Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Siddha Kasar"'
Autor:
Davide Bagnara, Catherine Tang, Jennifer R. Brown, Siddha Kasar, Stacey Fernandes, Monica Colombo, Stefano Vergani, Andrea N. Mazzarello, Fabio Ghiotto, Silvia Bruno, Fortunato Morabito, Kanti R. Rai, Jonathan E. Kolitz, Jacqueline C. Barrientos, Steven L. Allen, Franco Fais, Matthew D. Scharff, Thomas MacCarthy, Nicholas Chiorazzi
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Analyses of IGHV gene mutations in chronic lymphocytic leukemia (CLL) have had a major impact on the prognostication and treatment of this disease. A hallmark of IGHV-mutation status is that it very rarely changes clonally over time. Nevertheless, ta
Externí odkaz:
https://doaj.org/article/d46eed87a5ff475f89423d3c64d17572
Autor:
Siddha Kasar, Chingiz Underbayev, Moinuddin Hassan, Ilko Ilev, Heba Degheidy, Steven Bauer, Gerald Marti, Carol Lutz, Elizabeth Raveche, Mona Batish
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149331 (2016)
New Zealand Black (NZB) mice, a de novo model of CLL, share multiple characteristics with CLL patients, including decreased expression of miR-15a/16-1. We previously discovered a point mutation and deletion in the 3' flanking region of mir-16-1 of NZ
Externí odkaz:
https://doaj.org/article/240691af79bb467eb52b2f9e2561aaaa
Autor:
Gilad Itchaki, Svitlana Tyekucheva, Shuai Dong, Ignaty Leshchiner, Ishwarya Murali, Dimitri Livitz, Emily M. Thrash, Jasneet Kaur Khalsa, Amy J. Johnson, Gad Getz, Jennifer R. Brown, Stacey M. Fernandes, Siddha Kasar, Aishath S Naeem
Publikováno v:
Blood. 138:44-56
Inhibitors of Bruton tyrosine kinase (BTK) and phosphatidylinositol 3-kinase δ (PI3Kδ) that target the B-cell receptor (BCR) signaling pathway have revolutionized the treatment of chronic lymphocytic leukemia (CLL). Mutations associated with resist
Autor:
Shinji L. Okitsu, Timothy B. Niewold, Mark A. Jensen, Yin Wu, Melinda Przetak, Siddha Kasar, Jaromir Vlach, Evgeni Tzvetkov, Albertina Pereira, Andrew Bender
Publikováno v:
ImmunoHorizons. 4:93-107
TLR7 and TLR8 are pattern recognition receptors that reside in the endosome and are activated by ssRNA molecules. TLR7 and TLR8 are normally part of the antiviral defense response, but they have also been implicated as drivers of autoimmune diseases
Autor:
Bagnara Davide, Catherine Tang, Jennifer R. Brown, Siddha Kasar, Stacey Fernandes, Monica Colombo, Stefano Vergani, Andrea N. Mazzarello, Matthew D. Scharff, Thomas MacCarthy, Franco Fais, Nicholas Chiorazzi
Analyses of IGHV gene mutations in chronic lymphocytic leukemia (CLL) have had a major impact on the prognostication and treatment of this disease. A hallmark of IGHV-mutation status is that it very rarely changes clonally over time. Nevertheless, ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::3cc5732658a80ff73492cd7e045f2884
https://zenodo.org/record/5129066
https://zenodo.org/record/5129066
Autor:
Jennifer R. Brown, Saranya Radhakrishnan, Sunita R. Setlur, Reina Improgo, Lijian Yu, Gad Getz, Kevin Hoang, Parul Benien, Stacey M. Fernandes, Charles Lee, Josephine L. Klitgaard, Haesook T. Kim, Bethany Tesar, Siddha Kasar, Wei Du, Andrew Aw
Publikováno v:
Clinical Cancer Research. 23:735-745
Purpose: Chronic lymphocytic leukemia (CLL) with 17p deletion typically progresses quickly and is refractory to most conventional therapies. However, some del(17p) patients do not progress for years, suggesting that del(17p) is not the only driving e
Autor:
Jennifer R. Brown, Divya Chaudhary, Bethany Tesar, Haesook T. Kim, Stacey M. Fernandes, Reuma Magori-Cohen, Lijian Yu, William F. Westlin, Siddha Kasar, Kevin Hoang, Ma. Reina Improgo, Wenyan Miao, Josephine L. Klitgaard
Publikováno v:
British Journal of Haematology.
The L265P somatic mutation in the Myeloid Differentiation Primary Response 88 (MYD88) gene is a recurrent mutation in chronic lymphocytic leukaemia (CLL). This mutation has functional effects in various haematological malignancies but its role in CLL
Autor:
Josephine L. Klitgaard, Siddha Kasar, Deepti Gadi, Donald R. Polaski, Qiyuan Li, Matthew L. Freedman, Alexander J. Federation, Christopher J. Ott, Stacey M. Fernandes, Amanda Souza, James E. Bradner, Romina E. Lenci, Jennifer R. Brown, Matthew A. Lawlor, Logan Schwartz
Enhancer profiling is a powerful approach for discovering cis-regulatory elements that define the core transcriptional regulatory circuits of normal and malignant cells. Gene control through enhancer activity is often dominated by a subset of lineage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75dbad923dceb29064f184d31c23aa8
https://europepmc.org/articles/PMC6298230/
https://europepmc.org/articles/PMC6298230/
Publikováno v:
Comparative Clinical Pathology. 26:269-276
Acute lymphoblastic leukemia is a hematological malignancy of lymphoid progenitor cells associated with excessive proliferation of lymphocytes, and lymphocyte markers can be used for the diagnosis and assessment of disease. Cell surface receptors, in
Autor:
Deepti Gadi, Barbara Sherry, Stacey M. Fernandes, Yang Pan, Jennifer R. Brown, Alexander R. Vartanov, Svitlana Tyekucheva, Vanessa Rai, James A. Lederer, Alec Griffith, Pui Yan Chiu, Siddha Kasar
Publikováno v:
Blood. 134:1745-1745
Idelalisib and duvelisib are FDA approved oral inhibitors of PI3K delta and PI3K delta/gamma, respectively. Previously, we reported a decrease in regulatory T cells (Tregs) associated with autoimmune hepatotoxicity in untreated CLL patients receiving