Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Siddhartha Bhoopathy"'
Autor:
Haruki Higashino, Corey Develin, Chie Higashino, Tyler Lim, Blair Miezeiewski, Robert Strab, Rachana Patel, Siddhartha Bhoopathy, Ismael Hidalgo
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 188:147-152
Autor:
Haruki Higashino, Corey Develin, Chie Higashino, Tyler Lim, Andrew Martin, Feng Zhou, Robert Strab, Rachana Patel, Siddhartha Bhoopathy, Ismael Hidalgo
Publikováno v:
Journal of Drug Delivery Science and Technology. 83:104439
Autor:
Vatsala Naageshwaran, Veli-Pekka Ranta, Elisa Toropainen, Marjo Tuomainen, Glenwood Gum, Enli Xie, Siddhartha Bhoopathy, Arto Urtti, Eva M. del Amo
Publikováno v:
International Journal of Pharmaceutics. 615:121515
Topical corticosteroids are used to treat inflammation of the anterior segment. Due to their low water-solubility, they are often formulated as suspensions, but ocular bioavailability of the suspensions is not known. Herein, ocular pharmacokinetics o
Autor:
Arto Urtti, Vatsala Naageshwaran, Siddhartha Bhoopathy, Glenwood Gum, Veli-Pekka Ranta, Eva M. del Amo
Publikováno v:
Journal of pharmaceutical sciences. 110(1)
Brinzolamide is a topical carbonic anhydrase inhibitor which reduces the production of aqueous humor in the ciliary body, thereby reducing intra-ocular pressure. It is formulated as an ophthalmic suspension. The pharmacokinetics of ocular suspensions
Autor:
Swati Nagar, Ken Korzekwa, Ismael J. Hidalgo, Erica A. Weiskircher, Jalia Tucker, Siddhartha Bhoopathy
Publikováno v:
Pharmaceutical Research. 31:347-359
With the goal of quantifying P-gp transport kinetics, Part 1 of these manuscripts evaluates different compartmental models and Part 2 applies these models to kinetic data.Models were developed to simulate the effect of apical efflux transporters on i
Autor:
Swati Nagar, Jalia Tucker, Erica A. Weiskircher, Siddhartha Bhoopathy, Kenneth R. Korzekwa, Ismael J. Hidalgo
Publikováno v:
Drug Metabolism and Disposition. 40:865-876
Knowledge of free drug intracellular concentration is necessary to predict the impacts of drugs on intracellular targets. The goal of this study was to develop models to predict free intracellular drug concentrations in the presence of apical efflux
Autor:
Kelly L. Robinson, Gerald R. Rhodes, Darius Babusis, Robert Strab, Leah Tong, Siddhartha Bhoopathy, Adrian S. Ray, Truc K. Phan, Ismael J. Hidalgo
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:3498-3504
Human immunodeficiency virus protease inhibitors (PIs) modestly affect the plasma pharmacokinetics of tenofovir (TFV; −15% to +37% change in exposure) following coadministration with the oral prodrug TFV disoproxil fumarate (TDF) by a previously un
Autor:
D. Scott Wright, Zong-Ping Zhang, Rand Jenkins, Songmei Gao, H. Thomas Karnes, Siddhartha Bhoopathy
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 40:679-688
A liquid chromatography method using volatile ion-pairing reagents and tandem mass spectrometry was developed to obviate observed matrix effect for ionizable polar compounds. The present study investigated the addition of volatile ion-pair reagents t
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 25(5-6)
A capillary electrophoresis (CE) method has been developed for the determination of quinidine sulfate (QS) and (3S)-3-hydroxyquinidine (3-OHQ) by direct injection of microsomal incubation mixtures. 3-OHQ is the CYP 3A4 metabolite of QS and hence usef