzalez, Rebecca K. Holloway, Zoeb Jiwaji, Owen Dando, Sarah A. Kent, Katie Emelianova, Amy F. Lloyd, Lindsey H. Forbes, Ayisha Mahmood, Thomas Skripuletz, Viktoria Gudi, James A. Febery, Jeffrey A. Johnson, Jill H. Fowler, Tanja Kuhlmann, Anna Williams, Siddharthan Chandran, Martin Stangel, Andrew J. M. Howden, Giles E. Hardingham, Veronique E. Miron
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Failed regeneration of myelin around neuronal axons following central nervous system damage contributes to nerve dysfunction and clinical decline in various neurological conditions, for which there is an unmet therapeutic demand. Here, we sh
Externí odkaz:
https://doaj.org/article/c24c9e61819a48939d2ddccda235b862
Autor:
Andrea Salzinger, Vidya Ramesh, Shreya Das Sharma, Siddharthan Chandran, Bhuvaneish Thangaraj Selvaraj
Publikováno v:
Cells, Vol 13, Iss 10, p 792 (2024)
The primary neural circuit affected in Amyotrophic Lateral Sclerosis (ALS) patients is the corticospinal motor circuit, originating in upper motor neurons (UMNs) in the cerebral motor cortex which descend to synapse with the lower motor neurons (LMNs
Externí odkaz:
https://doaj.org/article/70356c62b2f849078d68dac620ceede3
Autor:
Richard A. Parker, Christopher J. Weir, Tra My Pham, Ian R. White, Nigel Stallard, Mahesh K. B. Parmar, Robert J. Swingler, Rachel S. Dakin, Suvankar Pal, Siddharthan Chandran
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background MND-SMART is a platform, multi-arm, multi-stage, multi-centre, randomised controlled trial recruiting people with motor neuron disease. Initially, the treatments memantine and trazodone will each be compared against placebo, but o
Externí odkaz:
https://doaj.org/article/79ee44339d2044749471abb674bbc6f1
Autor:
Thomas Pearson, Yingdi Chen, Baljean Dhillon, Siddharthan Chandran, Jano van Hemert, Tom MacGillivray
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Our purpose was to investigate changes to the retina in multiple sclerosis (MS) using established and novel modes of retinal image acquisition and analysis. 72 participants with MS and 80 healthy volunteers underwent retinal scanning with op
Externí odkaz:
https://doaj.org/article/6f34913cbf764eaba06612d856e243d7
Autor:
Emily Beswick, Suzanne Quigley, Pamela Macdonald, Sarah Patrick, Shuna Colville, Siddharthan Chandran, Peter Connick
Publikováno v:
BMC Psychology, Vol 10, Iss 1, Pp 1-9 (2022)
Abstract Background: Depression has a point prevalence of 25% and lifetime prevalence of 50% in people with multiple sclerosis (pwMS). Due to accessibility and brevity, the 9-item Patient Health Questionnaire (PHQ-9) may be a useful tool in clinical
Externí odkaz:
https://doaj.org/article/e3f99fef2c4646ee90103aa2177b2878