Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Siddhartha Rawat"'
Publikováno v:
Viruses, Vol 4, Iss 11, Pp 2945-2972 (2012)
Worldwide, an estimated 350 million people are chronically infected with the Hepatitis B Virus (HBV); chronic infection with HBV is associated with the development of severe liver diseases including hepatitis and cirrhosis. Individuals who are chroni
Externí odkaz:
https://doaj.org/article/e2766f41758a47b391aba8fd43064f48
Publikováno v:
Micromachines, Vol 8, Iss 1, p 27 (2017)
We have developed a miniature human liver (liver-sinusoid-on-a-chip) model using a dual microchannel separated by a porous membrane. Primary human hepatocytes and immortalized bovine aortic endothelial cells were co-cultured on opposite sides of a mi
Externí odkaz:
https://doaj.org/article/a2be50c429064bac888cccc44dcf36ca
Autor:
Benjamin Philip Levy, Martin Reck, James Chih-Hsin Yang, Federico Cappuzzo, Siddhartha Rawat, Jingdong Xie, Priyanka Basak, Enriqueta Felip
Publikováno v:
Journal of Clinical Oncology. 40:TPS3162-TPS3162
TPS3162 Background: First-line treatment with immunotherapy has significantly improved survival in patients with adv/met NSCLC. Pembrolizumab (pembro) as monotherapy has shown superior efficacy compared with chemotherapy in treatment-naive patients w
Autor:
Gotchev Dimitar B, Timothy M. Block, Tianlun Zhou, Xiaohe Wang, Jeffrey D. Branson, Rene Rijnbrand, Tim T. Chiu, Michael J. Sofia, Chris B. Moore, Fang Guo, Hongyan Liang, Troy Harasym, Bruce D. Dorsey, Min Gao, Siddhartha Rawat, Amy C.H. Lee, Liren Sun, Bailey Lauren Danielle, Fei Liu, Andy Cuconatti, Holly M. Micolochick Steuer, Andrew S. Kondratowicz
Publikováno v:
Antiviral Research. 149:191-201
In pursuit of novel therapeutics targeting the hepatitis B virus (HBV) infection, we evaluated a dihydroquinolizinone compound (DHQ-1) that in the nanomolar range reduced the production of virion and surface protein (HBsAg) in tissue culture. This co
Publikováno v:
Virology. 498:9-22
Chronic HBV infection is a risk factor for hepatocellular carcinoma (HCC). The HBV HBx protein stimulates HBV replication and likely influences the development of HBV-associated HCC. Whether HBx affects regulators of metabolism in normal hepatocytes
Autor:
Siddhartha Rawat, Michael J. Bouchard
Publikováno v:
Journal of Virology. 89:999-1012
Chronic infection with hepatitis B virus (HBV) is a risk factor for developing liver diseases such as hepatocellular carcinoma (HCC). HBx is a multifunctional protein encoded by the HBV genome; HBx stimulates HBV replication and is thought to play an
Publikováno v:
Micromachines, Vol 8, Iss 1, p 27 (2017)
Micromachines
Micromachines; Volume 8; Issue 1; Pages: 27
Micromachines
Micromachines; Volume 8; Issue 1; Pages: 27
We have developed a miniature human liver (liver-sinusoid-on-a-chip) model using a dual microchannel separated by a porous membrane. Primary human hepatocytes and immortalized bovine aortic endothelial cells were co-cultured on opposite sides of a mi
Autor:
Mengjun Wang, Pamela A. Norton, Jason Lamontagne, Aarti A. Ramanathan, Laura F. Steel, Anand Mehta, Lucy Betesh, Jessica C. Casciano, Siddhartha Rawat, Harmin Herrera, Mary Ann Comunale, Michael J. Bouchard
Publikováno v:
Scientific Reports
Alterations in N-linked glycosylation have long been associated with cancer but for the most part, the reasons why have remained poorly understood. Here we show that increased core fucosylation is associated with de-differentiation of primary hepatoc
Autor:
Joseph Cirillo, Siddhartha Rawat, Michael J. Bouchard, Young Bok Abraham Kang, Hongseok (Moses) Noh
Publikováno v:
Volume 9: Micro- and Nano-Systems Engineering and Packaging, Parts A and B.
This paper presents a novel liver model platform that mimics the liver sinusoid, a functional unit of the liver where most liver activities occur. A key component of the current liver model is a layered co-culture of primary rat hepatocytes (PRH) and
Autor:
Lucy Betesh, Mengjun Wang, Jessica Garner, Anand Mehta, Siddhartha Rawat, Laura F. Steel, Mary Ann Comunale, Michael J. Bouchard
Publikováno v:
Cancer Research. 75:4982-4982
Alterations in N-linked glycosylation have been associated with the development of cancer. One such modification, core fucosylation has been observed in many cancers and is actually used clinically in the diagnosis of hepatocellular carcinoma (HCC).