Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Siddhartha, Jaiswal"'
Autor:
Yash Pershad, Taralynn Mack, Hannah Poisner, Yasminka A. Jakubek, Adrienne M. Stilp, Braxton D. Mitchell, Joshua P. Lewis, Eric Boerwinkle, Ruth J. F. Loos, Nathalie Chami, Zhe Wang, Kathleen Barnes, Nathan Pankratz, Myriam Fornage, Susan Redline, Bruce M. Psaty, Joshua C. Bis, Ali Shojaie, Edwin K. Silverman, Michael H. Cho, Jeong H. Yun, Dawn DeMeo, Daniel Levy, Andrew D. Johnson, Rasika A. Mathias, Margaret A. Taub, Donna Arnett, Kari E. North, Laura M. Raffield, April P. Carson, Margaret F. Doyle, Stephen S. Rich, Jerome I. Rotter, Xiuqing Guo, Nancy J. Cox, Dan M. Roden, Nora Franceschini, Pinkal Desai, Alex P. Reiner, Paul L. Auer, Paul A. Scheet, Siddhartha Jaiswal, Joshua S. Weinstock, Alexander G. Bick
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger st
Externí odkaz:
https://doaj.org/article/1250c0a2d37c41cbad1c671a34d1b82b
Autor:
Zhi Yu, Trevor P. Fidler, Yunfeng Ruan, Caitlyn Vlasschaert, Tetsushi Nakao, Md Mesbah Uddin, Taralynn Mack, Abhishek Niroula, J. Brett Heimlich, Seyedeh M. Zekavat, Christopher J. Gibson, Gabriel K. Griffin, Yuxuan Wang, Gina M. Peloso, Nancy Heard-Costa, Daniel Levy, Ramachandran S. Vasan, François Aguet, Kristin G. Ardlie, Kent D. Taylor, Stephen S. Rich, Jerome I. Rotter, Peter Libby, Siddhartha Jaiswal, Benjamin L. Ebert, Alexander G. Bick, Alan R. Tall, Pradeep Natarajan
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVDs), putatively via inflammasome activation. We pursued an inflammatory gene modifier scan for CHIP-associated CVD risk among 42
Externí odkaz:
https://doaj.org/article/4b73ca94ea51466da314839f5b8ac232
Autor:
Art Schuermans, Tetsushi Nakao, Yunfeng Ruan, Satoshi Koyama, Zhi Yu, Md Mesbah Uddin, Sara Haidermota, Whitney Hornsby, Adam J. Lewandowski, Alexander G. Bick, Abhishek Niroula, Siddhartha Jaiswal, Benjamin L. Ebert, Pradeep Natarajan, Michael C. Honigberg
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 13 (2023)
Background High and low birth weight are independently associated with increased cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential (CHIP), the age‐related clonal expansion of hematopoietic cells with preleuke
Externí odkaz:
https://doaj.org/article/0d0b797babec43fb8c439a6fafd33620
Autor:
M d Mesbah Uddin, Ngoc Quynh H. Nguyen, Bing Yu, Jennifer A. Brody, Akhil Pampana, Tetsushi Nakao, Myriam Fornage, Jan Bressler, Nona Sotoodehnia, Joshua S. Weinstock, Michael C. Honigberg, Daniel Nachun, Romit Bhattacharya, Gabriel K. Griffin, Varuna Chander, Richard A. Gibbs, Jerome I. Rotter, Chunyu Liu, Andrea A. Baccarelli, Daniel I. Chasman, Eric A. Whitsel, Douglas P. Kiel, Joanne M. Murabito, Eric Boerwinkle, Benjamin L. Ebert, Siddhartha Jaiswal, James S. Floyd, Alexander G. Bick, Christie M. Ballantyne, Bruce M. Psaty, Pradeep Natarajan, Karen N. Conneely
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Clonal hematopoiesis, often caused by mutations in DNMT3A and TET2, is associated with blood cancer and coronary artery disease. Here, the authors conduct an epigenome-wide association study, finding that clonal hematopoiesis caused by DNMT3A vs. TET
Externí odkaz:
https://doaj.org/article/c22e81f057bd44ef857ef1b82f628c5a
Autor:
Md Mesbah Uddin, Ying Zhou, Alexander G. Bick, Bala Bharathi Burugula, Siddhartha Jaiswal, Pinkal Desai, Michael C. Honigberg, Shelly-Ann Love, Ana Barac, Kathleen M. Hayden, JoAnn E. Manson, Eric A. Whitsel, Charles Kooperberg, Pradeep Natarajan, Alexander P. Reiner, Jacob O. Kitzman
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-10 (2022)
Abstract Background Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of mutant hematopoietic stem cells, confers risk for multiple diseases of aging including hematologic cancer and cardiovascular disease. Whole-exome
Externí odkaz:
https://doaj.org/article/5670ae5d22a24c91b17e0de5cef958b8
Autor:
Kenneth Walsh, Nalini Raghavachari, Candace Kerr, Alexander G. Bick, Steven R. Cummings, Todd Druley, Cynthia E. Dunbar, Giulio Genovese, Margaret A. Goodell, Siddhartha Jaiswal, Jaroslaw Maciejewski, Pradeep Natarajan, Anastasia V. Shindyapina, Alan R. Shuldiner, Erik B. Van Den Akker, Jan Vijg
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Aging is characterized by increased mortality, functional decline, and exponential increases in the incidence of diseases such as cancer, stroke, cardiovascular disease, neurological disease, respiratory disease, etc. Though the role of aging in thes
Externí odkaz:
https://doaj.org/article/91cc6f1fb0f44f728c443e64a1e07a92
Autor:
Brunilda Balliu, Matthew Durrant, Olivia de Goede, Nathan Abell, Xin Li, Boxiang Liu, Michael J. Gloudemans, Naomi L. Cook, Kevin S. Smith, David A. Knowles, Mauro Pala, Francesco Cucca, David Schlessinger, Siddhartha Jaiswal, Chiara Sabatti, Lars Lind, Erik Ingelsson, Stephen B. Montgomery
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-16 (2019)
Abstract Background Molecular and cellular changes are intrinsic to aging and age-related diseases. Prior cross-sectional studies have investigated the combined effects of age and genetics on gene expression and alternative splicing; however, there h
Externí odkaz:
https://doaj.org/article/1842e8c1d4754a6bb67cfbd15495ae77
Autor:
Esra D. Gumuser, Art Schuermans, So Mi Jemma Cho, Zachary A. Sporn, Md Mesbah Uddin, Kaavya Paruchuri, Tetsushi Nakao, Zhi Yu, Sara Haidermota, Whitney Hornsby, Lachelle D. Weeks, Abhishek Niroula, Siddhartha Jaiswal, Peter Libby, Benjamin L. Ebert, Alexander G. Bick, Pradeep Natarajan, Michael C. Honigberg
Publikováno v:
J Am Coll Cardiol
BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP)–the age-related clonal expansion of blood stem cells with leukemia-associated mutations–is a novel cardiovascular risk factor. Whether CHIP remains prognostic in individuals with
Autor:
Lachelle D. Weeks, Abhishek Niroula, Donna Neuberg, Waihay Wong, R. Coleman Lindsley, Marlise R. Luskin, Nancy Berliner, Richard M. Stone, Daniel J. DeAngelo, Robert J. Soiffer, Md Mesbah Uddin, Gabriel Griffin, Caitlyn Vlasschaert, Christopher J. Gibson, Siddhartha Jaiswal, Alexander G. Bick, Luca Malcovati, Pradeep Natarajan, Benjamin L. Ebert
Publikováno v:
NEJM Evidence. 2
Autor:
Benjamin L. Ebert, Siddhartha Jaiswal, Robert K. Bradley, Gad Getz, Chip Stewart, Elli Papaemmanuil, Luca Malcovati, Eva Hellstrom-Lindberg, Steven A. Carr, Kasper Lage, Donna S. Neuberg, Monkol Lek, Daniel G. MacArthur, Ruth Loos, Andrew D. Johnson, Michael H. Cho, Pinkal Desai, Bruce M. Psaty, Shankara Anand, Alex Barbera, Timothy Wood, Amaro Taylor-Weiner, Andrew Dunford, Abhishek Niroula, Mendy Miller, Joshua S. Weinstock, Alexander G. Bick, Björn Nilsson, Edyta Malolepsza, Benjamin Tanenbaum, Caroline Stanclift, Monica Schenone, Waihay Wong, Akansha Tarun, Marie McConkey, Cecilia A. Castellano, Anna Gallì, Maria Creignou, Gabriele Todisco, Emma R. Hoppe, Elsa Bernard, Matthew Leventhal, Ellen M. Beauchamp
Supplementary Tables S1-S19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e51f56a5f32d341b5c2e51674ff765e
https://doi.org/10.1158/2643-3230.22543738
https://doi.org/10.1158/2643-3230.22543738