Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Siddhant Bhoir"'
Publikováno v:
Biomedicines, Vol 11, Iss 11, p 2987 (2023)
Cellular organisms possess intricate DNA damage repair and tolerance pathways to manage various DNA lesions arising from endogenous or exogenous sources. The dysregulation of these pathways is associated with cancer development and progression. Synth
Externí odkaz:
https://doaj.org/article/b0fe4599ff5f46a29fffb47220391ad0
Autor:
Siddhant Bhoir, Arrigo De Benedetti
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11100 (2023)
Androgen deprivation therapy (ADT) has been the mainstay of prostate cancer (PCa) treatment, with success in developing more effective inhibitors of androgen synthesis and antiandrogens in clinical practice. However, hormone deprivation and AR ablati
Externí odkaz:
https://doaj.org/article/781d31c0fe584ebc8f679ec15097630a
Autor:
Vibha Singh, Siddhant Bhoir, Rupesh V. Chikhale, Javeena Hussain, Donard Dwyer, Richard A. Bryce, Sivapriya Kirubakaran, Arrigo De Benedetti
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101474- (2020)
Summary: Through in vitro kinase assays and docking studies, we report the synthesis and biological evaluation of a phenothiazine analog J54 with potent TLK1 inhibitory activity for prostate cancer (PCa) therapy. Most PCa deaths result from progressi
Externí odkaz:
https://doaj.org/article/41579f9992ce48f9b8b54a59a0ca431a
Synthesis, kinetics and cellular studies of new phenothiazine analogs as potent human-TLK inhibitors
Autor:
Delna Johnson, Javeena Hussain, Siddhant Bhoir, Vaishali Chandrasekaran, Parul Sahrawat, Tanya Hans, Md Imtiaz Khalil, Arrigo De Benedetti, Vijay Thiruvenkatam, Sivapriya Kirubakaran
Publikováno v:
Organic & Biomolecular Chemistry. 21:1980-1991
A series of phenothiazine analogues were synthesized to study the structure–activity relationship and their potency as TLK1 inhibitors for cancer therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2318110e8ea8dce1e2be590028d16bd
https://doi.org/10.1039/d2ob02191a
https://doi.org/10.1039/d2ob02191a
Publikováno v:
Advanced Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65afd257cef23085012f16a99240e8b0
https://doi.org/10.1002/adbi.202300102
https://doi.org/10.1002/adbi.202300102
Autor:
Delna Johnson, Javeena Hussain, Siddhant Bhoir, Parul Sahsrawat, Tanya Hans, C Vaishali, Vijay Thiruvenkatam, Sivapriya Kirubakaran
The role of protein kinases is vital in diverse cellular functions. The alterations in the expression patterns of protein kinases often implicate human cancer initiation and progression. Human Tousled-like kinases (TLKs) are evolutionary kinases foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::477f376398f2c87ca288d4aaf23767a5
https://doi.org/10.21203/rs.3.rs-1314176/v1
https://doi.org/10.21203/rs.3.rs-1314176/v1
The µ‐Opioid Receptor in Cancer and Its Role in Perineural Invasion: A Short Review and New Evidence
Autor:
Juan P. Cata, Megan L. Uhelski, Aysegul Gorur, Siddhant Bhoir, Nisa Ilsin, Patrick M. Dougherty
Publikováno v:
Advanced Biology. 6:2200020
Cancer is a significant public health problem worldwide. While there has been a steady decrease in the cancer death rate over the last two decades, the number of survivors has increased and, thus, cancer-related sequela. Pain affects the life of pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62884ef7af696851fef7140a5bc708d
https://doi.org/10.1002/adbi.202200020
https://doi.org/10.1002/adbi.202200020
Autor:
Rupesh V. Chikhale, Siddhant Bhoir, Vibha Singh, Donard S. Dwyer, Sivapriya Kirubakaran, Richard A. Bryce, Javeena Hussain, Arrigo De Benedetti
Publikováno v:
Singh, V, Bhoir, S, Chikhale, R V, Hussain, J, Dwyer, D, Bryce, R A, Kirubakaran, S & De Benedetti, A 2020, ' Generation of Phenothiazine with Potent anti-TLK1 Activity for Prostate Cancer Therapy ', iScience, pp. 101474 . https://doi.org/10.1016/j.isci.2020.101474
iScience
iScience, Vol 23, Iss 9, Pp 101474-(2020)
iScience
iScience, Vol 23, Iss 9, Pp 101474-(2020)
Summary Through in vitro kinase assays and docking studies, we report the synthesis and biological evaluation of a phenothiazine analog J54 with potent TLK1 inhibitory activity for prostate cancer (PCa) therapy. Most PCa deaths result from progressiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3628e5aeb5ecde0a963c1e26d8d3eb2a
https://www.research.manchester.ac.uk/portal/en/publications/generation-of-phenothiazine-with-potent-antitlk1-activity-for-prostate-cancer-therapy(3d458bca-db0e-412e-8694-84e5d5c606c7).html
https://www.research.manchester.ac.uk/portal/en/publications/generation-of-phenothiazine-with-potent-antitlk1-activity-for-prostate-cancer-therapy(3d458bca-db0e-412e-8694-84e5d5c606c7).html
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
Human Tousled-like kinases (TLKs) are highly conserved serine/threonine protein kinases responsible for cell proliferation, DNA repair, and genome surveillance. Their possible involvement in cancer via efficient DNA repair mechanisms have made them c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb0f2a6bab5f3c13c3a62cebe22e966
http://link.springer.com/article/10.1038/s41598-018-22744-5
http://link.springer.com/article/10.1038/s41598-018-22744-5
Autor:
Siddhant Bhoir, Javeena Hussain, Vibha Singh, Rupesh Chikhale, Richard Bryce, Sivapriya Kirubakaran, Arrigo DeBenedetti
Publikováno v:
Cancer Research. 79:1264-1264
Introduction: The standard therapy for advanced Prostate Cancer (PCa) consists of anti-androgens which provide respite from the disease progression, yet ultimately fail and result in the incurable phase of the disease: mCRPC. Targeting PCa cells befo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50e3d5fce4db83b435c5a017c594d50f
https://doi.org/10.1158/1538-7445.am2019-1264
https://doi.org/10.1158/1538-7445.am2019-1264